Protein Information

Cytoscape View


UniProt AC / UniProt ID P11274 / BCR_HUMAN
Protein Name Breakpoint cluster region protein
Gene Name Name: BCR
Synonyms:BCR1,D22S11;
Organism Homo sapiens (Human)

PRO ID PR:P11274
DAG View
PRO Name breakpoint cluster region protein (human)
Definition A breakpoint cluster region protein that is encoded in the genome of human.
Short Label hBCR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11274 (BCR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
S18 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S122 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336
T130 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y177 Phosphorylation P06241 (FYN) , P07948 (LYN) , A9UF07 (BCR/ABL fusion) , P07332 (FES) , P08631 (HCK) , P00519 (ABL1) , A0A173G4P4 (Abl fusion) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11726515, 10887132, 10405761, ...9407116, 27630163, 9174058, 12124177, 15302586, 8955135, 18083107, 32927433, 8112292, 19369965, 12522270, 29438985, 9178913, 7529874, 8995379, 19690332, 16912036
K194 Acetylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus   UniProt 23186163
S205 Phosphorylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S221 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus   UniProt 23186163
S227 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
S235 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
C240 S-Nitrosylation dbSNO 26338901
Y246 Phosphorylation P07332 (FES) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15302586, 8955135
S267 Phosphorylation PhosphoSitePlus
Y276 Phosphorylation P07332 (FES) phospho.ELM   PhosphoSitePlus 8955135
Y279 Phosphorylation P07332 (FES) phospho.ELM   PhosphoSitePlus   Signor 8955135
S281 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation A9UF07 (BCR/ABL fusion) , P07332 (FES) phospho.ELM   PhosphoSitePlus   Signor 8622703, 8955135
S299 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
T310 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
S317 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
Y328 Phosphorylation A9UF07 (BCR/ABL fusion) phospho.ELM   PhosphoSitePlus   RLIMS-P 9467953
T329 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus   RLIMS-P 8912843, 11809685
S356 Phosphorylation PhosphoSitePlus   UniProt 23186163
T358 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation A9UF07 (BCR/ABL fusion) , A0A173G4P4 (Abl fusion) phospho.ELM   PhosphoSitePlus   RLIMS-P 9467953, 8912843, 8622703
S374 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus   UniProt 23186163
T385 Phosphorylation PhosphoSitePlus
S400 O-Glycosylation GlyGen 28657654
T410 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
Y436 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
Y455 Phosphorylation PhosphoSitePlus
S459 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 17081983, ...18669648, 24275569, 23186163, 12522270, 19690332
S461 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
S463 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12522270, 18669648, 23186163
S467 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus   UniProt 23186163
K486 Ubiquitination PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus   UniProt 23186163
K494 Ubiquitination PhosphoSitePlus
Y513 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
Y554 Phosphorylation PhosphoSitePlus   UniProt 23186163
K558 Ubiquitination PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
Y591 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
Y598 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
S626 Phosphorylation PhosphoSitePlus
T634 Phosphorylation PhosphoSitePlus
T635 Phosphorylation PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
T641 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y644 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12522270, 23186163
K645 Ubiquitination PhosphoSitePlus
T651 Phosphorylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
T693 Phosphorylation PhosphoSitePlus   UniProt 23186163
S698 Phosphorylation PhosphoSitePlus
Y751 Phosphorylation PhosphoSitePlus
Y756 Phosphorylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
Y844 Phosphorylation PhosphoSitePlus
T845 Phosphorylation PhosphoSitePlus
Y852 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus   UniProt 23186163
T898 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
Y910 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
T921 Phosphorylation PhosphoSitePlus
K1000 Ubiquitination PhosphoSitePlus
T1018 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus
S1039 Phosphorylation PhosphoSitePlus
K1047 Ubiquitination PhosphoSitePlus
T1049 Phosphorylation PhosphoSitePlus
K1061 Ubiquitination PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
Y1069 Phosphorylation PhosphoSitePlus
Y1089 Phosphorylation PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
K1197 Ubiquitination PhosphoSitePlus
S1264 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 11084041, 19690332, 15144186
Site PTM Type PTM Enzyme Score Source PMID
S122 Phosphorylation HPRD 19651622, 19664994, 20230923
Y177 Phosphorylation P07332 (FES) , P08631 (HCK) HPRD 16497976, 12522270, 8955135, ...9407116, 9178913
Y246 Phosphorylation P07332 (FES) HPRD 16497976, 8955135
Y276 Phosphorylation P07332 (FES) HPRD 8955135
Y279 Phosphorylation P07332 (FES) HPRD 8955135
Y283 Phosphorylation HPRD 8622703
T310 Phosphorylation HPRD 12522270
S315 Phosphorylation HPRD 20068231
S317 Phosphorylation HPRD 20068231
Y328 Phosphorylation HPRD 11376433, 9467953
S354 Phosphorylation HPRD 11376433
S356 Phosphorylation HPRD 19413330
Y360 Phosphorylation HPRD 11376433, 9467953, 8622703
Y436 Phosphorylation HPRD 16497976
S459 Phosphorylation HPRD 19651622, 12522270, 18669648, ...18088087
S463 Phosphorylation HPRD 12522270, 18669648
S467 Phosphorylation HPRD 17081983
Y591 Phosphorylation HPRD 12522270, 16497976
Y598 Phosphorylation HPRD 16497976
Y644 Phosphorylation HPRD 19651622, 12522270, 16497976, ...20230923
S1264 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S122 Phosphorylation HPRD 19651622, 19664994, 20230923
Y177 Phosphorylation P08631 (HCK) HPRD 16497976, 12522270, 8955135, ...9407116, 9178913
Y246 Phosphorylation P07332 (FES) HPRD 16497976, 8955135
Y276 Phosphorylation P07332 (FES) HPRD 8955135
Y279 Phosphorylation P07332 (FES) HPRD 8955135
Y283 Phosphorylation HPRD 8622703
T310 Phosphorylation HPRD 12522270
S315 Phosphorylation HPRD 20068231
S317 Phosphorylation HPRD 20068231
Y328 Phosphorylation HPRD 11376433, 9467953
S354 Phosphorylation HPRD 11376433
S356 Phosphorylation HPRD 19413330
Y360 Phosphorylation HPRD 11376433, 9467953, 8622703
Y436 Phosphorylation HPRD 16497976
S459 Phosphorylation HPRD 19651622, 12522270, 18669648, ...18088087
S463 Phosphorylation HPRD 12522270, 18669648
S467 Phosphorylation HPRD 17081983
Y591 Phosphorylation HPRD 12522270, 16497976
Y598 Phosphorylation HPRD 16497976
Y644 Phosphorylation HPRD 19651622, 12522270, 16497976, ...20230923
S1220 Phosphorylation HPRD 19664994


