iPTMnet Report for P11509 (CYP2A6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11509 / CP2A6_HUMAN
Protein Name Cytochrome P450 2A6
Gene Name Name: CYP2A6
Synonyms:CYP2A3;
Organism Homo sapiens (Human)

PRO ID PR:P11509
DAG View
PRO Name cytochrome P450 2A6 (human)
Definition A cytochrome P450 2A that is a translation product of the CYP2A6 gene in human.
Short Label hCYP2A6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11509 (CYP2A6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S131 Phosphorylation HPRD   PhosphoSitePlus 20166139
R148 Methylation PhosphoSitePlus
R161 Methylation PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R148 C148 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R148 H148 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R161 W161 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T295 M295 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]