iPTMnet Report for P11047 (LAMC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11047 / LAMC1_HUMAN
Protein Name Laminin subunit gamma-1 precursor
Gene Name Name: LAMC1
Synonyms:LAMB2;
Organism Homo sapiens (Human)

PRO ID PR:P11047
DAG View
PRO Name laminin subunit gamma-1 (human)
Definition A laminin subunit gamma-1 that is encoded in the genome of human.
Short Label hLAMC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11047 (LAMC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
C69 Methylation IEDB 31844290
S159 Phosphorylation HPRD   PhosphoSitePlus 20068231
K164 Ubiquitination PhosphoSitePlus
T166 Phosphorylation HPRD   PhosphoSitePlus 20068231
S179 Phosphorylation HPRD 20068231
S181 Phosphorylation HPRD   PhosphoSitePlus 20068231
T185 Phosphorylation HPRD 20068231
S187 Phosphorylation HPRD 20068231
K188 Ubiquitination PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus 21851590
T258 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K268 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
C305 Methylation IEDB 31844290
K308 Ubiquitination PhosphoSitePlus
Y413 Phosphorylation PhosphoSitePlus
C504 Methylation IEDB 31844290
N576 N-Glycosylation GlyGen 23090970, 29741879, 29391424, ...24190977
N650 N-Glycosylation GlyGen   UniProt 34089345, 19159218, 24190977, ...23090970, 29391424, 29741879, 12754519
S664 Phosphorylation HPRD 20068231
Y667 Phosphorylation HPRD 20068231
S675 Phosphorylation HPRD 20068231
K788 Ubiquitination PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
N1022 N-Glycosylation GlyGen 23090970, 29741879, 24190977
K1093 Ubiquitination PhosphoSitePlus
R1102 Methylation PhosphoSitePlus
N1107 N-Glycosylation GlyGen   UniProt 16335952, 34089345, 19159218, ...24190977, 23090970, 29391424, 29741879, 29671580
T1109 O-Glycosylation GlyGen 34019948, 34725712, 28657654, ...35289036
T1127 Phosphorylation PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus   UniProt 26091039
N1161 N-Glycosylation GlyGen   UniProt 16335952
T1170 O-Glycosylation GlyGen 30459171
N1175 N-Glycosylation GlyGen   UniProt 16335952, 29671580
T1203 O-Glycosylation GlyGen 34019948, 34725712, 28657654, ...35289036
N1205 N-Glycosylation GlyGen 23090970, 29741879, 24190977, ...29391424, 34089345
S1208 O-Glycosylation GlyGen 34019948, 34725712, 28657654, ...35289036
T1218 O-Glycosylation GlyGen 34846842
N1223 N-Glycosylation GlyGen   UniProt 16335952, 34089345, 24190977, ...23090970, 29391424, 29741879
T1225 O-Glycosylation GlyGen 34019948, 34725712, 28657654, ...35289036
N1241 N-Glycosylation GlyGen   UniProt 34089345, 19159218, 24190977, ...23090970, 29391424, 29741879
S1243 O-Glycosylation GlyGen 34019948, 34725712, 28657654, ...35289036
S1275 Phosphorylation PhosphoSitePlus
K1303 Ubiquitination PhosphoSitePlus
Y1307 Phosphorylation PhosphoSitePlus
K1329 Ubiquitination PhosphoSitePlus
K1371 Ubiquitination PhosphoSitePlus
N1380 N-Glycosylation GlyGen 23090970, 24190977
N1395 N-Glycosylation GlyGen   UniProt 16335952, 34089345, 19159218, ...24190977, 23090970, 29391424, 29741879
K1404 Acetylation PhosphoSitePlus
N1439 N-Glycosylation GlyGen 23090970, 24190977
K1466 Ubiquitination PhosphoSitePlus
S1493 Phosphorylation PhosphoSitePlus   UniProt 21406692
T1529 Phosphorylation PhosphoSitePlus
T1541 Phosphorylation PhosphoSitePlus
K1544 Ubiquitination PhosphoSitePlus
K1557 Ubiquitination PhosphoSitePlus
S1559 Phosphorylation PhosphoSitePlus
K1566 Ubiquitination PhosphoSitePlus
K1584 Ubiquitination PhosphoSitePlus
T1603 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S1605 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N1107 N-Glycosylation PRO 29671580
N1175 N-Glycosylation PRO 29671580
N1241 N-Glycosylation PRO 29741879


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S179 C179 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S181 Y181 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T216 I216 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T216 P216 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K308 R308 Biomuta DOID:4159 / skin cancer [ cosmic ]
S664 G664 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
N1022 Y1022 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K1093 E1093 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R1102 C1102 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1102 H1102 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N1205 D1205 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N1241 T1241 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1243 L1243 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1275 N1275 Biomuta DOID:363 / uterine cancer [ icgc ]
Y1307 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K1329 N1329 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
N1395 D1395 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1404 N1404 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1466 R1466 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T1541 I1541 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1566 N1566 Biomuta DOID:4159 / skin cancer [ cosmic ]