iPTMnet Report for P11532 (DMD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11532 / DMD_HUMAN
Protein Name Dystrophin
Gene Name Name: DMD
Organism Homo sapiens (Human)

PRO ID PR:P11532
DAG View
PRO Name dystrophin (human)
Definition A dystrophin that is encoded in the genome of human.
Short Label hDMD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11532 (DMD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Acetylation PhosphoSitePlus
K225 Acetylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
T313 Phosphorylation PhosphoSitePlus
N340 Phosphorylation UniProt 18669648
Y344 Phosphorylation UniProt 18669648
L348 Phosphorylation UniProt 18669648
T390 Phosphorylation PhosphoSitePlus
K487 Acetylation PhosphoSitePlus
E519 Phosphorylation UniProt 24275569
K614 Ubiquitination PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus   UniProt 24275569
S629 Phosphorylation UniProt 24275569
T671 Phosphorylation HPRD 20068231
T672 Phosphorylation HPRD 20068231
T679 Phosphorylation HPRD 20068231
S881 Phosphorylation PhosphoSitePlus
S894 Phosphorylation HPRD 19413330, 18767875, 18669648, ...19007248, 20068231
T960 Phosphorylation HPRD 18669648, 17081983
S988 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
K1017 Acetylation PhosphoSitePlus
S1081 Phosphorylation HPRD 20068231
S1096 Phosphorylation HPRD 18669648
T1136 Phosphorylation PhosphoSitePlus
S1161 Phosphorylation HPRD 18669648, 19007248, 20068231
K1201 Acetylation PhosphoSitePlus
K1288 Ubiquitination PhosphoSitePlus
S1442 Phosphorylation PhosphoSitePlus
S1455 O-Glycosylation GlyGen 29485866, 30379171
S1455 Phosphorylation PhosphoSitePlus
Y1509 Phosphorylation PhosphoSitePlus
S1517 Phosphorylation PhosphoSitePlus
T1525 Phosphorylation PhosphoSitePlus
Y1552 Phosphorylation PhosphoSitePlus
T1590 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S1598 O-Glycosylation GlyGen 29485866, 30379171
K1644 Ubiquitination PhosphoSitePlus
T1647 Phosphorylation HPRD 20068231
S1658 Phosphorylation PhosphoSitePlus
K1911 Acetylation PhosphoSitePlus
S2037 Phosphorylation PhosphoSitePlus
T2060 Phosphorylation PhosphoSitePlus
S2079 Phosphorylation HPRD 20068231
S2200 Phosphorylation HPRD 20068231
S2280 Phosphorylation HPRD 18669648, 19007248, 20068231
S2306 Phosphorylation PhosphoSitePlus
Y2651 Phosphorylation PhosphoSitePlus
S2652 Phosphorylation PhosphoSitePlus
T2656 Phosphorylation PhosphoSitePlus
S2669 Phosphorylation HPRD 20068231
S2672 Phosphorylation HPRD   PhosphoSitePlus 20068231
S2728 Phosphorylation PhosphoSitePlus
K2808 Acetylation PhosphoSitePlus
T2868 Phosphorylation PhosphoSitePlus
Y2885 Phosphorylation PhosphoSitePlus
T2913 Phosphorylation PhosphoSitePlus
S2993 Phosphorylation PhosphoSitePlus
S3066 Phosphorylation PhosphoSitePlus
T3081 Phosphorylation PhosphoSitePlus
S3291 Phosphorylation HPRD   PhosphoSitePlus 20068231
K3308 Ubiquitination PhosphoSitePlus
K3312 Ubiquitination PhosphoSitePlus
K3317 Ubiquitination PhosphoSitePlus
K3351 Ubiquitination PhosphoSitePlus
Y3354 Phosphorylation PhosphoSitePlus
Y3359 Phosphorylation PhosphoSitePlus
T3361 Phosphorylation PhosphoSitePlus
K3374 Ubiquitination PhosphoSitePlus
Y3394 Phosphorylation HPRD 20068231
T3399 Phosphorylation phospho.ELM 18669648
T3408 Phosphorylation phospho.ELM 18669648
S3420 Phosphorylation HPRD 20068231
S3424 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3425 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S3429 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T3433 Phosphorylation phospho.ELM 18669648
S3435 Phosphorylation phospho.ELM 18669648
S3483 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S3490 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 24275569, 20068231
S3500 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18767875, 19007248, ...18669648, 24275569, 20068231
Y3524 Phosphorylation PhosphoSitePlus
S3537 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S3541 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T3548 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S3549 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3552 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K3563 Ubiquitination PhosphoSitePlus
T3610 Phosphorylation PhosphoSitePlus
S3612 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S3613 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19007248, 20068231
S3615 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18767875, 19007248, ...18669648, 20068231
T3616 Phosphorylation HPRD   PhosphoSitePlus 19413330
S3617 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19007248, 20068231
S3621 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19007248, 20068231
S3623 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18767875, ...19007248, 18669648, 24275569, 20068231
S3624 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
T3652 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S3666 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T3675 Phosphorylation PhosphoSitePlus
T3684 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S223 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S223 Phosphorylation HPRD 20068231
T331 Phosphorylation HPRD   PhosphoSitePlus 18669648
T340 Phosphorylation HPRD   PhosphoSitePlus 18669648
