Protein Information

Cytoscape View


UniProt AC / UniProt ID P11388 / TOP2A_HUMAN
Protein Name DNA topoisomerase 2-alpha
Gene Name Name: TOP2A
Synonyms:TOP2;
Organism Homo sapiens (Human)

PRO ID PR:P11388
DAG View
PRO Name DNA topoisomerase 2-alpha (human)
Definition A DNA topoisomerase 2-alpha that is encoded in the genome of human.
Short Label hTOP2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11388 (TOP2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 21406692, 22814378, 20068231
S4 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 20068231
S29 Phosphorylation P05129 (PRKCG) , P05771 (PRKCB) phospho.ELM   PhosphoSitePlus   Signor 7499337, 12569090, 17081983
Y82 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K131 Sumoylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K227 Sumoylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K254 Acetylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K278 Sumoylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus   UniProt 20068231
S285 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K386 Sumoylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K397 Acetylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K440 Sumoylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
C455 S-Nitrosylation dbSNO 26338901, 24105792
S464 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K489 Sumoylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K599 Sumoylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
Y612 Phosphorylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K625 Sumoylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K632 Sumoylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K639 Methylation PhosphoSitePlus
K639 Sumoylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K662 Sumoylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
R672 Methylation PhosphoSitePlus
K676 Sumoylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
Y805 Phosphorylation PhosphoSitePlus
T825 Phosphorylation PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
Y830 Phosphorylation PhosphoSitePlus
K893 Ubiquitination PhosphoSitePlus
T898 Phosphorylation PhosphoSitePlus
K936 Methylation PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K949 Ubiquitination PhosphoSitePlus
K967 Ubiquitination PhosphoSitePlus
K971 Acetylation PhosphoSitePlus
K971 Ubiquitination PhosphoSitePlus
K976 Ubiquitination PhosphoSitePlus
K987 Ubiquitination PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
R1026 Methylation PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
S1045 Phosphorylation PhosphoSitePlus
K1047 Ubiquitination PhosphoSitePlus
K1058 Ubiquitination PhosphoSitePlus
K1062 Ubiquitination PhosphoSitePlus
K1068 Ubiquitination PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
K1075 Sumoylation PhosphoSitePlus
K1075 Ubiquitination PhosphoSitePlus
K1088 Ubiquitination PhosphoSitePlus
S1106 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...16565220, 18669648, 17287340, 19043076, 20068231
T1112 Phosphorylation PhosphoSitePlus
K1114 Ubiquitination PhosphoSitePlus
T1119 Phosphorylation PhosphoSitePlus
K1151 Ubiquitination PhosphoSitePlus
T1157 Phosphorylation PhosphoSitePlus
K1159 Ubiquitination PhosphoSitePlus
S1162 Phosphorylation PhosphoSitePlus
S1164 Phosphorylation PhosphoSitePlus
K1184 Ubiquitination PhosphoSitePlus
K1186 Ubiquitination PhosphoSitePlus
K1196 Acetylation PhosphoSitePlus
K1196 Sumoylation PhosphoSitePlus
K1196 Ubiquitination PhosphoSitePlus
K1199 Acetylation PhosphoSitePlus
K1201 Acetylation PhosphoSitePlus
K1204 Sumoylation PhosphoSitePlus
K1204 Ubiquitination PhosphoSitePlus
T1205 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1213 Phosphorylation P27361 (MAPK3) , P06493 (CDK1) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...16964243, 18220336, 18234856, 16565220, 18669648, 7635160, 27407105, 17466629, 20068231, 17081983
K1228 Sumoylation PhosphoSitePlus
K1228 Ubiquitination PhosphoSitePlus
K1233 Acetylation PhosphoSitePlus
K1234 Acetylation PhosphoSitePlus
K1237 Acetylation PhosphoSitePlus
K1240 Sumoylation PhosphoSitePlus
K1240 Ubiquitination PhosphoSitePlus
T1244 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1247 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 23186163, ...17081983, 16565220, 18669648, 17287340, 7635160, 19690332, 20068231, 17924679
K1259 Ubiquitination PhosphoSitePlus
T1272 Phosphorylation PhosphoSitePlus
T1274 Phosphorylation PhosphoSitePlus
K1276 Acetylation PhosphoSitePlus
K1276 Ubiquitination PhosphoSitePlus
K1283 Methylation PhosphoSitePlus
