iPTMnet Report for P11277 (SPTB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11277 / SPTB1_HUMAN
Protein Name Spectrin beta chain, erythrocytic
Gene Name Name: SPTB
Synonyms:SPTB1;
Organism Homo sapiens (Human)

PRO ID PR:P11277
DAG View
PRO Name spectrin beta chain, erythrocytic (human)
Definition A spectrin beta chain, erythrocytic that is encoded in the genome of human.
Short Label hSPTB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11277 (SPTB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
S36 Phosphorylation HPRD   PhosphoSitePlus 19651622
K62 Ubiquitination PhosphoSitePlus
C73 Methylation IEDB 31844290
T76 Phosphorylation PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
S96 Phosphorylation HPRD   PhosphoSitePlus 18452278
K102 Ubiquitination PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus   UniProt 23186163
K107 Ubiquitination PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
K355 Acetylation PhosphoSitePlus
K379 Acetylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K461 Acetylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
Y493 Phosphorylation PhosphoSitePlus
K497 Acetylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
K637 Acetylation PhosphoSitePlus
Y660 Phosphorylation PhosphoSitePlus
S671 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734, 28411811
S767 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734, 28411811
S979 Phosphorylation PhosphoSitePlus
S998 Phosphorylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus
S1226 Phosphorylation PhosphoSitePlus
S1242 Phosphorylation PhosphoSitePlus
K1258 Acetylation PhosphoSitePlus
K1262 Acetylation PhosphoSitePlus
S1297 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734, 28411811
Y1590 Phosphorylation PhosphoSitePlus
S1652 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734, 28411811
Y1672 Phosphorylation PhosphoSitePlus
Y1797 Phosphorylation PhosphoSitePlus
T1928 O-Glycosylation GlyGen 30379171, 18984734, 28411811
S1936 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734, 28411811
S1960 Phosphorylation PhosphoSitePlus
S2043 Phosphorylation PhosphoSitePlus   UniProt 24275569
S2060 Phosphorylation PhosphoSitePlus
T2073 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2110 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15065869
S2114 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 15065869, 27869121, 19651622
S2117 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15065869
S2123 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15065869, 20058876, ...19651622, 27869121
S2124 Phosphorylation PhosphoSitePlus
S2125 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 15065869, 23186163
S2128 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15065869
Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation HPRD 19651622
S96 Phosphorylation HPRD 18452278
S2178 Phosphorylation PhosphoSitePlus
Y2184 Phosphorylation PhosphoSitePlus
S2213 Phosphorylation PhosphoSitePlus
T2216 Phosphorylation PhosphoSitePlus
K2257 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 L36 Biomuta DOID:363 / uterine cancer [ icgc ]
T76 S76 Biomuta DOID:3571 / liver cancer [ cosmic ]
K379 T379 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S767 F767 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S979 F979 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ]
S1652 P1652 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1797 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T2073 M2073 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2114 F2114 Biomuta DOID:363 / uterine cancer [ cosmic ]
S2125 F2125 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]