iPTMnet Report for P11308 (ERG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11308 / ERG_HUMAN
Protein Name Transcriptional regulator ERG
Gene Name Name: ERG
Organism Homo sapiens (Human)

PRO ID PR:P11308
DAG View
PRO Name transcriptional regulator ERG (human)
Definition A transcriptional regulator ERG that is encoded in the genome of human.
Short Label hERG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11308 (ERG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
S45 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 26344095
S48 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus   RLIMS-P 23918819
S86 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus   RLIMS-P 34314419, 28887309
T180 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus   RLIMS-P 25885538
Y252 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
Y293 Phosphorylation PhosphoSitePlus
K355 Methylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S93 Phosphorylation HPRD 15302935
Y345 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation HPRD 15302935


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T25 M25 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T25 S25 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S37 F37 Biomuta DOID:4159 / skin cancer [ cosmic ]
S45 F45 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S48 I48 Biomuta DOID:1324 / lung cancer [ cosmic ]
K89 R89 Biomuta DOID:1324 / lung cancer [ cosmic ]
K92 N92 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S215 F215 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K380 E380 Biomuta DOID:1319 / brain cancer [ cosmic ]
S406 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S406 L406 Biomuta DOID:4159 / skin cancer [ cosmic ]