iPTMnet Report for P11908 (PRPS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11908 / PRPS2_HUMAN
Protein Name Ribose-phosphate pyrophosphokinase 2
Gene Name Name: PRPS2
Organism Homo sapiens (Human)

PRO ID PR:P11908
DAG View
PRO Name ribose-phosphate pyrophosphokinase 2 (human)
Definition A ribose-phosphate pyrophosphokinase 2 that is encoded in the genome of human.
Short Label hPRPS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11908 (PRPS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
C91 Methylation IEDB 31844290
S103 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
K163 Methylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus   Signor 29074724
S180 Phosphorylation Q13131 (PRKAA1) Signor 29074724
R184 Methylation PhosphoSitePlus
K194 Acetylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
R204 Methylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
T272 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
Y311 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y146 F146 Biomuta DOID:4159 / skin cancer [ cosmic ]
K163 R163 Biomuta DOID:3571 / liver cancer [ cosmic ]
R204 W204 Biomuta DOID:363 / uterine cancer [ icgc ]
R204 Q204 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R204 L204 Biomuta DOID:1324 / lung cancer [ cosmic ]
T228 A228 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S308 F308 Biomuta DOID:4159 / skin cancer [ cosmic ]