iPTMnet Report P11274 BCR

Protein Information

UniProt AC / UniProt ID	P11274 / BCR_HUMAN
Protein Name	Breakpoint cluster region protein
Gene Name	Name: BCR Synonyms:BCR1,D22S11;
Organism	Homo sapiens (Human)

PRO ID	PR:P11274 DAG View
PRO Name	breakpoint cluster region protein (human)
Definition	A breakpoint cluster region protein that is encoded in the genome of human.
Short Label	hBCR
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P11274 (BCR) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position M1 S18 Y58 S88 S122 T130 S139 Y177 K194 S201 S202 S205 K213 K214 S215 S221 S222 S227 Y231 S235 S236 S239 C240 Y246 S267 Y276 Y279 S281 Y283 S299 S301 T302 S303 T310 S317 S320 Y328 T329 S340 S351 S354 S356 T358 T359 Y360 S374 S377 T385 S400 T410 S429 T432 Y436 Y455 S459 S461 S462 S463 S467 S468 S473 K486 S488 K494 Y513 S515 S540 K549 Y554 K558 Y561 S572 K583 S586 Y591 Y598 S626 T634 T635 K636 S638 T641 Y644 K645 T651 S653 T654 K662 S686 T693 S698 Y751 Y756 K795 S843 Y844 T845 Y852 S871 S894 T898 S906 Y910 S919 T921 K1000 T1018 S1030 S1035 S1039 K1047 T1049 K1061 K1066 Y1069 Y1089 K1102 K1197 S1264	PTM Type Select all Acetylation O-Glycosylation Phosphorylation S-Nitrosylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all GlyGen IntAct PhosphoSitePlus RLIMS-P Signor UniProt dbSNO neXtProt phospho.ELM	PMID
M1	Acetylation		score1	UniProt	22223895
S18	Phosphorylation		score1	PhosphoSitePlus
Y58	Phosphorylation		score1	PhosphoSitePlus
S88	Phosphorylation		score1	PhosphoSitePlus
S122	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 18220336
T130	Phosphorylation		score1	PhosphoSitePlus
S139	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
Y177	Phosphorylation	P06241 (FYN) , A9UF07 (BCR/ABL fusion) , P07332 (FES) , P08631 (HCK) , P00519 (ABL1) , P07948 (LYN) , A0A173G4P4 (Abl fusion)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	11726515, 10887132, 10405761, ...9407116, 27630163, 9174058, 12124177, 15302586, 8955135, 18083107, 32927433, 8112292, 29438985, 12522270, 19369965, 9178913, 7529874, 8995379, 19690332, 16912036
K194	Acetylation		score1	PhosphoSitePlus
S201	Phosphorylation		score1	PhosphoSitePlus
S202	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S205	Phosphorylation		score1	PhosphoSitePlus
K213	Acetylation		score1	PhosphoSitePlus
K214	Ubiquitination		score1	PhosphoSitePlus
S215	Phosphorylation		score2	PhosphoSitePlus UniProt	21406692, 23186163
S221	Phosphorylation		score1	PhosphoSitePlus
S222	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S227	Phosphorylation		score1	PhosphoSitePlus
Y231	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	16497976
S235	Phosphorylation		score1	PhosphoSitePlus
S236	Phosphorylation		score1	PhosphoSitePlus
S239	Phosphorylation		score1	PhosphoSitePlus
C240	S-Nitrosylation		score0	dbSNO	26338901
Y246	Phosphorylation	P07332 (FES)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	15302586, 8955135
S267	Phosphorylation		score1	PhosphoSitePlus
Y276	Phosphorylation	P07332 (FES)	score3	phospho.ELM PhosphoSitePlus	8955135
Y279	Phosphorylation	P07332 (FES)	score3	phospho.ELM PhosphoSitePlus Signor	8955135
S281	Phosphorylation		score1	PhosphoSitePlus
Y283	Phosphorylation	A9UF07 (BCR/ABL fusion) , P07332 (FES)	score4	phospho.ELM PhosphoSitePlus Signor	8622703, 8955135
S299	Phosphorylation		score1	PhosphoSitePlus
S301	Phosphorylation		score1	PhosphoSitePlus
T302	Phosphorylation		score1	PhosphoSitePlus
S303	Phosphorylation		score1	PhosphoSitePlus
T310	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	12522270
S317	Phosphorylation		score1	PhosphoSitePlus
S320	Phosphorylation		score1	PhosphoSitePlus
Y328	Phosphorylation	A9UF07 (BCR/ABL fusion)	score3	phospho.ELM PhosphoSitePlus RLIMS-P	9467953
T329	Phosphorylation		score1	PhosphoSitePlus
S340	Phosphorylation		score1	PhosphoSitePlus
S351	Phosphorylation		score1	PhosphoSitePlus
S354	Phosphorylation		score4	PhosphoSitePlus RLIMS-P	8912843, 11809685
