iPTMnet Report for P10646 (TFPI)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10646 / TFPI1_HUMAN
Protein Name Tissue factor pathway inhibitor precursor
Gene Name Name: TFPI
Synonyms:LACI,TFPI1;
Organism Homo sapiens (Human)

PRO ID PR:P10646
DAG View
PRO Name tissue factor pathway inhibitor (human)
Definition A tissue factor pathway inhibitor that is encoded in the genome of human.
Short Label hTFPI
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10646 (TFPI) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation P68400 (CSNK2A1) IEDB   phospho.ELM   PhosphoSitePlus 31364055, 2122883
T42 O-Glycosylation GlyGen   UniProt 30459171, 19017259
S52 Phosphorylation PhosphoSitePlus
T115 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T116 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K121 Ubiquitination PhosphoSitePlus
N145 N-Glycosylation GlyGen   UniProt 16335952, 19017259, 23090970, ...24190977, 1388166, 8639592
N195 N-Glycosylation GlyGen   UniProt 1388166, 8639592, 19017259
S202 O-Glycosylation GlyGen   UniProt 1388166, 8639592, 19017259
S202 Phosphorylation P28482 (MAPK1) neXtProt 22028470
T203 O-Glycosylation GlyGen   UniProt 30459171, 1388166, 19017259, ...8639592
T219 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K268 Acetylation PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
K269 Sumoylation PhosphoSitePlus
K293 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N145 N-Glycosylation PRO 8639592, 1388166
N195 N-Glycosylation PRO 8639592, 1388166


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 A30 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T42 M42 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N145 K145 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T219 I219 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T219 N219 Biomuta DOID:3571 / liver cancer [ cosmic ]