Protein Information

Cytoscape View


UniProt AC / UniProt ID P11142 / HSP7C_HUMAN
Protein Name Heat shock cognate 71 kDa protein
Gene Name Name: HSPA8
Synonyms:HSC70;
Organism Homo sapiens (Human)

PRO ID PR:P11142
DAG View
PRO Name heat shock cognate 71 kDa protein (human)
Definition A heat shock cognate 71 kDa protein that is encoded in the genome of human.
Short Label hHSPA8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11142 (HSPA8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus
K3 Acetylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
Y15 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
N35 N-Glycosylation GlyGen 24190977
T37 Phosphorylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T45 Phosphorylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
R49 Methylation PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Methylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
Y107 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
S153 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32205407, 17525332
T158 Phosphorylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K187 Acetylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
K246 Acetylation PhosphoSitePlus   UniProt 19608861
K246 Methylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
K257 Acetylation PhosphoSitePlus
K257 Sumoylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
T313 Phosphorylation PhosphoSitePlus
K319 Acetylation PhosphoSitePlus   UniProt 19608861
K319 Ubiquitination PhosphoSitePlus
K325 Acetylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K328 Acetylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus   UniProt 23186163
T341 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K357 Acetylation PhosphoSitePlus
K357 Sumoylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K361 Acetylation PhosphoSitePlus
K361 Sumoylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y371 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
T418 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
T427 Phosphorylation PhosphoSitePlus
T430 O-Glycosylation GlyGen 16408927, 30444036, 30397120, ...24126823, 26374642, 26853435, 21740066, 29351928, 23576270, 23271734, 22967762, 32119511, 22121020
Y431 Phosphorylation PhosphoSitePlus
K451 Acetylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
R469 Methylation PhosphoSitePlus   UniProt 24129315
T477 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
K497 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
T502 Phosphorylation PhosphoSitePlus
K507 Acetylation PhosphoSitePlus
K507 Sumoylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
K512 Acetylation PhosphoSitePlus
K512 Sumoylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K524 Acetylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K539 Acetylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus   UniProt 23186163
S544 Phosphorylation PhosphoSitePlus
Y545 Phosphorylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K557 Methylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K561 Acetylation PhosphoSitePlus
K561 Methylation PhosphoSitePlus   UniProt 24129315
K561 Ubiquitination PhosphoSitePlus
K567 Acetylation PhosphoSitePlus
K567 Methylation PhosphoSitePlus
K569 Methylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
C574 S-Nitrosylation dbSNO 20140087, 22178444
K583 Acetylation PhosphoSitePlus
K583 Sumoylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K589 Acetylation PhosphoSitePlus   UniProt 19608861
K589 Ubiquitination PhosphoSitePlus
K597 Acetylation PhosphoSitePlus   UniProt 19608861
K597 Ubiquitination PhosphoSitePlus
K601 Acetylation PhosphoSitePlus   UniProt 19608861
K601 Methylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
C603 S-Nitrosylation dbSNO 19483679, 20140087, 22178444
T608 Phosphorylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
T641 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S153 Phosphorylation HPRD 17525332
S254 Phosphorylation HPRD 20068231
S329 Phosphorylation HPRD 20068231
S362 Phosphorylation HPRD 20068231
S385 Phosphorylation HPRD 20068231
T397 Phosphorylation HPRD 20068231
T462 Phosphorylation HPRD 18452278
T477 Phosphorylation HPRD 15302935, 18452278
S541 Phosphorylation HPRD 19413330
Y611 Phosphorylation HPRD 18691976
S633 Phosphorylation HPRD 20068231
S637 Phosphorylation HPRD 19413330, 18452278
S638 Phosphorylation HPRD 19413330, 18452278
T641 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S153 Phosphorylation HPRD 17525332
S254 Phosphorylation HPRD 20068231
S329 Phosphorylation HPRD 20068231
S362 Phosphorylation HPRD 20068231
S385 Phosphorylation HPRD 20068231
T397 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T38 A38 Biomuta DOID:4362 / cervical cancer [ tcga ]
Y41 H41 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T45 M45 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
R49 W49 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K128 E128 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y134 * Biomuta DOID:3571 / liver cancer [ icgc ]
T140 N140 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K159 E159 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K187 E187 Biomuta DOID:1324 / lung cancer [ tcga ]
T226 N226 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K348 T348 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S362 I362 Biomuta DOID:363 / uterine cancer [ tcga ]
S400 F400 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T418 A418 Biomuta DOID:1319 / brain cancer [ icgc ]
K451 T451 Biomuta DOID:363 / uterine cancer [ tcga ]
K458 R458 Biomuta DOID:1909 / melanoma [ cosmic ]
T462 A462 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K500 * Biomuta DOID:1324 / lung cancer [ tcga ]
K539 R539 Biomuta DOID:1324 / lung cancer [ cosmic ]
K539 M539 Biomuta DOID:1324 / lung cancer [ tcga ]
S544 P544 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K557 T557 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K597 I597 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
T608 I608 Biomuta DOID:363 / uterine cancer [ tcga ]
T641 S641 Biomuta DOID:10534 / stomach cancer [ tcga ]