Protein Information

Cytoscape View


UniProt AC / UniProt ID P11802 / CDK4_HUMAN
Protein Name Cyclin-dependent kinase 4
Gene Name Name: CDK4
Organism Homo sapiens (Human)

PRO ID PR:P11802
DAG View
PRO Name cyclin-dependent kinase 4 (human)
Definition A cell division protein kinase 4 that is encoded in the genome of human.
Short Label hCDK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11802 (CDK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
Y17 Phosphorylation P07948 (LYN) , P07947 (YES1) , P12931 (SRC) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 9989806, 7630405, 18479465
K22 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
R101 Methylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T172 Phosphorylation P50613 (CDK7) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19237565, 16327805, 19369195, ...28566333, 19237555, 19458076, 7935441, 16782892, 20484410, 8139570, 19487459, 23737759
K211 Ubiquitination PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T172 Phosphorylation HPRD 8139570


P11802 (CDK4) as PTM Enzyme



Substrate Site Score Source PMID
P04179 (SOD2) S106 PhosphoSitePlus 25578653
P06400 (RB1) T5 HPRD 9139732
P06400 (RB1) S249 Signor 15809340
P06400 (RB1) T252 PhosphoSitePlus 9190208
P06400 (RB1) T356 HPRD   PhosphoSitePlus 9139732, 9190208, 18669648
P06400 (RB1) T373 PhosphoSitePlus 9190208
P06400 (RB1) S608 PhosphoSitePlus 9010227
P06400 (RB1) S612 PhosphoSitePlus 16936279
P06400 (RB1) S780 HPRD   PhosphoSitePlus   Signor 11306463, 11254678, 21270107, ...16936279, 23336272, 15548374, 19651622, 9003781, 16326706
P06400 (RB1) S788 HPRD   PhosphoSitePlus 19651622, 9139732, 9190208, ...19664994
P06400 (RB1) S795 HPRD   PhosphoSitePlus   Signor 23336272, 19664994, 11306463, ...16936279, 10069453, 9190208, 21478909, 15172998
P06400 (RB1) S807 PhosphoSitePlus 11306463, 15548374
P06400 (RB1) S811 PhosphoSitePlus   Signor 11306463, 15809340, 15548374
P06400 (RB1) T826 HPRD   PhosphoSitePlus   Signor 15809340, 19664994, 19651622, ...18669648, 9315635, 9139732, 8626527, 20068231
P06748 (NPM1) T199 neXtProt 19933848
P15923 (TCF3) S139 PhosphoSitePlus 11114297
P15923 (TCF3) S245 PhosphoSitePlus 11114297
P17480 (UBTF) S484 neXtProt   phospho.ELM 10202152
P28749 (RBL1) T369 HPRD   phospho.ELM   PhosphoSitePlus   Signor 12006580, 11884610, 19664994, ...19664995
P28749 (RBL1) S640 phospho.ELM   PhosphoSitePlus 12006580, 11884610
P28749-1 (RBL1) S650 HPRD   phospho.ELM   Signor 12006580
P28749-2 (RBL1) S964 HPRD   phospho.ELM   PhosphoSitePlus   Signor 12006580, 11884610
P28749 (RBL1) S975 phospho.ELM   PhosphoSitePlus 12006580, 11884610, 10069453
P38398 (BRCA1) S632 neXtProt   PhosphoSitePlus   Signor 17334399
P43694 (GATA4) S105 PhosphoSitePlus 21447557
P84022 (SMAD3) T8 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19413330, 15241418, 19114991, ...20736297, 15520018, 20068231
P84022 (SMAD3) T179 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15241418, 20736297, 19114991
P84022 (SMAD3) S204 HPRD   neXtProt   PhosphoSitePlus 15241418, 20736297
P84022 (SMAD3) S208 HPRD   neXtProt   PhosphoSitePlus 15241418, 20736297
P84022 (SMAD3) S213 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15241418, 20736297, 19114991
Q06830 (PRDX1) T90 Signor 11986303
Q08050 (FOXM1) S4 PhosphoSitePlus   Signor 22094256
Q08050 (FOXM1) S35 PhosphoSitePlus 22094256
Q08050 (FOXM1) S451 PhosphoSitePlus 22094256
Q08050 (FOXM1) S489 PhosphoSitePlus 22094256
Q08050 (FOXM1) S508 PhosphoSitePlus 22094256
Q08050 (FOXM1) T510 PhosphoSitePlus 22094256
Q08050 (FOXM1) S522 PhosphoSitePlus 22094256
Q08050 (FOXM1) T600 PhosphoSitePlus 22094256
Q08050 (FOXM1) T611 PhosphoSitePlus   Signor 22094256
Q08050 (FOXM1) T620 PhosphoSitePlus   Signor 22094256
Q08050 (FOXM1) T627 PhosphoSitePlus   Signor 22094256
Q08050 (FOXM1) S704 PhosphoSitePlus 22094256
Q08999 (RBL2) T401 phospho.ELM   PhosphoSitePlus 11157749
Q08999 (RBL2) S672 phospho.ELM   PhosphoSitePlus 11157749
Q08999 (RBL2) S1035 phospho.ELM   PhosphoSitePlus 11157749
Q12778 (FOXO1) S249 PhosphoSitePlus 23469153
Q13761 (RUNX3) S356 neXtProt   PhosphoSitePlus   Signor 19351720
Q14814 (MEF2D) S98 PhosphoSitePlus 25733682
Q14814 (MEF2D) S110 PhosphoSitePlus 25733682
Q8IZL8 (PELP1) S477 PhosphoSitePlus   Signor 20807815
Q8IZL8 (PELP1) S991 Signor 20807815
Q92879 (CELF1) S302 neXtProt   PhosphoSitePlus 16931514, 18570922
Q96KS0 (EGLN2) S130 PhosphoSitePlus 26644182
Q9BQA1 (WDR77) T5 PhosphoSitePlus 20951943
Q9BQA1 (WDR77) S264 PhosphoSitePlus 20951943
Q9BQA1 (WDR77) S306 PhosphoSitePlus 20951943
Q9NS23-2 (RASSF1) S203 PhosphoSitePlus 18071316
Q9NS23 (RASSF1) S207 Signor 18071316


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046675 (hCDK4/InitMet-/Phos:2) pT172 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42771 (CDKN2A) S152 P11802 (CDK4) unknown eFIP 28120917


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1909 / melanoma [ cosmic ]
K22 M22 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K22 Q22 Biomuta DOID:4159 / skin cancer [ icgc ] DOID:1909 / melanoma [ tcga ]
K35 R35 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R101 M101 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K155 Q155 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T277 N277 Biomuta DOID:3571 / liver cancer [ icgc ]