Protein Information

Cytoscape View


UniProt AC / UniProt ID P12694 / ODBA_HUMAN
Protein Name 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor
Gene Name Name: BCKDHA
Organism Homo sapiens (Human)

PRO ID PR:P12694
DAG View
PRO Name 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (human)
Definition A 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial that is encoded in the genome of human.
Short Label hBCKDHA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12694 (BCKDHA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
R117 Methylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S295 Phosphorylation phospho.ELM 12812918
Y307 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
S337 Phosphorylation O14874 (BCKDK) phospho.ELM   PhosphoSitePlus   Signor 3947057, 17287340, 17081983, ...18220336, 12812918, 18669648, 18088087
T338 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S339 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S347 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340, 17081983
Y353 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K445 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S337 Phosphorylation HPRD 12812918, 19651622, 18669648, ...20166139, 18088087, 20068231
T338 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 20068231
S339 Phosphorylation HPRD 20166139, 17081983, 20068231, ...18707149
S342 Phosphorylation HPRD 20166139
Y345 Phosphorylation HPRD 17287340, 20068231
S347 Phosphorylation HPRD 17287340, 20230923, 19664994, ...18452278, 19651622, 20166139, 12812918, 20068231
Y353 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R117 H117 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] DOID:3070 / malignant glioma [ tcga ]
Y345 C345 Biomuta DOID:1909 / melanoma [ cosmic ]
S347 L347 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]