iPTMnet Report for P10645 (CHGA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10645 / CMGA_HUMAN
Protein Name Chromogranin-A precursor
Gene Name Name: CHGA
Organism Homo sapiens (Human)

PRO ID PR:P10645
DAG View
PRO Name chromogranin-A (human)
Definition A chromogranin-A that is encoded in the genome of human.
Short Label hCHGA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10645 (CHGA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S48 O-Glycosylation GlyGen 30459171
S53 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S136 Phosphorylation HPRD   PhosphoSitePlus 16807684
S142 Phosphorylation HPRD   PhosphoSitePlus 16807684
T146 Phosphorylation PhosphoSitePlus
T181 O-Glycosylation GlyGen 9852066
T183 O-Glycosylation GlyGen 9852066, 30459171
S191 O-Glycosylation GlyGen 30459171
Y194 Phosphorylation HPRD 9115255, 8910482
S203 Phosphorylation HPRD   PhosphoSitePlus   UniProt 16807684
S218 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 9852066, 14997482
T251 O-Glycosylation GlyGen 9852066, 30459171
S270 Phosphorylation HPRD   PhosphoSitePlus   UniProt 9852066
S272 Phosphorylation PhosphoSitePlus
S300 Phosphorylation HPRD   PhosphoSitePlus   UniProt 16807684
S322 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16807684, 14997482, 24275569
S333 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 9852066, 9115255, 14997482
S375 Phosphorylation PhosphoSitePlus
Y381 Phosphorylation PhosphoSitePlus
S398 Phosphorylation HPRD   PhosphoSitePlus 9115255
S402 Phosphorylation HPRD   PhosphoSitePlus   UniProt 16807684, 9115255
S424 O-Glycosylation GlyGen   UniProt 25326458
S436 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 R53 Biomuta DOID:4159 / skin cancer [ cosmic ]
S113 N113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T146 A146 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S203 N203 Biomuta DOID:1324 / lung cancer [ cosmic ]
S203 T203 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S398 F398 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S398 Y398 Biomuta DOID:1324 / lung cancer [ cosmic ]