iPTMnet Report for P11474 (ESRRA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11474 / ERR1_HUMAN
Protein Name Steroid hormone receptor ERR1
Gene Name Name: ESRRA
Synonyms:ERR1,ESRL1,NR3B1;
Organism Homo sapiens (Human)

PRO ID PR:P11474
DAG View
PRO Name steroid hormone receptor ERR1 (human)
Definition A steroid hormone receptor ERR1 that is encoded in the genome of human.
Short Label hESRRA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11474 (ESRRA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K14 Sumoylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus   UniProt 18669648, 17676930, 18063693
S22 Phosphorylation PhosphoSitePlus   UniProt 18669648, 17676930, 18063693
S26 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K129 Acetylation PhosphoSitePlus   UniProt 20484414
K138 Acetylation PhosphoSitePlus   UniProt 20484414
K146 Ubiquitination PhosphoSitePlus
K160 Acetylation PhosphoSitePlus   UniProt 20484414
K162 Acetylation PhosphoSitePlus   UniProt 20484414
K189 Sumoylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
K403 Sumoylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 19413330, 18669648, 20068231
S22 Phosphorylation HPRD 19413330, 18669648, 15302935, ...20068231
S26 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
S27 Phosphorylation HPRD 18669648, 15302935, 18452278
T29 Phosphorylation HPRD 18669648, 18452278
T31 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 N19 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S26 Y26 Biomuta DOID:1612 / breast cancer [ cosmic ]
T31 I31 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y362 C362 Biomuta DOID:1324 / lung cancer [ cosmic ]