iPTMnet Report for P10515 (DLAT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10515 / ODP2_HUMAN
Protein Name Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor
Gene Name Name: DLAT
Synonyms:DLTA;
Organism Homo sapiens (Human)

PRO ID PR:P10515
DAG View
PRO Name dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (human)
Definition A dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial that is encoded in the genome of human.
Short Label hDLAT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10515 (DLAT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T35 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus   UniProt 23186163
T102 Phosphorylation PhosphoSitePlus
T107 Phosphorylation IEDB 35494241
T154 Phosphorylation HPRD   PhosphoSitePlus 19664995
Y271 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
T312 Phosphorylation HPRD   PhosphoSitePlus 18491316
S358 Phosphorylation PhosphoSitePlus
K362 Acetylation PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K387 Acetylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K462 Acetylation PhosphoSitePlus
K466 Acetylation PhosphoSitePlus   UniProt 19608861
K466 Ubiquitination PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
K473 Acetylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
K552 Acetylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S80 P80 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K363 R363 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K387 N387 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S391 F391 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K466 T466 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]