iPTMnet Report for P12259 (F5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12259 / FA5_HUMAN
Protein Name Coagulation factor V precursor
Gene Name Name: F5
Organism Homo sapiens (Human)

PRO ID PR:P12259
DAG View
PRO Name coagulation factor V (human)
Definition A coagulation factor V that is encoded in the genome of human.
Short Label hF5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12259 (F5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S123 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
N297 N-Glycosylation GlyGen   UniProt 16263699, 16335952, 29671580, ...29391424
Y323 Phosphorylation PhosphoSitePlus
N382 N-Glycosylation GlyGen 29391424
N460 N-Glycosylation GlyGen   UniProt 16335952, 23090970
N468 N-Glycosylation GlyGen 29391424
S517 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
T640 Phosphorylation PhosphoSitePlus   UniProt 19690332
S692 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19824718, 9525959
S692 Phosphorylation P68400 (CSNK2A1) HPRD 19824718, 9525959
Y693 Phosphorylation HPRD   PhosphoSitePlus 19824718, 20058876
T706 Phosphorylation PhosphoSitePlus
S720 Phosphorylation phospho.ELM   PhosphoSitePlus 9525959, 14594814
S720 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 9525959, 14594814
T804 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T805 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
N821 N-Glycosylation GlyGen   UniProt 16335952, 29671580, 24190977
S832 O-Glycosylation GlyGen 30459171
S851 O-Glycosylation GlyGen 25813380
S859 Phosphorylation PhosphoSitePlus   UniProt 26091039
K864 Acetylation PhosphoSitePlus
K866 Acetylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus
T898 Phosphorylation PhosphoSitePlus
S900 O-Glycosylation GlyGen 30459171
S937 Phosphorylation PhosphoSitePlus
N938 N-Glycosylation GlyGen 29391424
S955 Phosphorylation HPRD   PhosphoSitePlus 20058876
N977 N-Glycosylation GlyGen   UniProt 16335952
S985 O-Glycosylation GlyGen 25813380
T986 O-Glycosylation GlyGen 30459171, 25813380
T1038 Phosphorylation PhosphoSitePlus
T1047 Phosphorylation HPRD   PhosphoSitePlus 18491316
S1053 O-Glycosylation GlyGen 30459171, 25813380
S1053 Phosphorylation HPRD   PhosphoSitePlus 18491316
Y1056 Phosphorylation HPRD   PhosphoSitePlus 18491316
T1058 Phosphorylation HPRD   PhosphoSitePlus 18491316
T1120 O-Glycosylation GlyGen 30459171
T1129 O-Glycosylation GlyGen 30459171
S1148 O-Glycosylation GlyGen 30459171
S1148 Phosphorylation HPRD   PhosphoSitePlus 20058876
S1150 O-Glycosylation GlyGen 30459171
S1150 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18088087, 20058876
T1184 O-Glycosylation GlyGen 25813380
S1187 O-Glycosylation GlyGen 25813380
S1191 O-Glycosylation GlyGen 25813380
T1194 O-Glycosylation GlyGen 30459171, 25813380
S1196 O-Glycosylation GlyGen 25813380
S1200 O-Glycosylation GlyGen 30459171
T1202 O-Glycosylation GlyGen 30459171
T1211 O-Glycosylation GlyGen 30459171
T1212 O-Glycosylation GlyGen 30459171
S1223 O-Glycosylation GlyGen 25813380
S1232 O-Glycosylation GlyGen 25813380
T1238 O-Glycosylation GlyGen 30459171
T1239 O-Glycosylation GlyGen 30459171, 25813380
S1263 O-Glycosylation GlyGen 30459171, 25813380
T1265 O-Glycosylation GlyGen 30459171, 25813380
S1268 O-Glycosylation GlyGen 30459171, 25813380
S1277 O-Glycosylation GlyGen 25813380
T1284 O-Glycosylation GlyGen 30459171
S1290 O-Glycosylation GlyGen 30459171, 25813380
T1292 O-Glycosylation GlyGen 30459171, 25813380
S1295 O-Glycosylation GlyGen 25813380
S1299 O-Glycosylation GlyGen 25813380
T1302 O-Glycosylation GlyGen 25813380
S1304 O-Glycosylation GlyGen 25813380
S1308 O-Glycosylation GlyGen 30459171, 25813380
T1310 O-Glycosylation GlyGen 30459171, 25813380
S1313 O-Glycosylation GlyGen 30459171, 25813380
S1322 O-Glycosylation GlyGen 25813380
T1329 O-Glycosylation GlyGen 30459171
T1364 O-Glycosylation GlyGen 30459171
S1398 O-Glycosylation GlyGen 25813380
T1403 O-Glycosylation GlyGen 25813380
T1410 O-Glycosylation GlyGen 30459171
T1418 O-Glycosylation GlyGen 30459171
S1516 O-Glycosylation GlyGen 29351928
N1559 N-Glycosylation GlyGen   UniProt 16335952, 29391424, 24190977
Y1623 Phosphorylation PhosphoSitePlus
S1626 Phosphorylation PhosphoSitePlus
T1627 Phosphorylation PhosphoSitePlus
T1629 Phosphorylation PhosphoSitePlus
S1676 Phosphorylation PhosphoSitePlus
T1685 Phosphorylation PhosphoSitePlus
S1690 Phosphorylation PhosphoSitePlus
N1698 N-Glycosylation GlyGen 29391424
N1703 N-Glycosylation GlyGen 24190977
Y1783 Phosphorylation PhosphoSitePlus
Y1784 Phosphorylation PhosphoSitePlus
S2011 Phosphorylation PhosphoSitePlus
T2026 Phosphorylation PhosphoSitePlus
N2064 N-Glycosylation GlyGen 29391424
Y2149 Phosphorylation PhosphoSitePlus
S2158 Phosphorylation PhosphoSitePlus
N2181 N-Glycosylation GlyGen 10471296, 12624624
S2198 Phosphorylation PhosphoSitePlus
N2209 N-Glycosylation GlyGen 29741879, 29391424
S2211 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N297 N-Glycosylation PRO 29671580
N821 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S284 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T804 S804 Biomuta DOID:1324 / lung cancer [ cosmic ]
S859 G859 Biomuta DOID:3571 / liver cancer [ cosmic ]
K864 T864 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1038 K1038 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1058 P1058 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1148 T1148 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1150 Y1150 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1191 R1191 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1211 M1211 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1212 A1212 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1223 C1223 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1223 T1223 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1232 Y1232 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
T1238 P1238 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1263 C1263 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1284 I1284 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1292 I1292 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T1292 K1292 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
S1308 I1308 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S1322 F1322 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1329 S1329 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1364 K1364 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1623 C1623 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1676 F1676 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1685 S1685 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1690 F1690 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1783 H1783 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y2149 C2149 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S2198 F2198 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]