Protein Information

Cytoscape View


UniProt AC / UniProt ID P11498 / PYC_HUMAN
Protein Name Pyruvate carboxylase, mitochondrial precursor
Gene Name Name: PC
Organism Homo sapiens (Human)

PRO ID PR:P11498
DAG View
PRO Name pyruvate carboxylase, mitochondrial (human)
Definition A pyruvate carboxylase, mitochondrial that is encoded in the genome of human.
Short Label hPC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11498 (PC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
T513 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
T824 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
Y837 Phosphorylation PhosphoSitePlus
K892 Ubiquitination PhosphoSitePlus
Y894 Phosphorylation PhosphoSitePlus
S927 Phosphorylation PhosphoSitePlus
K969 Ubiquitination PhosphoSitePlus
K992 Acetylation PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
T1003 Phosphorylation PhosphoSitePlus
S1009 Phosphorylation PhosphoSitePlus
K1090 Acetylation PhosphoSitePlus   UniProt 19608861
T1156 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T289 Phosphorylation HPRD 20068231
S293 Phosphorylation HPRD 20068231
Y304 Phosphorylation HPRD 20068231
T309 Phosphorylation HPRD 20068231
Y894 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S26 F26 Biomuta DOID:1324 / lung cancer [ icgc ]
T72 M72 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y118 C118 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S142 R142 Biomuta DOID:1324 / lung cancer [ tcga ]
Y217 H217 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T513 I513 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K892 R892 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S927 N927 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T1003 M1003 Biomuta DOID:10534 / stomach cancer [ tcga ]
S1009 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ tcga ]
S1009 L1009 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K1090 N1090 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]