iPTMnet Report for P12268 (IMPDH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12268 / IMDH2_HUMAN
Protein Name Inosine-5'-monophosphate dehydrogenase 2
Gene Name Name: IMPDH2
Synonyms:IMPD2;
Organism Homo sapiens (Human)

PRO ID PR:P12268
DAG View
PRO Name inosine-5'-monophosphate dehydrogenase 2 (human)
Definition An inosine-5'-monophosphate dehydrogenase 2 that is encoded in the genome of human.
Short Label hIMPDH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12268 (IMPDH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T63 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 30397120, 34725712, 29351928, 34019948, 35083852, 32870666, 32119511, 20305658
K109 Acetylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S122 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18847512, ...19651622, 18669648, 20068231
S122 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K124 Ubiquitination PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
C140 S-Nitrosylation dbSNO 19483679, 26338901, 22178444
S159 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S160 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 19664994, ...19691289, 17322306, 20068231
C173 S-Nitrosylation dbSNO 22178444
K181 Ubiquitination PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
R203 Methylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
R231 Methylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K293 Acetylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
T345 Phosphorylation HPRD 20068231
Y348 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
Y400 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15592455
S403 Phosphorylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
R412 Methylation PhosphoSitePlus
S416 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 19007248, ...19651622, 24275569, 20068231
K422 Acetylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S425 Phosphorylation HPRD   PhosphoSitePlus 20068231
S426 Phosphorylation HPRD   PhosphoSitePlus 20068231
R429 Methylation PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
Y459 Phosphorylation PhosphoSitePlus
C468 Methylation IEDB 31844290
K474 Ubiquitination PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
Y509 Phosphorylation PhosphoSitePlus
K511 Acetylation PhosphoSitePlus   UniProt 19608861
K511 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T63 A63 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T63 I63 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K109 R109 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K124 N124 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
C140 S140 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S160 Y160 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K181 N181 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K195 N195 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R203 C203 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
R203 H203 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K205 Q205 Biomuta DOID:3571 / liver cancer [ cosmic ]
R231 W231 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S237 F237 Biomuta DOID:363 / uterine cancer [ icgc ]
R412 S412 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R412 C412 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S416 Y416 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S426 R426 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R429 K429 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S505 G505 Biomuta DOID:1324 / lung cancer [ cosmic ]
S505 T505 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]