iPTMnet Report for P11177 (PDHB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11177 / ODPB_HUMAN
Protein Name Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor
Gene Name Name: PDHB
Synonyms:PHE1B;
Organism Homo sapiens (Human)

PRO ID PR:P11177
DAG View
PRO Name pyruvate dehydrogenase E1 component subunit beta, mitochondrial (human)
Definition A pyruvate dehydrogenase E1 component subunit beta, mitochondrial that is encoded in the genome of human.
Short Label hPDHB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11177 (PDHB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 O-Glycosylation GlyGen 32119511, 34725712, 34229054, ...25367160, 29351928
T26 Phosphorylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
R49 Methylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
S282 O-Glycosylation GlyGen 32119511, 34725712, 34229054, ...25367160, 29351928
S282 Phosphorylation PhosphoSitePlus
K336 Acetylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K347 Acetylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K354 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 P5 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K68 N68 Biomuta DOID:263 / kidney cancer [ cosmic ]
K80 N80 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K80 E80 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K80 R80 Biomuta DOID:3571 / liver cancer [ cosmic ]
K336 E336 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K347 T347 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]