iPTMnet Report for P12110 (COL6A2)
Protein Information
| UniProt AC / UniProt ID | P12110 / CO6A2_HUMAN |
| Protein Name | Collagen alpha-2(VI) chain precursor |
| Gene Name | Name: COL6A2 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P12110 |
| PRO Name | collagen alpha-2(VI) chain (human) |
| Definition | A collagen alpha-2(VI) chain that is encoded in the genome of human. |
| Short Label | hCOL6A2 |
| Category | organism-gene |
DAG ViewP12110 (COL6A2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| C43 | Methylation | score1 | IEDB | 31844290 | ||
| T58 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| K120 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S126 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S127 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N140 | N-Glycosylation | score2 | GlyGen UniProt | 23090970, 29741879, 19159218, ... | ||
| K197 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T207 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T218 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S223 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K393 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S399 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y597 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| K609 | Acetylation | score1 | PhosphoSitePlus | |||
| N630 | N-Glycosylation | score1 | GlyGen | 29741879 | ||
| Y665 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S666 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S683 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S685 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K688 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K692 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T701 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
| T703 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S705 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| C748 | Methylation | score1 | IEDB | 31844290 | ||
| C777 | Methylation | score1 | IEDB | 31844290 | ||
| N785 | N-Glycosylation | score2 | GlyGen UniProt | 23090970, 29741879, 19159218, ... | ||
| T787 | O-Glycosylation | score1 | GlyGen | 23271734, 28657654 | ||
| C806 | Methylation | score1 | IEDB | 31844290 | ||
| K851 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N897 | N-Glycosylation | score2 | GlyGen UniProt | 19159218 | ||
| N954 | N-Glycosylation | score2 | GlyGen UniProt | 29741879, 19159218 | ||
| K1000 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| C43 | F43 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T58 | I58 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S126 | G126 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S127 | F127 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T207 | M207 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S399 | N399 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] | |
| Y597 | D597 | Biomuta | DOID:263 / kidney cancer [ icgc ] | |
| S683 | F683 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| C777 | R777 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| N785 | S785 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ icgc, icgc ] |
