iPTMnet Report P11362 FGFR1

Protein Information

UniProt AC / UniProt ID	P11362 / FGFR1_HUMAN
Protein Name	Fibroblast growth factor receptor 1 precursor
Gene Name	Name: FGFR1 Synonyms:BFGFR,CEK,FGFBR,FLG,FLT2,HBGFR;
Organism	Homo sapiens (Human)

PRO ID	PR:P11362 DAG View
PRO Name	fibroblast growth factor receptor 1 (human)
Definition	A fibroblast growth factor receptor 1 that is encoded in the genome of human.
Short Label	hFGFR1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P11362 (FGFR1) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S91	Phosphorylation		score1	PhosphoSitePlus
Y154	Phosphorylation	P11362 (FGFR1)	score4	phospho.ELM PhosphoSitePlus Signor	10652257, 8443592, 12601080
K164	Acetylation		score1	PhosphoSitePlus
K172	Acetylation		score1	PhosphoSitePlus
Y210	Phosphorylation		score1	PhosphoSitePlus
Y280	Phosphorylation	P11362 (FGFR1)	score3	phospho.ELM PhosphoSitePlus Signor	12601080
N296	N-Glycosylation		score1	UniProt	16335952
Y307	Phosphorylation	P11362 (FGFR1)	score4	phospho.ELM PhosphoSitePlus Signor	8443592, 12601080
T403	Phosphorylation		score1	PhosphoSitePlus
S410	Phosphorylation		score1	PhosphoSitePlus
K416	Ubiquitination		score1	PhosphoSitePlus
T428	Phosphorylation		score1	PhosphoSitePlus
S439	Phosphorylation		score1	PhosphoSitePlus
S447	Phosphorylation		score1	PhosphoSitePlus
S450	Phosphorylation		score1	PhosphoSitePlus
S451	Phosphorylation		score1	PhosphoSitePlus
S452	Phosphorylation		score1	PhosphoSitePlus
T454	Phosphorylation		score1	PhosphoSitePlus
Y463	Phosphorylation	P11362 (FGFR1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	12601080, 9880324, 16507368, ...8622701, 19224897
K482	Ubiquitination		score1	PhosphoSitePlus
K510	Ubiquitination		score1	PhosphoSitePlus
Y572	Phosphorylation		score1	PhosphoSitePlus
Y583	Phosphorylation	P11362 (FGFR1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	12601080, 8622701, 16507368, ...27783942, 9880324, 19224897
Y585	Phosphorylation	P11362 (FGFR1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	12601080, 8622701, 16507368, ...27783942, 9880324, 19224897
S588	Phosphorylation		score1	PhosphoSitePlus
S602	Phosphorylation		score1	PhosphoSitePlus
Y605	Phosphorylation	P11362 (FGFR1)	score3	phospho.ELM PhosphoSitePlus Signor	12601080
Y613	Phosphorylation		score1	PhosphoSitePlus
K638	Ubiquitination		score1	PhosphoSitePlus
Y653	Phosphorylation	P51813 (BMX) , P11362 (FGFR1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	22247553, 12601080, 30980524, ...31013829, 19665973, 8622701, 23716717, 16507368, 18083107, 27783942, 28806774, 9880324, 29750313, 19224897
Y654	Phosphorylation	P51813 (BMX) , P11362 (FGFR1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	22247553, 12601080, 30980524, ...31013829, 19665973, 8622701, 23716717, 28806774, 27783942, 16507368, 9880324, 29750313, 19224897, 29720732
K655	Ubiquitination		score1	PhosphoSitePlus
Y677	Phosphorylation		score1	PhosphoSitePlus
Y730	Phosphorylation	P11362 (FGFR1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	12601080, 9880324, 16507368, ...8622701, 19224897
K748	Ubiquitination		score1	PhosphoSitePlus
Y766	Phosphorylation	P11362 (FGFR1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	12181353, 19665973, 8622701, ...1656221, 16507368, 22247553, 9880324
Y776	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	7537362
S777	Phosphorylation	P28482 (MAPK1) , Q16539 (MAPK14) , P27361 (MAPK3)	score4	neXtProt PhosphoSitePlus RLIMS-P Signor	31013829, 20626350, 31146385, ...23405013, 18411303
S779	Phosphorylation	Q02156 (PRKCE)	score3	PhosphoSitePlus Signor	23564461
S789	Phosphorylation	P51812 (RPS6KA3)	score3	PhosphoSitePlus RLIMS-P	24141780

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y653	Phosphorylation		score0	HPRD	18083107

