Protein Information

Cytoscape View


UniProt AC / UniProt ID P10599 / THIO_HUMAN
Protein Name Thioredoxin
Gene Name Name: TXN
Synonyms:TRDX,TRX,TRX1;
Organism Homo sapiens (Human)

PRO ID PR:P10599
DAG View
PRO Name thioredoxin (human)
Definition A thioredoxin that is encoded in the genome of human.
Short Label hTXN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10599 (TXN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus   UniProt 19608861
K3 Ubiquitination PhosphoSitePlus
K8 Acetylation PhosphoSitePlus
K8 Methylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
K39 Acetylation PhosphoSitePlus   UniProt 19608861
K39 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
K48 Methylation PhosphoSitePlus
C62 S-Nitrosylation dbSNO 22178444, 17260951
S67 Phosphorylation PhosphoSitePlus
C69 S-Nitrosylation dbSNO 16220319, 18497292, 15688001, ...17260951, 22178444, 18544525
C73 S-Nitrosylation dbSNO 18635375, 19483679, 26338901, ...16408020, 17606900, 18497292, 17260951, 25040305, 22178444, 18544525
T76 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
T100 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P 20619274, 16097034


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T30 M30 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K94 E94 Biomuta DOID:2531 / hematologic cancer [ tcga ]