iPTMnet Report for P10644 (PRKAR1A)
Protein Information
UniProt AC / UniProt ID | P10644 / KAP0_HUMAN |
Protein Name | cAMP-dependent protein kinase type I-alpha regulatory subunit |
Gene Name | Name: PRKAR1A Synonyms:PKR1,PRKAR1,TSE1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P10644 |
PRO Name | cAMP-dependent protein kinase type I-alpha regulatory subunit (human) |
Definition | A cAMP-dependent protein kinase type I-alpha regulatory subunit that is encoded in the genome of human. |
Short Label | hPRKAR1A |
Category | organism-gene |
P10644 (PRKAR1A) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 19413330, 22814378, 12665801, ... | ||
S5 | Phosphorylation | score1 | PhosphoSitePlus | |||
S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
K24 | Ubiquitination | score1 | PhosphoSitePlus | |||
K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
K70 | Ubiquitination | score1 | PhosphoSitePlus | |||
T73 | Phosphorylation | score1 | PhosphoSitePlus | |||
T75 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S77 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S83 | Phosphorylation | Q00536 (CDK16) , P24941 (CDK2) | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 18691976, 21406692, 17287340, ... | |
K92 | Ubiquitination | score1 | PhosphoSitePlus | |||
S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y122 | Phosphorylation | score1 | PhosphoSitePlus | |||
K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
T124 | O-Glycosylation | score1 | GlyGen | 30379171, 34019948, 34229054 | ||
K130 | Acetylation | score1 | PhosphoSitePlus | |||
K130 | Ubiquitination | score1 | PhosphoSitePlus | |||
K134 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y207 | Phosphorylation | score1 | PhosphoSitePlus | |||
T209 | Phosphorylation | score1 | PhosphoSitePlus | |||
K222 | Ubiquitination | score1 | PhosphoSitePlus | |||
S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
T239 | Phosphorylation | score1 | PhosphoSitePlus | |||
K244 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y246 | Phosphorylation | score1 | PhosphoSitePlus | |||
S251 | Phosphorylation | score1 | PhosphoSitePlus | |||
K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
K261 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y323 | Phosphorylation | score1 | PhosphoSitePlus | |||
T338 | Phosphorylation | score1 | PhosphoSitePlus | |||
R342 | Methylation | score1 | PhosphoSitePlus | |||
K346 | Ubiquitination | score1 | PhosphoSitePlus | |||
C347 | Methylation | score1 | IEDB | 31844290 | ||
K349 | Ubiquitination | score1 | PhosphoSitePlus | |||
K367 | Acetylation | score1 | PhosphoSitePlus | |||
K367 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y373 | Phosphorylation | score1 | PhosphoSitePlus | |||
S375 | Phosphorylation | score1 | PhosphoSitePlus | |||
S380 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T73 | Phosphorylation | score0 | HPRD | 17081983 | ||
T75 | Phosphorylation | score0 | HPRD | 20166139, 17081983 | ||
S77 | Phosphorylation | score0 | HPRD | 18767875, 20058876 | ||
S83 | Phosphorylation | P24941 (CDK2) | score2 | HPRD | 19413330, 18691976, 17287340, ... | |
S101 | Phosphorylation | score2 | HPRD | 6287816, 15345747 | ||
T209 | Phosphorylation | P24941 (CDK2) | score1 | HPRD | 16582606 | |
T239 | Phosphorylation | score0 | HPRD | 18212344 |
P10644 (PRKAR1A) as PTM Enzyme
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S14 | I14 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K24 | Q24 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S77 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
S77 | L77 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S83 | P83 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
S101 | T101 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
K134 | N134 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y207 | N207 | Biomuta | [ cosmic ] | |
K222 | E222 | Biomuta | DOID:3953 / adrenal gland cancer [ cosmic ] | |
S238 | N238 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S238 | T238 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K252 | Q252 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
Y323 | N323 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
R342 | C342 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K346 | T346 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] |