K1287 Acetylation PhosphoSitePlus
K1289 Acetylation PhosphoSitePlus
S1295 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16565220
S1297 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16565220
S1299 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1302 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1303 Phosphorylation PhosphoSitePlus
S1306 Phosphorylation PhosphoSitePlus
T1324 Phosphorylation PhosphoSitePlus
T1327 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 17081983, ...18669648, 20068231
S1337 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 17081983, ...18669648, 18171681, 20068231
T1343 Phosphorylation P68400 (CSNK2A1) , P53350 (PLK1) , Q9H4B4 (PLK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17081983, 18669648, ...7499337, 18062778, 9804834, 20068231
S1351 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 16565220, ...18669648, 20068231
S1354 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17081983, 16565220, ...18669648, 20068231, 7635160
T1358 Phosphorylation phospho.ELM 18669648
T1360 Phosphorylation PhosphoSitePlus
S1361 Phosphorylation P06493 (CDK1) , P28482 (MAPK1) , P27361 (MAPK3) , P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   Signor 7635160, 21254166
S1365 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 21254166
K1367 Acetylation PhosphoSitePlus
K1367 Ubiquitination PhosphoSitePlus
S1374 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 17287340, 19690332, 20068231, 16964243
S1377 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 17287340, ...16964243, 7961967, 18669648, 9761967, 23186163, 20068231, 17081983
K1385 Sumoylation PhosphoSitePlus
K1385 Ubiquitination PhosphoSitePlus
S1387 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 16565220
S1391 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1392 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1393 Phosphorylation P06493 (CDK1) , P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor   UniProt 17081983, 18220336, 16565220, ...18669648, 19690332, 7635160
T1397 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1403 Phosphorylation PhosphoSitePlus
T1406 Phosphorylation PhosphoSitePlus
K1422 Ubiquitination PhosphoSitePlus
S1426 Phosphorylation PhosphoSitePlus
T1429 Phosphorylation PhosphoSitePlus
T1430 Phosphorylation PhosphoSitePlus
K1433 Acetylation PhosphoSitePlus
K1442 Sumoylation PhosphoSitePlus
K1442 Ubiquitination PhosphoSitePlus
R1443 Methylation PhosphoSitePlus
S1449 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1452 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1454 Acetylation PhosphoSitePlus
K1454 Ubiquitination PhosphoSitePlus
K1459 Ubiquitination PhosphoSitePlus
K1461 Ubiquitination PhosphoSitePlus
K1467 Acetylation PhosphoSitePlus
S1469 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...10942766
T1470 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S1471 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S1474 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 20068231
S1476 Phosphorylation PhosphoSitePlus   UniProt 21406692
K1480 Acetylation PhosphoSitePlus
K1484 Ubiquitination PhosphoSitePlus
S1491 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1492 Sumoylation PhosphoSitePlus
K1492 Ubiquitination PhosphoSitePlus
S1495 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1504 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...19690332, 20068231
S1512 Phosphorylation RLIMS-P 23163762
Y1521 Phosphorylation PhosphoSitePlus
S1525 Phosphorylation P68400 (CSNK2A1) , P53350 (PLK1) , P53778 (MAPK12) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 21878638, 17081983, ...7961967, 19098900, 18669648, 9761967, 18171681, 27407105, 19690332, 20068231, 16964243
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 19651622, 18691976, 19007248, ...20068231, 19691289
S29 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) , P05129 (PRKCG) HPRD 18691976, 7499337, 12569090, ...19007248, 19691289
S230 Phosphorylation HPRD 20068231
T282 Phosphorylation HPRD 19691289, 20068231
S285 Phosphorylation HPRD 20068231
S707 Phosphorylation HPRD 20068231
S1106 Phosphorylation HPRD 19413330, 17287340, 18212344, ...15302935, 19007248, 18452278, 19651622, 18669648, 12569090, 16565220, 20068231, 19691289
S1115 Phosphorylation HPRD 20068231, 18452278
S1117 Phosphorylation HPRD 18452278
S1162 Phosphorylation HPRD 18452278
S1164 Phosphorylation HPRD 18452278
T1205 Phosphorylation HPRD 20068231
S1213 Phosphorylation P06493 (CDK1) HPRD 19664995, 18691976, 19691289, ...16964243, 20058876, 19007248, 18452278, 19651622, 18669648, 12569090, 16565220, 7635160, 19415658, 20068231, 20068230