S343 Phosphorylation HPRD   PhosphoSitePlus 18669648
S344 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S348 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
T352 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17081983
S354 Phosphorylation HPRD   PhosphoSitePlus 18669648
S402 Phosphorylation HPRD 18669648
S456 Phosphorylation HPRD 20068231
S460 Phosphorylation HPRD 20068231
T467 Phosphorylation HPRD 18669648
T529 Phosphorylation PhosphoSitePlus
S531 Phosphorylation HPRD 20068231
S532 Phosphorylation HPRD 18669648, 20068231
S534 Phosphorylation HPRD 18669648, 20068231
T535 Phosphorylation HPRD 19413330
S536 Phosphorylation HPRD 18669648, 20068231
S540 Phosphorylation HPRD 18669648, 19007248, 20068231
S542 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18767875, 19007248, ...18669648, 20068231
S543 Phosphorylation HPRD 20068231
T571 Phosphorylation HPRD 18669648
S585 Phosphorylation HPRD 18669648
S596 Phosphorylation PhosphoSitePlus
T616 Phosphorylation HPRD   PhosphoSitePlus 20068231
Site PTM Type PTM Enzyme Score Source PMID
S223 Phosphorylation HPRD 20068231
Y326 Phosphorylation HPRD 20068231
S352 Phosphorylation HPRD 20068231
S357 Phosphorylation HPRD 17081983, 20068231
S361 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 18669648
S469 Phosphorylation HPRD 20068231
S473 Phosphorylation HPRD 20068231
T480 Phosphorylation HPRD 18669648
S544 Phosphorylation HPRD 20068231
S545 Phosphorylation HPRD 18669648, 20068231
S547 Phosphorylation HPRD 18669648, 20068231
T548 Phosphorylation HPRD 19413330
S549 Phosphorylation HPRD 18669648, 20068231
S553 Phosphorylation HPRD 18669648, 19007248, 20068231
S555 Phosphorylation HPRD 19413330, 18767875, 18669648, ...19007248, 20068231
S556 Phosphorylation HPRD 20068231
T584 Phosphorylation HPRD 18669648
S598 Phosphorylation HPRD 18669648
T629 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S223 Phosphorylation HPRD 20068231
Y326 Phosphorylation HPRD 20068231
S352 Phosphorylation HPRD 20068231
S357 Phosphorylation HPRD 17081983, 20068231
S361 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 18669648
S469 Phosphorylation HPRD 20068231
S473 Phosphorylation HPRD 20068231
T480 Phosphorylation HPRD 18669648
S544 Phosphorylation HPRD 20068231
S545 Phosphorylation HPRD 18669648, 20068231
S547 Phosphorylation HPRD 18669648, 20068231
T548 Phosphorylation HPRD 19413330
S549 Phosphorylation HPRD 18669648, 20068231
S553 Phosphorylation HPRD 18669648, 19007248, 20068231
S555 Phosphorylation HPRD 19413330, 18767875, 18669648, ...19007248, 20068231
S556 Phosphorylation HPRD 20068231
T584 Phosphorylation HPRD 18669648
S598 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S223 Phosphorylation HPRD 20068231
T331 Phosphorylation HPRD 18669648
T340 Phosphorylation HPRD 18669648
S343 Phosphorylation HPRD 18669648
S344 Phosphorylation HPRD 18669648, 20068231
S348 Phosphorylation HPRD 18669648, 20068231
T352 Phosphorylation HPRD 18669648, 17081983
S354 Phosphorylation HPRD 18669648
S402 Phosphorylation HPRD 18669648
S456 Phosphorylation HPRD 20068231
S460 Phosphorylation HPRD 20068231
T467 Phosphorylation HPRD 18669648
S531 Phosphorylation HPRD 20068231
S532 Phosphorylation HPRD 18669648, 20068231
S534 Phosphorylation HPRD 18669648, 20068231
T535 Phosphorylation HPRD 19413330
S536 Phosphorylation HPRD 18669648, 20068231
S540 Phosphorylation HPRD 18669648, 19007248, 20068231
S542 Phosphorylation HPRD 19413330, 18767875, 18669648, ...19007248, 20068231
S543 Phosphorylation HPRD 20068231
T571 Phosphorylation HPRD 18669648
S585 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S223 Y223 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S223 T223 Biomuta DOID:3571 / liver cancer [ cosmic ]
T331 S331 Biomuta DOID:1612 / breast cancer [ cosmic ]
T340 K340 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T352 N352 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S402 F402 Biomuta DOID:4159 / skin cancer [ cosmic ]
S415 F415 Biomuta DOID:4159 / skin cancer [ cosmic ]
T467 I467 Biomuta DOID:3571 / liver cancer [ cosmic ]
T480 I480 Biomuta DOID:3571 / liver cancer [ cosmic ]
T529 M529 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S534 F534 Biomuta DOID:3571 / liver cancer [ cosmic ]
S536 Y536 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S542 N542 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S543 G543 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S547 F547 Biomuta DOID:3571 / liver cancer [ cosmic ]
S549 Y549 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S555 N555 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S556 G556 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T571 I571 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T584 I584 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S585 F585 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S585 C585 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S598 C598 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S598 F598 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T616 A616 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T629 A629 Biomuta DOID:3571 / liver cancer [ cosmic, cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, cosmic, icgc, cosmic, icgc, cosmic, icgc ]