Protein Information

Cytoscape View


UniProt AC / UniProt ID P11586 / C1TC_HUMAN
Protein Name C-1-tetrahydrofolate synthase, cytoplasmic
Gene Name Name: MTHFD1
Synonyms:MTHFC,MTHFD;
Organism Homo sapiens (Human)

PRO ID PR:P11586
DAG View
PRO Name C-1-tetrahydrofolate synthase, cytoplasmic (human)
Definition A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of human.
Short Label hMTHFD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11586 (MTHFD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
K10 Acetylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
T25 Phosphorylation HPRD   PhosphoSitePlus 20068231
K28 Ubiquitination PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
R37 Methylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
C195 S-Nitrosylation dbSNO 26338901
K198 Ubiquitination PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus   UniProt 24275569
R324 Methylation PhosphoSitePlus
C326 S-Nitrosylation dbSNO 26338901
K333 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
K364 Acetylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus   UniProt 24275569
T471 Phosphorylation HPRD 20068231
K473 Acetylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
R488 Methylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus   UniProt 24275569
R495 Methylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
R539 Methylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
T545 Phosphorylation PhosphoSitePlus
K553 Acetylation PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
K721 Acetylation PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
K739 Acetylation PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
T761 Phosphorylation PhosphoSitePlus
T763 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
K784 Ubiquitination PhosphoSitePlus
K793 Acetylation PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
K819 Acetylation PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
Y834 Phosphorylation PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus
T882 Phosphorylation PhosphoSitePlus