iPTMnet Report for P11387 (TOP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11387 / TOP1_HUMAN
Protein Name DNA topoisomerase 1
Gene Name Name: TOP1
Organism Homo sapiens (Human)

PRO ID PR:P11387
DAG View
PRO Name DNA topoisomerase 1 (human)
Definition A type 1B DNA topoisomerase 1 that is encoded in the genome of human.
Short Label hTOP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11387 (TOP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692, 20068231
S2 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983, ...20068231
S10 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19651622, 18408216, 20068231, 8060534
S10 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 18408216, 8060534
S21 Phosphorylation HPRD   PhosphoSitePlus 18408216, 20068231
S21 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 18408216
S57 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S73 Phosphorylation HPRD   PhosphoSitePlus 20068231
S74 Phosphorylation PhosphoSitePlus
K103 Sumoylation PhosphoSitePlus
S111 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S112 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18452278, 18669648, ...18408216, 20068231
S112 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 18408216
K117 Sumoylation PRO   PhosphoSitePlus
Y125 Phosphorylation HPRD   PhosphoSitePlus 20068231
K134 Acetylation PhosphoSitePlus
K134 Sumoylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
K148 Acetylation PhosphoSitePlus
K148 Sumoylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K153 Sumoylation PhosphoSitePlus
K158 Sumoylation PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
K164 Sumoylation PhosphoSitePlus
K172 Acetylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
Y268 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 15448168
Y268 Phosphorylation A0A173G4P4 (Abl fusion) phospho.ELM 15448168
Y268 Phosphorylation P00519 (ABL1) PhosphoSitePlus   Signor 15448168
K271 Acetylation PhosphoSitePlus
K280 Acetylation PhosphoSitePlus   UniProt 19608861
K280 Ubiquitination PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S298 Phosphorylation HPRD   PhosphoSitePlus 20068231
T303 Phosphorylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K336 Sumoylation PhosphoSitePlus
K347 Acetylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K354 Sumoylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K374 Methylation PhosphoSitePlus
K391 Sumoylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S394 Phosphorylation neXtProt   PhosphoSitePlus 18408216
S394 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 18408216
K400 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
Y426 Phosphorylation HPRD   PhosphoSitePlus 20068231
S432 Phosphorylation HPRD 20068231
K436 Sumoylation PhosphoSitePlus
K443 Acetylation PhosphoSitePlus
Y444 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K466 Methylation PhosphoSitePlus
K471 Methylation PhosphoSitePlus
Y480 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus   UniProt 23555599, 23185622
S506 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 23185622, 23555599
K545 Acetylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
R567 Methylation PhosphoSitePlus
T570 Phosphorylation PhosphoSitePlus
K575 Acetylation PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
T591 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K642 Acetylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
S643 O-Glycosylation GlyGen 33214551, 34725712, 32522876, ...34019948, 32119511, 28510447, 33465208
T649 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
S667 Phosphorylation IEDB 35494241
S686 Phosphorylation PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
T706 Phosphorylation PhosphoSitePlus
K712 Acetylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
Y723 Phosphorylation PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049509 (hTOP1/InitMet-/Sumo:1) suK117 PRO