S356	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T358	Phosphorylation		score1	PhosphoSitePlus
T359	Phosphorylation		score1	PhosphoSitePlus
Y360	Phosphorylation	A9UF07 (BCR/ABL fusion) , A0A173G4P4 (Abl fusion)	score4	phospho.ELM PhosphoSitePlus RLIMS-P	9467953, 8912843, 8622703
S374	Phosphorylation		score1	PhosphoSitePlus
S377	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T385	Phosphorylation		score1	PhosphoSitePlus
S400	O-Glycosylation		score1	GlyGen	28657654
T410	Phosphorylation		score1	PhosphoSitePlus
S429	Phosphorylation		score1	PhosphoSitePlus
T432	Phosphorylation		score1	PhosphoSitePlus
Y436	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	16497976
Y455	Phosphorylation		score1	PhosphoSitePlus
S459	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 18088087, 17081983, ...18669648, 24275569, 23186163, 12522270, 19690332
S461	Phosphorylation		score1	PhosphoSitePlus
S462	Phosphorylation		score1	PhosphoSitePlus
S463	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	12522270, 18669648, 23186163
S467	Phosphorylation		score1	PhosphoSitePlus
S468	Phosphorylation		score1	PhosphoSitePlus
S473	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K486	Ubiquitination		score1	PhosphoSitePlus
S488	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K494	Ubiquitination		score1	PhosphoSitePlus
Y513	Phosphorylation		score1	PhosphoSitePlus
S515	Phosphorylation		score1	PhosphoSitePlus
S540	Phosphorylation		score1	PhosphoSitePlus
K549	Ubiquitination		score1	PhosphoSitePlus
Y554	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K558	Ubiquitination		score1	PhosphoSitePlus
Y561	Phosphorylation		score1	PhosphoSitePlus
S572	Phosphorylation		score1	PhosphoSitePlus
K583	Ubiquitination		score1	PhosphoSitePlus
S586	Phosphorylation		score1	PhosphoSitePlus
Y591	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	12522270
Y598	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	16497976
S626	Phosphorylation		score1	PhosphoSitePlus
T634	Phosphorylation		score1	PhosphoSitePlus
T635	Phosphorylation		score1	PhosphoSitePlus
K636	Ubiquitination		score1	PhosphoSitePlus
S638	Phosphorylation		score1	PhosphoSitePlus
T641	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
Y644	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	12522270, 23186163
K645	Ubiquitination		score1	PhosphoSitePlus
T651	Phosphorylation		score1	PhosphoSitePlus
S653	Phosphorylation		score1	PhosphoSitePlus
T654	Phosphorylation		score1	PhosphoSitePlus
K662	Ubiquitination		score1	PhosphoSitePlus
S686	Phosphorylation		score1	PhosphoSitePlus
T693	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S698	Phosphorylation		score1	PhosphoSitePlus
Y751	Phosphorylation		score1	PhosphoSitePlus
Y756	Phosphorylation		score1	PhosphoSitePlus
K795	Ubiquitination		score1	PhosphoSitePlus
S843	Phosphorylation		score1	PhosphoSitePlus
Y844	Phosphorylation		score1	PhosphoSitePlus
T845	Phosphorylation		score1	PhosphoSitePlus
Y852	Phosphorylation		score1	PhosphoSitePlus
S871	Phosphorylation		score1	PhosphoSitePlus
S894	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T898	Phosphorylation		score1	PhosphoSitePlus
S906	Phosphorylation		score1	PhosphoSitePlus
Y910	Phosphorylation		score1	PhosphoSitePlus
S919	Phosphorylation		score1	PhosphoSitePlus
T921	Phosphorylation		score1	PhosphoSitePlus
K1000	Ubiquitination		score1	PhosphoSitePlus
T1018	Phosphorylation		score1	PhosphoSitePlus
S1030	Phosphorylation		score1	PhosphoSitePlus
S1035	Phosphorylation		score1	PhosphoSitePlus
S1039	Phosphorylation		score1	PhosphoSitePlus
K1047	Ubiquitination		score1	PhosphoSitePlus
T1049	Phosphorylation		score1	PhosphoSitePlus
K1061	Ubiquitination		score1	PhosphoSitePlus
K1066	Ubiquitination		score1	PhosphoSitePlus
Y1069	Phosphorylation		score1	PhosphoSitePlus
Y1089	Phosphorylation		score1	PhosphoSitePlus
K1102	Ubiquitination		score1	PhosphoSitePlus
K1197	Ubiquitination		score1	PhosphoSitePlus
S1264	Phosphorylation		score4	phospho.ELM PhosphoSitePlus UniProt	11084041, 19690332, 15144186

