Protein Information

Cytoscape View


UniProt AC / UniProt ID P11413 / G6PD_HUMAN
Protein Name Glucose-6-phosphate 1-dehydrogenase
Gene Name Name: G6PD
Organism Homo sapiens (Human)

PRO ID PR:P11413
DAG View
PRO Name glucose-6-phosphate 1-dehydrogenase (human)
Definition A glucose-6-phosphate 1-dehydrogenase that is encoded in the genome of human.
Short Label hG6PD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11413 (G6PD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 7857286, 22814378, ...22223895
S8 Phosphorylation PhosphoSitePlus   UniProt 23186163
R9 Methylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus   UniProt 23186163
T76 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K89 Acetylation PhosphoSitePlus   UniProt 19608861
K89 Ubiquitination PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus   UniProt 19608861
K171 Ubiquitination PhosphoSitePlus
S180 Phosphorylation Q05655 (PRKCD) Signor 20649491
R182 Methylation PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
T236 Phosphorylation Q05655 (PRKCD) Signor 20649491
Y249 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus   RLIMS-P 29138396
K320 Ubiquitination PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
K386 Acetylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
Y401 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 18083107
T402 Phosphorylation PhosphoSitePlus
K403 Acetylation PhosphoSitePlus   UniProt 24769394, 19608861
K403 Ubiquitination PhosphoSitePlus
T406 Phosphorylation RLIMS-P 29138396
K408 Acetylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
Y424 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation P12931 (SRC) PhosphoSitePlus 19359662
K432 Acetylation PhosphoSitePlus   UniProt 19608861
K432 Ubiquitination PhosphoSitePlus
Y437 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
T466 Phosphorylation RLIMS-P 29138396
T490 Phosphorylation PhosphoSitePlus
K497 Acetylation PhosphoSitePlus   UniProt 19608861
K497 Ubiquitination PhosphoSitePlus
Y503 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 23186163
T506 Phosphorylation PhosphoSitePlus
Y507 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus 18083107, 15951569, 19359662
K508 Acetylation PhosphoSitePlus
K514 Acetylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation HPRD 20068231
S123 Phosphorylation HPRD 20068231
Y401 Phosphorylation HPRD 15592455, 20068231
Y503 Phosphorylation HPRD 18083107
Y507 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S26 Phosphorylation HPRD   PhosphoSitePlus 18669648
T40 Phosphorylation HPRD 20068231
Y142 Phosphorylation PhosphoSitePlus
S153 Phosphorylation HPRD 20068231
S210 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 20649491
T266 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 20649491
Y431 Phosphorylation HPRD   PhosphoSitePlus 15592455, 20068231
Y454 Phosphorylation PhosphoSitePlus
Y533 Phosphorylation HPRD   PhosphoSitePlus 18083107
Y537 Phosphorylation HPRD   PhosphoSitePlus 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 C8 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R9 Q9 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K97 R97 Biomuta DOID:363 / uterine cancer [ tcga ]
S106 F106 Biomuta DOID:1909 / melanoma [ tcga ]
Y112 H112 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y139 C139 Biomuta DOID:363 / uterine cancer [ tcga ]
S180 F180 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
R182 L182 Biomuta DOID:1324 / lung cancer [ tcga ]
Y249 C249 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S418 L418 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
Y424 H424 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K432 Q432 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y437 F437 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T466 S466 Biomuta DOID:363 / uterine cancer [ cosmic ]
T490 K490 Biomuta DOID:3571 / liver cancer [ icgc ]