iPTMnet Report P11309 PIM1

Protein Information

UniProt AC / UniProt ID	P11309 / PIM1_HUMAN
Protein Name	Serine/threonine-protein kinase pim-1
Gene Name	Name: PIM1
Organism	Homo sapiens (Human)

PRO ID	PR:P11309 DAG View
PRO Name	serine/threonine-protein kinase pim-1 (human)
Definition	A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human.
Short Label	hPIM1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P11309 (PIM1) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K5	Ubiquitination		score1	PhosphoSitePlus
S8	Phosphorylation		score4	PhosphoSitePlus UniProt	23186163, 15657054
T23	Phosphorylation		score3	PhosphoSitePlus UniProt	15657054
K24	Ubiquitination		score1	PhosphoSitePlus
K31	Ubiquitination		score1	PhosphoSitePlus
S46	Phosphorylation		score1	PhosphoSitePlus
K67	Ubiquitination		score1	PhosphoSitePlus
K94	Ubiquitination		score1	PhosphoSitePlus
S98	Phosphorylation		score3	PhosphoSitePlus UniProt	15657054
K169	Sumoylation		score1	PhosphoSitePlus
K169	Ubiquitination		score1	PhosphoSitePlus
K183	Ubiquitination		score1	PhosphoSitePlus
S189	Phosphorylation		score4	neXtProt PhosphoSitePlus	1825810, 16356754, 15657054
S189	Phosphorylation	P11309 (PIM1)	score3	neXtProt	1825810, 16356754, 15657054
K194	Ubiquitination		score1	PhosphoSitePlus
S261	Phosphorylation		score3	PhosphoSitePlus UniProt	15657054
S308	Phosphorylation		score2	IEDB PhosphoSitePlus	27869121

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S65	Phosphorylation		score3	IntAct PhosphoSitePlus	30017192

P11309 (PIM1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O14757 (CHEK1)	S280	score2	RLIMS-P+	23748345
O43524 (FOXO3)	T32	score3	neXtProt PhosphoSitePlus Signor	18593906
O43524 (FOXO3)	S253	score3	neXtProt PhosphoSitePlus Signor	18593906
P01106 (MYC)	S329	score2	neXtProt	18438430
P10275 (AR)	S215	score2	PhosphoSitePlus	22584579
P10275 (AR)	T851	score2	PhosphoSitePlus	22584579
P11309 (PIM1)	S189	score3	neXtProt	1825810, 16356754, 15657054
P27448-3 (MARK3)	T90	score3	PhosphoSitePlus Signor	15319445
P27448 (MARK3)	T95	score3	PhosphoSitePlus Signor	15319445
P27448 (MARK3)	S96	score3	PhosphoSitePlus Signor	15319445
P30304-1 (CDC25A)	S116	score2	HPRD	19413330, 12411508
P36888 (FLT3)	Y591	score3	RLIMS-P+ Signor	24040307
P38936 (CDKN1A)	T145	score4	HPRD neXtProt PhosphoSitePlus Signor	12431783, 17855660, 20307683
P38936 (CDKN1A)	S146	score4	PhosphoSitePlus Signor	17855660, 31575057
P46527 (CDKN1B)	T157	score3	neXtProt PhosphoSitePlus Signor	18593906
P46527 (CDKN1B)	T198	score3	neXtProt PhosphoSitePlus Signor	18593906
P61073 (CXCR4)	S339	score3	neXtProt PhosphoSitePlus	19687226
P68431 (H3C12)	S11	score1	Signor	17643117
Q00987 (MDM2)	S166	score3	neXtProt PhosphoSitePlus Signor	18467333
Q00987 (MDM2)	S186	score3	neXtProt PhosphoSitePlus Signor	18467333
Q01860 (POU5F1)	S288	score2	PhosphoSitePlus	22474382
Q01860 (POU5F1)	S289	score2	PhosphoSitePlus	22474382
Q04206 (RELA)	S276	score3	neXtProt PhosphoSitePlus Signor	19911008
Q12778 (FOXO1)	T24	score2	neXtProt	18593906
Q12778 (FOXO1)	S256	score2	neXtProt	18593906
Q12778 (FOXO1)	S319	score2	neXtProt	18593906
Q13309 (SKP2)	S64	score3	neXtProt PhosphoSitePlus Signor	20663873
Q13309 (SKP2)	S72	score3	neXtProt PhosphoSitePlus Signor	20663873
Q13309 (SKP2)	T417	score3	neXtProt PhosphoSitePlus Signor	20663873
Q13761 (RUNX3)	S149	score2	PhosphoSitePlus	18767071
Q13761 (RUNX3)	T151	score2	PhosphoSitePlus	18767071
Q13761 (RUNX3)	T153	score2	PhosphoSitePlus	18767071
Q13761 (RUNX3)	T155	score2	PhosphoSitePlus	18767071
Q8TA86 (RP9)	S212	score2	neXtProt	10931201
Q8TA86 (RP9)	S214	score2	neXtProt	10931201
Q92934 (BAD)	S75	score4	HPRD neXtProt PhosphoSitePlus Signor	19483729, 16403219, 15280015
Q92934 (BAD)	S99	score3	HPRD Signor	19664994, 18669648, 9381178, ...16403219, 9651683
Q92934 (BAD)	S118	score3	HPRD Signor	10949026, 18669648, 16403219, ...18707149, 20166139, 10837486
Q96B36 (AKT1S1)	T246	score2	neXtProt	19276681
Q99683 (MAP3K5)	S83	score3	neXtProt PhosphoSitePlus Signor	19749799
Q99801 (NKX3-1)	T89	score2	PhosphoSitePlus	23129228
Q99801 (NKX3-1)	S185	score2	PhosphoSitePlus	23129228
Q99801 (NKX3-1)	S186	score2	PhosphoSitePlus	23129228
Q99801 (NKX3-1)	S195	score2	PhosphoSitePlus	23129228
Q99801 (NKX3-1)	S196	score2	PhosphoSitePlus	23129228
Q9BZS1 (FOXP3)	S422	score2	PhosphoSitePlus	25096571
Q9UNQ0 (ABCG2)	T362	score3	PhosphoSitePlus Signor	18056989

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	Q00987 (MDM2)	S186	P11309 (PIM1)	unknown	eFIP	19166854
	Phosphorylation	Q99683 (MAP3K5)	S83	P11309 (PIM1)	unknown	eFIP	19749799

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K5	*	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S8	W8	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
T23	I23	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T23	S23	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
K24	N24	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
K31	M31	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S46	R46	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S46	N46	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
K67	E67	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
K94	N94	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S98	L98	Biomuta	DOID:4606 / bile duct cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S98	*	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
K169	N169	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
K183	N183	Biomuta	DOID:2531 / hematologic cancer [ cosmic, icgc ]
S189	L189	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K194	T194	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S308	L308	Biomuta	DOID:9253 / gastrointestinal stromal tumor [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P11309 (PIM1)

Protein Information

Interactive Sequence View

P11309 (PIM1) as Substrate

P11309 (PIM1) as PTM Enzyme

PTM-dependent PPI

PTM sites affected in variants