Protein Information

Cytoscape View


UniProt AC / UniProt ID P10768 / ESTD_HUMAN
Protein Name S-formylglutathione hydrolase
Gene Name Name: ESD
Organism Homo sapiens (Human)

PRO ID PR:P10768
DAG View
PRO Name S-formylglutathione hydrolase (human)
Definition An S-formylglutathione hydrolase that is encoded in the genome of human.
Short Label hESD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10768 (ESD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K10 Acetylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
C11 S-Nitrosylation dbSNO 24105792
K17 Ubiquitination PhosphoSitePlus
C28 S-Nitrosylation dbSNO 26338901
K29 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
C176 S-Nitrosylation dbSNO 19483679
C181 S-Nitrosylation dbSNO 19483679
K185 Acetylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K200 Acetylation PhosphoSitePlus   UniProt 19608861
K200 Ubiquitination PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
K278 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K17 N17 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K17 R17 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
C181 F181 Biomuta DOID:1324 / lung cancer [ cosmic ]
K198 R198 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S214 A214 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y262 H262 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]