iPTMnet Report for P11137 (MAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11137 / MTAP2_HUMAN
Protein Name Microtubule-associated protein 2
Gene Name Name: MAP2
Organism Homo sapiens (Human)

PRO ID PR:P11137
DAG View
PRO Name microtubule-associated protein 2 (human)
Definition A microtubule-associated protein 2 that is encoded in the genome of human.
Short Label hMAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11137 (MAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S63 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
T66 Phosphorylation PhosphoSitePlus
Y67 Phosphorylation P07948 (LYN) , P06241 (FYN) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15536091
S136 Phosphorylation PhosphoSitePlus   RLIMS-P 7525290
T168 Phosphorylation PhosphoSitePlus
S199 O-Glycosylation GlyGen 29485866, 28657654
T216 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
T241 O-Glycosylation GlyGen 29485866, 28657654
T241 Phosphorylation PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
T335 O-Glycosylation GlyGen 29485866, 28657654
S357 Phosphorylation PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus
S385 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
T427 Phosphorylation PhosphoSitePlus
S502 O-Glycosylation GlyGen 29485866, 28657654
T516 Phosphorylation PhosphoSitePlus
T522 O-Glycosylation GlyGen 29485866, 28657654
S532 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
S821 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
S833 Phosphorylation phospho.ELM   PhosphoSitePlus 15822905
S843 Phosphorylation PhosphoSitePlus
T851 O-Glycosylation GlyGen 29485866, 28657654
T860 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus
Y996 Phosphorylation PhosphoSitePlus
S1005 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
S1031 Phosphorylation PhosphoSitePlus
S1082 O-Glycosylation GlyGen 29485866, 28657654
S1106 Phosphorylation PhosphoSitePlus
T1108 Phosphorylation PhosphoSitePlus
S1139 Phosphorylation PhosphoSitePlus
T1154 Phosphorylation PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
S1158 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
S1324 Phosphorylation PhosphoSitePlus
S1347 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1353 Phosphorylation PhosphoSitePlus   UniProt 21406692
T1366 Phosphorylation PhosphoSitePlus
T1368 Phosphorylation PhosphoSitePlus
Y1369 Phosphorylation PhosphoSitePlus
S1398 Phosphorylation PhosphoSitePlus
S1420 Phosphorylation PhosphoSitePlus
S1421 Phosphorylation PhosphoSitePlus
K1427 Acetylation PhosphoSitePlus
S1439 Phosphorylation PhosphoSitePlus
T1440 Phosphorylation PhosphoSitePlus
K1447 Ubiquitination PhosphoSitePlus
K1448 Ubiquitination PhosphoSitePlus
S1480 Phosphorylation PhosphoSitePlus
Y1493 Phosphorylation PhosphoSitePlus
T1494 Phosphorylation PhosphoSitePlus
T1497 Phosphorylation PhosphoSitePlus
S1500 Phosphorylation PhosphoSitePlus
K1505 Acetylation PhosphoSitePlus
T1506 Phosphorylation PhosphoSitePlus
K1524 Acetylation PhosphoSitePlus
S1534 Phosphorylation PhosphoSitePlus
S1539 Phosphorylation PhosphoSitePlus
S1540 Phosphorylation PhosphoSitePlus
S1545 Phosphorylation PhosphoSitePlus
S1546 Phosphorylation PhosphoSitePlus
R1552 Methylation PhosphoSitePlus
S1555 Phosphorylation PhosphoSitePlus
S1562 Phosphorylation PhosphoSitePlus
S1564 Phosphorylation PhosphoSitePlus
S1588 Phosphorylation PhosphoSitePlus
T1590 Phosphorylation PhosphoSitePlus
S1591 Phosphorylation PhosphoSitePlus
T1592 Phosphorylation PhosphoSitePlus
T1594 Phosphorylation PhosphoSitePlus
T1595 Phosphorylation PhosphoSitePlus
S1598 Phosphorylation PhosphoSitePlus
T1599 Phosphorylation PhosphoSitePlus
T1602 Phosphorylation PhosphoSitePlus
T1605 Phosphorylation PhosphoSitePlus
S1608 Phosphorylation PhosphoSitePlus
Y1609 Phosphorylation PhosphoSitePlus
S1611 Phosphorylation PhosphoSitePlus
T1613 Phosphorylation PhosphoSitePlus
T1616 Phosphorylation PhosphoSitePlus
T1619 Phosphorylation PhosphoSitePlus
S1621 Phosphorylation PhosphoSitePlus
Y1622 Phosphorylation PhosphoSitePlus
T1628 Phosphorylation PhosphoSitePlus
T1631 Phosphorylation PhosphoSitePlus
S1634 Phosphorylation PhosphoSitePlus
S1640 Phosphorylation PhosphoSitePlus
T1649 Phosphorylation PhosphoSitePlus
S1653 Phosphorylation PhosphoSitePlus
T1656 Phosphorylation PhosphoSitePlus
S1675 Phosphorylation PhosphoSitePlus
S1679 Phosphorylation P17612 (PRKACA) , Q9P0L2 (MARK1) neXtProt   PhosphoSitePlus   Signor 11029056, 8631898
T1680 Phosphorylation PhosphoSitePlus
K1688 Methylation PhosphoSitePlus
S1702 Phosphorylation PhosphoSitePlus
S1706 Phosphorylation PhosphoSitePlus
S1710 Phosphorylation Q9P0L2 (MARK1) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   Signor 11029056, 8631898
K1724 Methylation PhosphoSitePlus
S1727 Phosphorylation PhosphoSitePlus
S1742 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 11029056
T1780 Phosphorylation PhosphoSitePlus
S1782 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11029056, 24275569, 18220336
S1786 Phosphorylation PhosphoSitePlus
S1787 Phosphorylation PhosphoSitePlus
S1790 Phosphorylation PhosphoSitePlus
S1795 Phosphorylation PhosphoSitePlus
S1798 Phosphorylation PhosphoSitePlus
S1799 Phosphorylation PhosphoSitePlus
S1800 Phosphorylation PhosphoSitePlus
S1802 Phosphorylation PhosphoSitePlus
S1808 Phosphorylation PhosphoSitePlus
T1813 Phosphorylation PhosphoSitePlus
T1819 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S63 Phosphorylation HPRD 17525332
S610 Phosphorylation HPRD 15345747
S654 Phosphorylation HPRD 15345747
S729 Phosphorylation HPRD 15345747
S821 Phosphorylation HPRD 15345747
T1154 Phosphorylation HPRD 19415658
S1155 Phosphorylation HPRD 18510355
S1234 Phosphorylation HPRD 18510355
S1347 Phosphorylation HPRD 18510355, 15345747
S1353 Phosphorylation HPRD 18510355
S1540 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
T1594 Phosphorylation HPRD 15345747
T1602 Phosphorylation HPRD 15345747
T1605 Phosphorylation HPRD 15345747
S1608 Phosphorylation HPRD 15345747
T1619 Phosphorylation HPRD 20058876, 18212344
S1675 Phosphorylation P17612 (PRKACA) HPRD 11029056
S1679 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
S1710 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
T1780 Phosphorylation HPRD 19415658
S1782 Phosphorylation HPRD 20166139, 18707149, 19415658, ...18212344
S1795 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
S1798 Phosphorylation HPRD 17081983
