iPTMnet Report for P10914 (IRF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10914 / IRF1_HUMAN
Protein Name Interferon regulatory factor 1
Gene Name Name: IRF1
Organism Homo sapiens (Human)

PRO ID PR:P10914
DAG View
PRO Name interferon regulatory factor 1 (human)
Definition An interferon regulatory factor 1 that is encoded in the genome of human.
Short Label hIRF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10914 (IRF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K39 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
T62 Phosphorylation HPRD 20068231
Y65 Phosphorylation PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
K78 Acetylation UniProt 22367195
K78 Sumoylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K126 Methylation PhosphoSitePlus
T180 Phosphorylation PhosphoSitePlus   RLIMS-P 30854564
S184 Phosphorylation PhosphoSitePlus
S215 Phosphorylation Q14164 (IKBKE) PhosphoSitePlus   RLIMS-P 32784074, 24396068
S219 Phosphorylation Q14164 (IKBKE) PhosphoSitePlus   RLIMS-P 32784074, 24396068
S221 Phosphorylation Q14164 (IKBKE) PhosphoSitePlus   RLIMS-P 32784074, 24396068
K254 Ubiquitination PhosphoSitePlus
C274 Methylation IEDB 31844290
K275 Sumoylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
K299 Sumoylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y65 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K78 T78 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y109 C109 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S184 L184 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S219 F219 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K299 N299 Biomuta DOID:363 / uterine cancer [ icgc ]