iPTMnet Report for P11171 (EPB41)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11171 / EPB41_HUMAN
Protein Name Protein 4.1
Gene Name Name: EPB41
Synonyms:E41P;
Organism Homo sapiens (Human)

PRO ID PR:P11171
DAG View
PRO Name protein 4.1 (human)
Definition A protein 4.1 that is encoded in the genome of human.
Short Label hEPB41
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11171 (EPB41) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus   UniProt 21406692
S56 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus   UniProt 15525677, 23186163
T62 Phosphorylation PhosphoSitePlus
R77 Methylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus   UniProt 20068231
S85 Phosphorylation PhosphoSitePlus   UniProt 20068231
S92 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S95 Phosphorylation PhosphoSitePlus   UniProt 23186163
S104 Phosphorylation PhosphoSitePlus   UniProt 23186163
S144 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus   UniProt 21406692
S151 Phosphorylation PhosphoSitePlus   UniProt 21406692
S152 Phosphorylation PhosphoSitePlus   UniProt 21406692
T155 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S188 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S191 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T195 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
C224 Methylation IEDB 31844290
K228 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
C320 Methylation IEDB 31844290
K361 Acetylation PhosphoSitePlus
K361 Methylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K372 Methylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y459 Phosphorylation PhosphoSitePlus
K466 Acetylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S491 O-Glycosylation GlyGen   PhosphoSitePlus 35138101, 28657654, 32119511, ...18984734, 2808371
T494 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus   UniProt 23186163
R526 Methylation PhosphoSitePlus
S536 Phosphorylation IEDB 30784271
S540 Phosphorylation PhosphoSitePlus   UniProt 2171679, 23186163
S542 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S551 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S555 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T559 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
T565 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
Y660 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   Signor   UniProt 1647028, 23186163
S664 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus   UniProt 23186163
S684 Phosphorylation PhosphoSitePlus   UniProt 23186163
K689 Ubiquitination PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus   UniProt 2171679, 23186163
T710 Phosphorylation PhosphoSitePlus
S712 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15525677, 23186163, 18220336, ...18669648, 20068231
T716 Phosphorylation PhosphoSitePlus
T736 Phosphorylation PhosphoSitePlus   UniProt 23186163
K747 Ubiquitination PhosphoSitePlus
T760 O-Glycosylation GlyGen 32119511, 18984734, 35138101, ...2808371, 28657654
Y767 Phosphorylation PhosphoSitePlus
T786 Phosphorylation PhosphoSitePlus
S792 O-Glycosylation GlyGen 2808371
T794 Phosphorylation PhosphoSitePlus
T806 Phosphorylation PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
T823 Phosphorylation PhosphoSitePlus
K842 Ubiquitination PhosphoSitePlus
S849 Phosphorylation PhosphoSitePlus
T851 Phosphorylation PhosphoSitePlus
T859 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
T60 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 15525677
Y627 Phosphorylation PhosphoSitePlus
S679 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 15525677
Site PTM Type PTM Enzyme Score Source PMID
S236 Phosphorylation HPRD 20068231
S237 Phosphorylation HPRD 20068231
S312 Phosphorylation P05771 (PRKCB) HPRD 15611095
S331 Phosphorylation HPRD 19651622
S333 Phosphorylation HPRD 19651622, 18669648
S342 Phosphorylation HPRD 19651622, 18669648
S346 Phosphorylation HPRD 18669648
S369 Phosphorylation HPRD 20068231
Y437 Phosphorylation P00533 (EGFR) HPRD 1647028
S451 Phosphorylation HPRD 20068231
S461 Phosphorylation HPRD 19651622
S486 Phosphorylation HPRD 19651622, 20166139, 20068231
T487 Phosphorylation HPRD 17081983, 20068231
S489 Phosphorylation HPRD 19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation PhosphoSitePlus
S236 Phosphorylation HPRD 20068231
S237 Phosphorylation HPRD 20068231
S312 Phosphorylation P05771 (PRKCB) HPRD   PhosphoSitePlus 15611095
S331 Phosphorylation HPRD   PhosphoSitePlus 19651622
S333 Phosphorylation HPRD 19651622, 18669648
S342 Phosphorylation HPRD 19651622, 18669648
S346 Phosphorylation HPRD 18669648
S369 Phosphorylation HPRD 20068231
Y418 Phosphorylation P00533 (EGFR) HPRD   neXtProt   PhosphoSitePlus 1647028
S432 Phosphorylation HPRD 20068231
S442 Phosphorylation HPRD 19651622
S467 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20166139, 20068231
T468 Phosphorylation HPRD 17081983, 20068231
S470 Phosphorylation HPRD 19651622, 18669648, 20068231
T524 Phosphorylation PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K580 Ubiquitination PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 L14 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R77 K77 Biomuta DOID:4159 / skin cancer [ cosmic ]
S84 F84 Biomuta DOID:4159 / skin cancer [ cosmic ]
S85 L85 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S92 Y92 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S95 F95 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S144 Y144 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S191 T191 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S200 F200 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K228 N228 Biomuta DOID:3571 / liver cancer [ cosmic ]
S312 I312 Biomuta DOID:3571 / liver cancer [ cosmic ]
S312 N312 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
C320 R320 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S333 R333 Biomuta DOID:4159 / skin cancer [ cosmic ]
S342 L342 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K366 N366 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S491 F491 Biomuta DOID:4159 / skin cancer [ cosmic ]
K506 T506 Biomuta DOID:363 / uterine cancer [ icgc ]
S521 N521 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S521 I521 Biomuta DOID:3571 / liver cancer [ cosmic ]
S536 N536 Biomuta DOID:4159 / skin cancer [ cosmic ]
S542 R542 Biomuta DOID:4159 / skin cancer [ cosmic ]
S551 L551 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K580 N580 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S792 P792 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T794 S794 Biomuta DOID:1324 / lung cancer [ cosmic ]
T806 I806 Biomuta DOID:4159 / skin cancer [ cosmic ]
T823 I823 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]