S1799 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
S1800 Phosphorylation HPRD 17081983
S1802 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
Site PTM Type PTM Enzyme Score Source PMID
S63 Phosphorylation HPRD 17525332
Y67 Phosphorylation P06241 (FYN) neXtProt   PhosphoSitePlus 15536091
S184 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
T236 Phosphorylation PhosphoSitePlus
T238 Phosphorylation HPRD 15345747
T246 Phosphorylation HPRD 15345747
T249 Phosphorylation HPRD 15345747
S252 Phosphorylation HPRD 15345747
T263 Phosphorylation HPRD 20058876, 18212344
S319 Phosphorylation P17612 (PRKACA) HPRD 11029056
S323 Phosphorylation Q9P0L2 (MARK1) HPRD   neXtProt 11029056, 8631898
S354 Phosphorylation Q9P0L2 (MARK1) HPRD   neXtProt 11029056, 8631898
T424 Phosphorylation HPRD 19415658
S426 Phosphorylation HPRD   neXtProt 20166139, 11029056, 18707149, ...19415658, 18212344
S439 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
S442 Phosphorylation HPRD 17081983
S443 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
S444 Phosphorylation HPRD 17081983
S446 Phosphorylation Q9P0L2 (MARK1) HPRD 8631898
Site PTM Type PTM Enzyme Score Source PMID
Y50 Phosphorylation P06241 (FYN) PhosphoSitePlus 16145685
Y67 Phosphorylation P06241 (FYN) PhosphoSitePlus 16145685
T286 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
K1423 Acetylation PhosphoSitePlus
T1588 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S63 Phosphorylation HPRD 17525332
S188 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
T320 Phosphorylation HPRD 20058876, 18212344
S411 Phosphorylation PhosphoSitePlus
K412 Methylation PhosphoSitePlus
K416 Methylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
T512 Phosphorylation HPRD 19415658
S514 Phosphorylation HPRD 20166139, 18707149, 19415658, ...18212344
S527 Phosphorylation HPRD 17081983
S530 Phosphorylation HPRD 17081983
S531 Phosphorylation HPRD 17081983
S532 Phosphorylation HPRD 17081983
S534 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y50 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S136 C136 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S188 F188 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S188 P188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S199 P199 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S199 Y199 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S205 F205 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T216 M216 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T246 S246 Biomuta DOID:1324 / lung cancer [ icgc ]
T249 N249 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S285 Y285 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T323 I323 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S354 P354 Biomuta DOID:1612 / breast cancer [ cosmic ]
S357 N357 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K412 N412 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K412 M412 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S418 L418 Biomuta DOID:363 / uterine cancer [ icgc ]
S439 R439 Biomuta DOID:4159 / skin cancer [ cosmic ]
S442 Y442 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S443 L443 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S444 F444 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S446 N446 Biomuta DOID:3571 / liver cancer [ cosmic ]
S502 R502 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S502 G502 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S527 R527 Biomuta DOID:4159 / skin cancer [ cosmic ]
S530 Y530 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S531 L531 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S532 F532 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S534 N534 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y593 C593 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y593 H593 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S654 Y654 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S729 F729 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S785 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S819 N819 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S823 N823 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S833 L833 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S833 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S843 N843 Biomuta DOID:4159 / skin cancer [ cosmic ]
T860 M860 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S862 G862 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S913 L913 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1158 L1158 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1234 N1234 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1347 F1347 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1353 T1353 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1369 C1369 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1398 N1398 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1420 L1420 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T1494 S1494 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1539 T1539 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1545 F1545 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1546 C1546 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1546 F1546 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R1552 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1562 T1562 Biomuta [ cosmic ]
S1564 C1564 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1591 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1598 Y1598 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1602 S1602 Biomuta DOID:1324 / lung cancer [ icgc ]
T1605 N1605 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1611 L1611 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1706 A1706 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1710 P1710 Biomuta DOID:1612 / breast cancer [ cosmic ]
K1724 E1724 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1786 Y1786 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1786 C1786 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1795 R1795 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1798 Y1798 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1799 L1799 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S1800 F1800 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1802 N1802 Biomuta DOID:3571 / liver cancer [ cosmic ]