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S122 Y177 Y246 Y276 Y279 Y283 T310 S315 S317 Y328 S354 S356 Y360 Y436 S459 S463 S467 Y591 Y598 Y644 S1264	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD	PMID
S122	Phosphorylation		score0	HPRD	19651622, 19664994, 20230923
Y177	Phosphorylation	P07332 (FES) , P08631 (HCK)	score2	HPRD	16497976, 12522270, 8955135, ...9407116, 9178913
Y246	Phosphorylation	P07332 (FES)	score2	HPRD	16497976, 8955135
Y276	Phosphorylation	P07332 (FES)	score1	HPRD	8955135
Y279	Phosphorylation	P07332 (FES)	score1	HPRD	8955135
Y283	Phosphorylation		score1	HPRD	8622703
T310	Phosphorylation		score0	HPRD	12522270
S315	Phosphorylation		score0	HPRD	20068231
S317	Phosphorylation		score0	HPRD	20068231
Y328	Phosphorylation		score2	HPRD	11376433, 9467953
S354	Phosphorylation		score1	HPRD	11376433
S356	Phosphorylation		score0	HPRD	19413330
Y360	Phosphorylation		score2	HPRD	11376433, 9467953, 8622703
Y436	Phosphorylation		score0	HPRD	16497976
S459	Phosphorylation		score0	HPRD	19651622, 12522270, 18669648, ...18088087
S463	Phosphorylation		score0	HPRD	12522270, 18669648
S467	Phosphorylation		score0	HPRD	17081983
Y591	Phosphorylation		score0	HPRD	12522270, 16497976
Y598	Phosphorylation		score0	HPRD	16497976
Y644	Phosphorylation		score0	HPRD	19651622, 12522270, 16497976, ...20230923
S1264	Phosphorylation		score0	HPRD	19664994