T1244 Phosphorylation HPRD 18669648, 20058876, 20068231, ...18452278
S1247 Phosphorylation P06493 (CDK1) HPRD 19413330, 18691976, 17287340, ...16565220, 18767875, 19664994, 19691289, 19664995, 19651622, 18669648, 12569090, 20058876, 19007248, 18452278, 17924679, 19415658, 20068231, 7635160
S1295 Phosphorylation HPRD 19651622, 16565220, 19691289, ...18452278
S1297 Phosphorylation HPRD 16565220, 19691289, 18452278
S1299 Phosphorylation HPRD 18452278
S1302 Phosphorylation HPRD 18452278, 19691289, 19007248
S1303 Phosphorylation HPRD 19691289, 18452278
S1306 Phosphorylation HPRD 18452278
T1327 Phosphorylation HPRD 18669648, 18452278
S1332 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231, 18452278
S1337 Phosphorylation HPRD 18691976, 19691289, 18452278, ...19651622, 18669648, 20068231
T1343 Phosphorylation P68400 (CSNK2A1) HPRD 18452278, 19651622, 18669648, ...9804834, 11940573, 8939955, 20068231
S1351 Phosphorylation HPRD 19651622, 18669648, 16565220, ...20068231, 18452278
S1354 Phosphorylation P06493 (CDK1) HPRD 7635160, 19007248, 18452278, ...19651622, 18669648, 12569090, 16565220, 20068231, 19691289
T1358 Phosphorylation HPRD 18669648, 19691289
T1360 Phosphorylation HPRD 20068231
S1361 Phosphorylation P06493 (CDK1) HPRD 12569090, 7635160
S1365 Phosphorylation HPRD 20068231
S1374 Phosphorylation HPRD 17287340, 18212344, 18452278, ...18669648, 20068231, 16964243
S1377 Phosphorylation P68400 (CSNK2A1) HPRD 18691976, 19691289, 17287340, ...16964243, 18767875, 19664994, 19664995, 19007248, 19651622, 18669648, 7961967, 18452278, 20068231, 20058876
S1387 Phosphorylation HPRD 16565220, 18452278
S1391 Phosphorylation HPRD 18669648, 20068231
S1392 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S1393 Phosphorylation P06493 (CDK1) HPRD 7635160, 19007248, 18452278, ...19651622, 18669648, 12569090, 16565220, 20068231
T1397 Phosphorylation HPRD 18669648
T1403 Phosphorylation HPRD 18452278
S1449 Phosphorylation HPRD 18669648, 20068231
S1452 Phosphorylation HPRD 18669648, 20068231
S1469 Phosphorylation P68400 (CSNK2A1) HPRD 10942766, 19691289, 18452278, ...19651622, 18669648, 20068231
T1470 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S1471 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S1474 Phosphorylation HPRD 15302935, 19691289, 18452278, ...19651622, 18669648, 20068231
S1476 Phosphorylation HPRD 19651622
S1491 Phosphorylation HPRD 18669648, 20068231
S1495 Phosphorylation HPRD 18669648, 19691289, 20068231
S1504 Phosphorylation HPRD 18669648, 20068231
Y1521 Phosphorylation HPRD 20068231
S1525 Phosphorylation P68400 (CSNK2A1) HPRD 16964243, 19007248, 18452278, ...19651622, 18669648, 7961967, 16565220, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S1239 Phosphorylation PhosphoSitePlus
S1400 Phosphorylation PhosphoSitePlus
S1403 Phosphorylation phospho.ELM 18669648
S1419 Phosphorylation PhosphoSitePlus
S1495 Phosphorylation PhosphoSitePlus
T1496 Phosphorylation PhosphoSitePlus
S1497 Phosphorylation PhosphoSitePlus
S1500 Phosphorylation PhosphoSitePlus
S1502 Phosphorylation PhosphoSitePlus
S1521 Phosphorylation phospho.ELM 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 R1 Biomuta DOID:1324 / lung cancer [ tcga ]
K156 N156 Biomuta DOID:363 / uterine cancer [ tcga ]
S249 F249 Biomuta DOID:1909 / melanoma [ tcga ]
S285 F285 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y328 F328 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T825 M825 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
R1026 I1026 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1045 F1045 Biomuta DOID:1324 / lung cancer [ tcga ]
S1045 Y1045 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1117 C1117 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1117 F1117 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K1199 E1199 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
T1205 A1205 Biomuta DOID:363 / uterine cancer [ tcga ]
K1233 M1233 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K1233 N1233 Biomuta DOID:363 / uterine cancer [ tcga ]
K1289 N1289 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1324 / lung cancer [ tcga ]
S1302 I1302 Biomuta DOID:363 / uterine cancer [ tcga ]
S1391 F1391 Biomuta DOID:1324 / lung cancer [ tcga ]
S1449 F1449 Biomuta DOID:363 / uterine cancer [ tcga ]
S1452 P1452 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
K1461 N1461 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S1512 F1512 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]