iPTMnet Report for P11161 (EGR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11161 / EGR2_HUMAN
Protein Name E3 SUMO-protein ligase EGR2
Gene Name Name: EGR2
Synonyms:KROX20;
Organism Homo sapiens (Human)

PRO ID PR:P11161
DAG View
PRO Name E3 SUMO-protein ligase EGR2 (human)
Definition An early growth response protein 2 that is encoded in the genome of human.
Short Label hEGR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11161 (EGR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S70 O-Glycosylation GlyGen 29351928
S70 Phosphorylation PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S78 O-Glycosylation GlyGen 29351928
S83 O-Glycosylation GlyGen 29351928
T89 O-Glycosylation GlyGen 29351928
S190 O-Glycosylation GlyGen 29351928
T194 O-Glycosylation GlyGen 29351928
S195 O-Glycosylation GlyGen 29351928
S199 O-Glycosylation GlyGen 29351928
R257 Methylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
T267 O-Glycosylation GlyGen 29351928
S289 O-Glycosylation GlyGen 29351928
R293 Methylation PhosphoSitePlus
S299 O-Glycosylation GlyGen 29351928
S382 O-Glycosylation GlyGen 29351928
T387 O-Glycosylation GlyGen 29351928
T391 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 L70 Biomuta DOID:363 / uterine cancer [ icgc ]
T89 I89 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S199 A199 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
R257 W257 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R293 W293 Biomuta DOID:1612 / breast cancer [ cosmic ]
S299 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]