iPTMnet Report for P12643 (BMP2)
Protein Information
| UniProt AC / UniProt ID | P12643 / BMP2_HUMAN |
| Protein Name | Bone morphogenetic protein 2 precursor |
| Gene Name | Name: BMP2 Synonyms:BMP2A; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P12643 |
| PRO Name | bone morphogenetic protein 2 (human) |
| Definition | A bone morphogenetic protein 2 that is encoded in the genome of human. |
| Short Label | hBMP2 |
| Category | organism-gene |
DAG ViewP12643 (BMP2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N135 | N-Glycosylation | score2 | GlyGen | 24336949 | ||
| T181 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K278 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N338 | N-Glycosylation | score3 | GlyGen UniProt | 9265423 | ||
| K383 | Ubiquitination | score1 | PhosphoSitePlus |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000036543 (hGDF5/iso:1/Clv:1) | Interaction | PR:P12643 (hBMP2) | PRO | 9288098 | |
| PR:Q13873-1 (hBMPR2/iso:1) | Interaction | PR:P12643 (hBMP2) | PRO | 7791754 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| N135 | K135 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T181 | S181 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K383 | N383 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] |
