iPTMnet Report for P12081 (HARS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12081 / HARS1_HUMAN
Protein Name Histidine--tRNA ligase, cytoplasmic
Gene Name Name: HARS1
Synonyms:HARS,HRS;
Organism Homo sapiens (Human)

PRO ID PR:P12081
DAG View
PRO Name histidine--tRNA ligase, cytoplasmic (human)
Definition A histidyl-tRNA synthetase, cytoplasmic that is encoded in the genome of human.
Short Label hHARS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12081 (HARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K12 Ubiquitination PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K57 Methylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
C83 Methylation IEDB 31844290
T94 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y363 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K443 Acetylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y363 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T58 P58 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T58 I58 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T94 A94 Biomuta DOID:1324 / lung cancer [ cosmic ]
S229 G229 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K230 T230 Biomuta DOID:1324 / lung cancer [ cosmic ]
K418 R418 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]