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S122 Y177 Y246 Y276 Y279 Y283 T310 S315 S317 Y328 S354 S356 Y360 Y436 S459 S463 S467 Y591 Y598 Y644 S1220	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD	PMID
S122	Phosphorylation		score0	HPRD	19651622, 19664994, 20230923
Y177	Phosphorylation	P08631 (HCK)	score2	HPRD	16497976, 12522270, 8955135, ...9407116, 9178913
Y246	Phosphorylation	P07332 (FES)	score2	HPRD	16497976, 8955135
Y276	Phosphorylation	P07332 (FES)	score1	HPRD	8955135
Y279	Phosphorylation	P07332 (FES)	score1	HPRD	8955135
Y283	Phosphorylation		score1	HPRD	8622703
T310	Phosphorylation		score0	HPRD	12522270
S315	Phosphorylation		score0	HPRD	20068231
S317	Phosphorylation		score0	HPRD	20068231
Y328	Phosphorylation		score2	HPRD	11376433, 9467953
S354	Phosphorylation		score1	HPRD	11376433
S356	Phosphorylation		score0	HPRD	19413330
Y360	Phosphorylation		score2	HPRD	11376433, 9467953, 8622703
Y436	Phosphorylation		score0	HPRD	16497976
S459	Phosphorylation		score0	HPRD	19651622, 12522270, 18669648, ...18088087
S463	Phosphorylation		score0	HPRD	12522270, 18669648
S467	Phosphorylation		score0	HPRD	17081983
Y591	Phosphorylation		score0	HPRD	12522270, 16497976
Y598	Phosphorylation		score0	HPRD	16497976
Y644	Phosphorylation		score0	HPRD	19651622, 12522270, 16497976, ...20230923
S1220	Phosphorylation		score0	HPRD	19664994

P11274 (BCR) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P27348 (YWHAQ) P55196 (AFDN) P63104 (YWHAZ) Q15366 (PCBP2)	Site Select all By amino acid All Serine All Threonine By position S173 S189 T213 S232 T232 S272 T909	Score Select all 2 4	Source Select all HPRD PhosphoSitePlus RLIMS-P+	PMID
P27348 (YWHAQ)	S232	score4	HPRD PhosphoSitePlus	18691976, 19664995, 9360956, ...18669648, 16045749, 19415658, 20068231
P55196 (AFDN)	T909	score2	PhosphoSitePlus	12808105
P63104 (YWHAZ)	T232	score2	PhosphoSitePlus	16045749
Q15366 (PCBP2)	S173	score2	RLIMS-P+	17475908
Q15366 (PCBP2)	S189	score2	RLIMS-P+	17475908
Q15366 (PCBP2)	T213	score2	RLIMS-P+	17475908
Q15366 (PCBP2)	S272	score2	RLIMS-P+	17475908

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S235 S236 S267 Y276 Y283 S315 S317 S320 S400 S429 Y455 S459 Y513 S572 S626 T634 T651 T654 S698 Y756 S843 T845 S906 Y910 S919 T1018 K1197	Variant Select all * A1018 A919 C283 C315 C756 C910 F235 F317 F698 F906 H276 I1018 I843 L429 L459 M634 M651 M654 M845 N1197 N267 N572 N626 P315 P400 P698 R320 T320	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, icgc, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S235	F235	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S236	*	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S267	N267	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
Y276	H276	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
Y276	*	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
Y283	C283	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
S315	C315	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S315	P315	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S317	F317	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S320	T320	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S320	R320	Biomuta	DOID:363 / uterine cancer [ icgc ]
S400	P400	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S429	L429	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y455	*	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
S459	L459	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
Y513	*	Biomuta	DOID:1319 / brain cancer [ cosmic ]
S572	N572	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
S626	N626	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T634	M634	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
T651	M651	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T654	M654	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
S698	F698	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S698	P698	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
Y756	C756	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S843	I843	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T845	M845	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S906	F906	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y910	C910	Biomuta	[ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S919	A919	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, icgc, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
T1018	I1018	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T1018	A1018	Biomuta	DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K1197	N1197	Biomuta	DOID:363 / uterine cancer [ icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P11274 (BCR)

Protein Information

Interactive Sequence View

P11274 (BCR) as Substrate

P11274 (BCR) as PTM Enzyme

PTM sites affected in variants