iPTMnet Report for P12004 (PCNA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12004 / PCNA_HUMAN
Protein Name Proliferating cell nuclear antigen
Gene Name Name: PCNA
Organism Homo sapiens (Human)

PRO ID PR:P12004
DAG View
PRO Name proliferating cell nuclear antigen (human)
Definition A proliferating cell nuclear antigen that is encoded in the genome of human.
Short Label hPCNA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12004 (PCNA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
S10 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 34725712, 25367160, 34019948, 35083852, 32119511
S10 Phosphorylation PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K14 Acetylation UniProt 19419956
K14 Ubiquitination PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
R61 Methylation PhosphoSitePlus
K77 Acetylation PhosphoSitePlus   UniProt 19608861
K77 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus   UniProt 19608861
K80 Ubiquitination PhosphoSitePlus
C81 S-Nitrosylation dbSNO 19483679, 2212679, 22126794, ...22178444
K110 Ubiquitination PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
C135 Methylation IEDB 31844290
C135 S-Nitrosylation dbSNO 26338901
K138 Ubiquitination PhosphoSitePlus
R146 Methylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
C162 S-Nitrosylation dbSNO 19483679, 22178444
K164 Acetylation PhosphoSitePlus
K164 Sumoylation PhosphoSitePlus
K164 Ubiquitination PRO   PhosphoSitePlus   UniProt 17108083, 17130289
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
T185 Phosphorylation RLIMS-P 28073635
K190 Acetylation PhosphoSitePlus
R210 Methylation PhosphoSitePlus
Y211 Phosphorylation P00533 (EGFR) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23593472, 25825764, 17115032, ...28102297, 22692198
T216 Phosphorylation PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
S228 Phosphorylation RLIMS-P 28073635
D243 Methylation IEDB 32357974
K248 Acetylation PhosphoSitePlus   UniProt 19608861
K248 Methylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
Y250 Phosphorylation HPRD   PhosphoSitePlus 17081983
K254 Sumoylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048707 (hPCNA/Ubiq:1) ubK164 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P26358 (DNMT1) S127 P12004 (PCNA) decreased_association eFIP 20613874
Phosphorylation P38936 (CDKN1A) S146 P12004 (PCNA) inhibited_association eFIP 11756412
Phosphorylation P39748 (FEN1) S187 P12004 (PCNA) unknown eFIP 20729856
Phosphorylation Q13263 (TRIM28) S473 P12004 (PCNA) unknown eFIP 29955894


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037504 (hDNMT1/UnPhos:1) Interaction PR:P12004 (hPCNA) PRO 20613874
PR:000037505 (hDNMT1/Phos:1) decreased Interaction PR:P12004 (hPCNA) PRO 20613874
PR:000037506 (hDNMT1/Phos:2) decreased Interaction PR:P12004 (hPCNA) PRO 20613874


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R61 H61 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K77 N77 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S134 G134 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K138 N138 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R146 C146 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C162 Y162 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R210 K210 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y211 H211 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S228 N228 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S261 Y261 Biomuta DOID:363 / uterine cancer [ icgc ]