iPTMnet Report for P10827 (THRA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10827 / THA_HUMAN
Protein Name Thyroid hormone receptor alpha
Gene Name Name: THRA
Synonyms:EAR7,ERBA1,NR1A1,THRA1,THRA2;
Organism Homo sapiens (Human)

PRO ID PR:P10827
DAG View
PRO Name thyroid hormone receptor alpha (human)
Definition A thyroid hormone receptor alpha that is encoded in the genome of human.
Short Label hTHRA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10827 (THRA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K283 Sumoylation PhosphoSitePlus
K288 Sumoylation PhosphoSitePlus
K389 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S21 T21 Biomuta DOID:4159 / skin cancer [ cosmic ]
K288 E288 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K304 * Biomuta DOID:3571 / liver cancer [ cosmic ]