P11274 (BCR) as PTM Enzyme



Substrate Site Score Source PMID
P27348 (YWHAQ) S232 HPRD   PhosphoSitePlus 18691976, 19664995, 9360956, ...18669648, 16045749, 19415658, 20068231
P55196 (AFDN) T909 PhosphoSitePlus 12808105
P63104 (YWHAZ) T232 PhosphoSitePlus 16045749
Q15366 (PCBP2) S173 RLIMS-P+ 17475908
Q15366 (PCBP2) S189 RLIMS-P+ 17475908
Q15366 (PCBP2) T213 RLIMS-P+ 17475908
Q15366 (PCBP2) S272 RLIMS-P+ 17475908


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P11274 (BCR) Y177 P62993 (GRB2) unknown eFIP 10887132
Phosphorylation P11274 (BCR) Y177 P62993 (GRB2) unknown eFIP 8112292
Phosphorylation P11274 (BCR) Y177 P62993 (GRB2) unknown eFIP 11726515
Phosphorylation P11274 (BCR) Y177 P62994 (Grb2) unknown eFIP 7529874
Phosphorylation P11274 (BCR) Y177 P62993 (GRB2) unknown eFIP 9174058
Phosphorylation P11274 (BCR) Y177 P62993 (GRB2) unknown eFIP 8995379
Phosphorylation P11274 (BCR) Y177 Q13588 (GRAP) unknown eFIP 8995379
Phosphorylation P11274 (BCR) Y177 P62993 (GRB2) unknown eFIP 9178913
Phosphorylation P11274 (BCR) Y177 P62993 (GRB2) unknown eFIP 8955135


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S235 F235 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y283 C283 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
S315 C315 Biomuta DOID:1324 / lung cancer [ tcga ]
S315 P315 Biomuta DOID:1909 / melanoma [ cosmic ]
S317 F317 Biomuta DOID:1909 / melanoma [ tcga ]
S320 R320 Biomuta DOID:363 / uterine cancer [ tcga ]
S400 P400 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S429 L429 Biomuta DOID:363 / uterine cancer [ tcga ]
Y455 * Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S459 L459 Biomuta DOID:1909 / melanoma [ tcga ]
S467 I467 Biomuta DOID:3571 / liver cancer [ icgc ]
Y513 * Biomuta DOID:3070 / malignant glioma [ cosmic ]
S572 N572 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
T634 M634 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T651 M651 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S653 I653 Biomuta DOID:3571 / liver cancer [ icgc ]
T654 M654 Biomuta DOID:363 / uterine cancer [ tcga ]
Y756 C756 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S843 I843 Biomuta DOID:1324 / lung cancer [ tcga ]
T845 M845 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S919 A919 Biomuta DOID:263 / kidney cancer [ tcga ]
T1018 I1018 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T1018 A1018 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ tcga ]
K1197 N1197 Biomuta DOID:363 / uterine cancer [ tcga ]