iPTMnet Report for P11172 (UMPS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11172 / UMPS_HUMAN
Protein Name Uridine 5'-monophosphate synthase
Gene Name Name: UMPS
ORFNames:OK/SW-cl.21;
Organism Homo sapiens (Human)

PRO ID PR:P11172
DAG View
PRO Name uridine 5'-monophosphate synthase (human)
Definition A uridine 5'-monophosphate synthase that is encoded in the genome of human.
Short Label hUMPS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11172 (UMPS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
Y16 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
Y37 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 23186163
K106 Acetylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
C174 S-Nitrosylation dbSNO 19483679
T175 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
S214 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S217 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
R459 Methylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y37 Phosphorylation HPRD 18083107
S214 Phosphorylation HPRD 18669648, 20068231
S444 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K29 T29 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S34 F34 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S34 P34 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y37 H37 Biomuta [ cosmic ]
K188 I188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S214 P214 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S241 L241 Biomuta DOID:363 / uterine cancer [ icgc ]
K314 T314 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K324 R324 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K332 N332 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S394 T394 Biomuta DOID:3571 / liver cancer [ cosmic ]
R459 H459 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R459 C459 Biomuta DOID:4159 / skin cancer [ cosmic ]