iPTMnet Report for P10912 (GHR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10912 / GHR_HUMAN
Protein Name Growth hormone receptor precursor
Gene Name Name: GHR
Organism Homo sapiens (Human)

PRO ID PR:P10912
DAG View
PRO Name growth hormone receptor (human)
Definition A growth hormone receptor that is encoded in the genome of human.
Short Label hGHR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10912 (GHR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S30 O-Glycosylation GlyGen 30459171
T76 Phosphorylation PhosphoSitePlus
C126 Methylation IEDB 31844290
Y218 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation O60674 (JAK2) phospho.ELM   PRO   RLIMS-P 33774052, 9121492
S341 Phosphorylation PhosphoSitePlus   UniProt 24275569
T357 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
Y487 Phosphorylation O60674 (JAK2) phospho.ELM   PRO   RLIMS-P 33774052, 9121492
Y534 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 8647880, 9121492, 33774052
Y566 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 8647880, 33774052, 9121492
Y595 Phosphorylation PhosphoSitePlus
Y627 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 8647880, 9121492, 33774052
S629 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y332 Phosphorylation HPRD 9121492
Y487 Phosphorylation HPRD 9121492
Y534 Phosphorylation HPRD 9121492
Y566 Phosphorylation HPRD 9121492
Y627 Phosphorylation HPRD 9121492


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047530 (hGHR/SigPep-/Phos:1) pY332,pY487,pY534,pY566,pY627 PRO
PR:000047531 (hGHR/SigPep-/Phos:2) pY332,pY487,pY627 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y226 C226 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S367 L367 Biomuta DOID:4159 / skin cancer [ icgc ]
S629 I629 Biomuta DOID:5041 / esophageal cancer [ cosmic ]