Protein Information

Cytoscape View


UniProt AC / UniProt ID P11362 / FGFR1_HUMAN
Protein Name Fibroblast growth factor receptor 1 precursor
Gene Name Name: FGFR1
Synonyms:BFGFR,CEK,FGFBR,FLG,FLT2,HBGFR;
Organism Homo sapiens (Human)

PRO ID PR:P11362
DAG View
PRO Name fibroblast growth factor receptor 1 (human)
Definition A fibroblast growth factor receptor 1 that is encoded in the genome of human.
Short Label hFGFR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11362 (FGFR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S91 Phosphorylation PhosphoSitePlus
Y154 Phosphorylation P11362 (FGFR1) phospho.ELM   PhosphoSitePlus   Signor 10652257, 8443592, 12601080
K164 Acetylation PhosphoSitePlus
K172 Acetylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
Y280 Phosphorylation P11362 (FGFR1) phospho.ELM   PhosphoSitePlus   Signor 12601080
N296 N-Glycosylation UniProt 16335952
Y307 Phosphorylation P11362 (FGFR1) phospho.ELM   PhosphoSitePlus   Signor 8443592, 12601080
T403 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
Y463 Phosphorylation P11362 (FGFR1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12601080, 9880324, 16507368, ...8622701, 19224897
K482 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
Y572 Phosphorylation PhosphoSitePlus
Y583 Phosphorylation P11362 (FGFR1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12601080, 8622701, 16507368, ...27783942, 9880324, 19224897
Y585 Phosphorylation P11362 (FGFR1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12601080, 8622701, 16507368, ...27783942, 9880324, 19224897
S588 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
Y605 Phosphorylation P11362 (FGFR1) phospho.ELM   PhosphoSitePlus   Signor 12601080
Y613 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
Y653 Phosphorylation P51813 (BMX) , P11362 (FGFR1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22247553, 12601080, 30980524, ...31013829, 19665973, 8622701, 23716717, 16507368, 18083107, 27783942, 28806774, 9880324, 29750313, 19224897
Y654 Phosphorylation P51813 (BMX) , P11362 (FGFR1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22247553, 12601080, 30980524, ...31013829, 19665973, 8622701, 23716717, 28806774, 27783942, 16507368, 9880324, 29750313, 19224897, 29720732
K655 Ubiquitination PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
Y730 Phosphorylation P11362 (FGFR1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12601080, 9880324, 16507368, ...8622701, 19224897
K748 Ubiquitination PhosphoSitePlus
Y766 Phosphorylation P11362 (FGFR1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12181353, 19665973, 8622701, ...1656221, 16507368, 22247553, 9880324
Y776 Phosphorylation PhosphoSitePlus   RLIMS-P 7537362
S777 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 31013829, 20626350, 31146385, ...23405013, 18411303
S779 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus   Signor 23564461
S789 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus   RLIMS-P 24141780
Site PTM Type PTM Enzyme Score Source PMID
Y653 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
Y562 Phosphorylation HPRD 18083107
Y586 Phosphorylation HPRD 11459840
Y610 Phosphorylation HPRD 11459840
Y675 Phosphorylation Q15464 (SHB) HPRD 12181353, 7516330, 8622701
Site PTM Type PTM Enzyme Score Source PMID
Y564 Phosphorylation HPRD 18083107
Y588 Phosphorylation HPRD 11459840
Y612 Phosphorylation HPRD 11459840
Y677 Phosphorylation Q15464 (SHB) HPRD 12181353, 7516330, 8622701
Site PTM Type PTM Enzyme Score Source PMID
Y651 Phosphorylation HPRD 18083107
Y675 Phosphorylation HPRD 11459840
Y699 Phosphorylation HPRD 11459840
Y764 Phosphorylation Q15464 (SHB) HPRD 12181353, 7516330, 8622701


P11362 (FGFR1) as PTM Enzyme



Substrate Site Score Source PMID
O60506 (SYNCRIP) Y373 phospho.ELM   Signor 12601080
P00338 (LDHA) Y10 PhosphoSitePlus   Signor 21969607
P00338 (LDHA) Y83 PhosphoSitePlus   Signor 21969607
P11362 (FGFR1) Y154 phospho.ELM   PhosphoSitePlus   Signor 10652257, 8443592, 12601080
P11362 (FGFR1) Y280 phospho.ELM   Signor 12601080
P11362 (FGFR1) Y307 phospho.ELM   Signor 8443592, 12601080
P11362 (FGFR1) Y463 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19224897, 16507368, 8622701
P11362 (FGFR1) Y583 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19224897, 16507368, 8622701
P11362 (FGFR1) Y585 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19224897, 16507368, 8622701
P11362 (FGFR1) Y605 phospho.ELM   Signor 12601080
P11362 (FGFR1) Y653 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19224897, 16507368, 8622701
P11362 (FGFR1) Y654 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19224897, 16507368, 8622701
P11362 (FGFR1) Y730 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19224897, 16507368, 8622701
P11362 (FGFR1) Y766 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19665973, 1656221, 16507368, ...8622701
P16144 (ITGB4) Y1564 PhosphoSitePlus 23677256
P51812 (RPS6KA3) Y707 phospho.ELM 12601080
P56945 (BCAR1) Y128 phospho.ELM   Signor 12601080, 11019781
P56945 (BCAR1) Y249 phospho.ELM   Signor 12601080
P56945 (BCAR1) Y306 phospho.ELM   Signor 12601080
P56945 (BCAR1) Y327 phospho.ELM   Signor 12601080
P56945 (BCAR1) Y410 phospho.ELM   Signor 12601080
Q14247 (CTTN) Y446 phospho.ELM   Signor 12601080
Q15118 (PDK1) Y136 neXtProt   PhosphoSitePlus   Signor 22195962
Q15118 (PDK1) Y243 neXtProt   PhosphoSitePlus   Signor 22195962
Q15118 (PDK1) Y244 neXtProt   PhosphoSitePlus   Signor 22195962
Q9P0J1 (PDP1) Y381 PhosphoSitePlus 24486017
Q9UBW7 (ZMYM2) Y502 PhosphoSitePlus 19658100
Q9UBW7 (ZMYM2) Y557 PhosphoSitePlus 19658100
Q9UBW7 (ZMYM2) Y595 PhosphoSitePlus 19658100
Q9UBW7 (ZMYM2) Y605 PhosphoSitePlus 19658100
Q9UBW7 (ZMYM2) Y680 PhosphoSitePlus 19658100
Q9UBW7 (ZMYM2) Y683 PhosphoSitePlus 19658100
Q9UBW7 (ZMYM2) Y729 PhosphoSitePlus 19658100
Q9Y2J4 (AMOTL2) Y107 PhosphoSitePlus 21937427


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K164 R164 Biomuta DOID:363 / uterine cancer [ tcga ]
T403 N403 Biomuta DOID:1324 / lung cancer [ cosmic ]
S447 P447 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S451 F451 Biomuta DOID:1909 / melanoma [ tcga ]
S588 T588 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S602 F602 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y654 * Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, tcga ]
K655 I655 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ]
S789 C789 Biomuta DOID:1324 / lung cancer [ tcga ]