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y562	Phosphorylation		score0	HPRD	18083107
Y586	Phosphorylation		score1	HPRD	11459840
Y610	Phosphorylation		score1	HPRD	11459840
Y675	Phosphorylation	Q15464 (SHB)	score2	HPRD	12181353, 7516330, 8622701

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y564	Phosphorylation		score0	HPRD	18083107
Y588	Phosphorylation		score1	HPRD	11459840
Y612	Phosphorylation		score1	HPRD	11459840
Y677	Phosphorylation	Q15464 (SHB)	score2	HPRD	12181353, 7516330, 8622701

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y651	Phosphorylation		score0	HPRD	18083107
Y675	Phosphorylation		score1	HPRD	11459840
Y699	Phosphorylation		score1	HPRD	11459840
Y764	Phosphorylation	Q15464 (SHB)	score2	HPRD	12181353, 7516330, 8622701

P11362 (FGFR1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O60506 (SYNCRIP)	Y373	score3	phospho.ELM Signor	12601080
P00338 (LDHA)	Y10	score3	PhosphoSitePlus Signor	21969607
P00338 (LDHA)	Y83	score3	PhosphoSitePlus Signor	21969607
P11362 (FGFR1)	Y154	score4	phospho.ELM PhosphoSitePlus Signor	10652257, 8443592, 12601080
P11362 (FGFR1)	Y280	score3	phospho.ELM Signor	12601080
P11362 (FGFR1)	Y307	score4	phospho.ELM Signor	8443592, 12601080
P11362 (FGFR1)	Y463	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	19224897, 16507368, 8622701
P11362 (FGFR1)	Y583	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	19224897, 16507368, 8622701
P11362 (FGFR1)	Y585	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	19224897, 16507368, 8622701
P11362 (FGFR1)	Y605	score3	phospho.ELM Signor	12601080
P11362 (FGFR1)	Y653	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	19224897, 16507368, 8622701
P11362 (FGFR1)	Y654	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	19224897, 16507368, 8622701
P11362 (FGFR1)	Y730	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	19224897, 16507368, 8622701
P11362 (FGFR1)	Y766	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	19665973, 1656221, 16507368, ...8622701
P16144 (ITGB4)	Y1564	score2	PhosphoSitePlus	23677256
P51812 (RPS6KA3)	Y707	score2	phospho.ELM	12601080
P56945 (BCAR1)	Y128	score4	phospho.ELM Signor	12601080, 11019781
P56945 (BCAR1)	Y249	score3	phospho.ELM Signor	12601080
P56945 (BCAR1)	Y306	score3	phospho.ELM Signor	12601080
P56945 (BCAR1)	Y327	score3	phospho.ELM Signor	12601080
P56945 (BCAR1)	Y410	score3	phospho.ELM Signor	12601080
Q14247 (CTTN)	Y446	score3	phospho.ELM Signor	12601080
Q15118 (PDK1)	Y136	score3	neXtProt PhosphoSitePlus Signor	22195962
Q15118 (PDK1)	Y243	score3	neXtProt PhosphoSitePlus Signor	22195962
Q15118 (PDK1)	Y244	score3	neXtProt PhosphoSitePlus Signor	22195962
Q9P0J1 (PDP1)	Y381	score2	PhosphoSitePlus	24486017
Q9UBW7 (ZMYM2)	Y502	score2	PhosphoSitePlus	19658100
Q9UBW7 (ZMYM2)	Y557	score2	PhosphoSitePlus	19658100
Q9UBW7 (ZMYM2)	Y595	score2	PhosphoSitePlus	19658100
Q9UBW7 (ZMYM2)	Y605	score2	PhosphoSitePlus	19658100
Q9UBW7 (ZMYM2)	Y680	score2	PhosphoSitePlus	19658100
Q9UBW7 (ZMYM2)	Y683	score2	PhosphoSitePlus	19658100
Q9UBW7 (ZMYM2)	Y729	score2	PhosphoSitePlus	19658100
Q9Y2J4 (AMOTL2)	Y107	score2	PhosphoSitePlus	21937427

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K164	R164	Biomuta	DOID:363 / uterine cancer [ tcga ]
T403	N403	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S447	P447	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S451	F451	Biomuta	DOID:1909 / melanoma [ tcga ]
S588	T588	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
S602	F602	Biomuta	DOID:1909 / melanoma [ icgc, tcga ]
Y654	*	Biomuta	DOID:2394 / ovarian cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, tcga ]
K655	I655	Biomuta	DOID:1319 / brain cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ]
S789	C789	Biomuta	DOID:1324 / lung cancer [ tcga ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P11362 (FGFR1)

Protein Information

Interactive Sequence View

P11362 (FGFR1) as Substrate

P11362 (FGFR1) as PTM Enzyme

PTM sites affected in variants