Protein Information

Cytoscape View


UniProt AC / UniProt ID P12277 / KCRB_HUMAN
Protein Name Creatine kinase B-type
Gene Name Name: CKB
Synonyms:CKBB;
Organism Homo sapiens (Human)

PRO ID PR:P12277
DAG View
PRO Name creatine kinase B-type (human)
Definition A creatine kinase B-type that is encoded in the genome of human.
Short Label hCKB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12277 (CKB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 20068231, ...19651622
S6 Phosphorylation PhosphoSitePlus   RLIMS-P 27318991
K11 Ubiquitination PhosphoSitePlus
R13 Methylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
T35 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 20058876, 19651622, ...18669648, 20068231
Y39 Phosphorylation PhosphoSitePlus
R43 Methylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
R96 Methylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
R138 Methylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
R172 Methylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S199 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
R215 Methylation PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
C254 S-Nitrosylation dbSNO 19483679, 25040305
T255 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K267 Acetylation PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K307 Sumoylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
K313 Acetylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
R320 Methylation PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R13 H13 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T35 N35 Biomuta DOID:3571 / liver cancer [ icgc ]
R43 H43 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y82 * Biomuta DOID:3571 / liver cancer [ icgc ]
T133 M133 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K223 N223 Biomuta DOID:363 / uterine cancer [ tcga ]
K265 R265 Biomuta DOID:10534 / stomach cancer [ cosmic ]