iPTMnet Report for P10451 (SPP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10451 / OSTP_HUMAN
Protein Name Osteopontin precursor
Gene Name Name: SPP1
Synonyms:BNSP,OPN;ORFNames:PSEC0156;
Organism Homo sapiens (Human)

PRO ID PR:P10451
DAG View
PRO Name osteopontin (human)
Definition An osteopontin that is encoded in the genome of human.
Short Label hSPP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10451 (SPP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation PhosphoSitePlus   UniProt 15869464
S26 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S27 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
T42 O-Glycosylation GlyGen 30459171
S49 O-Glycosylation GlyGen   PhosphoSitePlus 25813380
S49 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S63 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
T66 Phosphorylation PhosphoSitePlus   UniProt 15869464
S76 Phosphorylation PhosphoSitePlus   UniProt 15869464
S78 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus   UniProt 16807684, 15869464
S99 Phosphorylation PhosphoSitePlus   UniProt 15869464
S102 Phosphorylation PhosphoSitePlus   UniProt 15869464
S105 Phosphorylation PhosphoSitePlus   UniProt 15869464
S108 Phosphorylation PhosphoSitePlus   UniProt 15869464
S117 Phosphorylation PhosphoSitePlus   UniProt 15869464
S120 Phosphorylation PhosphoSitePlus   UniProt 15869464
S123 Phosphorylation PhosphoSitePlus   UniProt 15869464
S126 Phosphorylation PhosphoSitePlus   UniProt 15869464
S129 Phosphorylation PhosphoSitePlus   UniProt 15869464
T134 O-Glycosylation GlyGen   UniProt 15869464
T134 Phosphorylation PhosphoSitePlus
T138 O-Glycosylation GlyGen   UniProt 15869464
T138 Phosphorylation PhosphoSitePlus
T143 O-Glycosylation GlyGen   UniProt 30459171, 15869464
T143 Phosphorylation PhosphoSitePlus
T147 O-Glycosylation GlyGen   UniProt 30459171, 25813380, 15869464
T147 Phosphorylation PhosphoSitePlus
T152 O-Glycosylation GlyGen   UniProt 30459171, 25813380, 15869464
T152 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
T185 O-Glycosylation GlyGen 30237853
T185 Phosphorylation PhosphoSitePlus   UniProt 15869464
T190 Phosphorylation PhosphoSitePlus   UniProt 26091039
S191 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S195 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
Y202 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S219 Phosphorylation PhosphoSitePlus   UniProt 21406692, 26091039, 15869464
S224 Phosphorylation PhosphoSitePlus   UniProt 21406692, 26091039, 15869464
Y225 Phosphorylation PhosphoSitePlus   UniProt 26091039
T227 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S234 O-Glycosylation GlyGen   UniProt 25326458
S234 Phosphorylation PhosphoSitePlus   UniProt 21406692, 26091039, 15869464
T237 Phosphorylation PhosphoSitePlus   UniProt 26091039
S239 Phosphorylation PhosphoSitePlus   UniProt 26091039
S243 Phosphorylation UniProt 26091039
S254 Phosphorylation PhosphoSitePlus   UniProt 21406692, 26091039, 15869464
S258 Phosphorylation PhosphoSitePlus   UniProt 26091039
S263 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S267 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S270 Phosphorylation PhosphoSitePlus   UniProt 26091039
S275 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S280 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S291 Phosphorylation PhosphoSitePlus   UniProt 26091039
S303 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S308 O-Glycosylation GlyGen   UniProt 25326458, 36213313
S308 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S310 Phosphorylation PhosphoSitePlus   UniProt 26091039, 15869464
S311 Phosphorylation PhosphoSitePlus   UniProt 26091039
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 18702456, 20187088, 20068231
S63 Phosphorylation HPRD 20187088, 20068231
T185 Phosphorylation HPRD 18702456
S191 Phosphorylation HPRD 18702456
S195 Phosphorylation HPRD 18702456
S215 Phosphorylation HPRD 18702456, 19664995
S219 Phosphorylation HPRD 18702456, 19664994, 20187088, ...19664995
S224 Phosphorylation HPRD 18702456, 20187088
Y225 Phosphorylation HPRD 20187088
T227 Phosphorylation HPRD 20187088
S228 Phosphorylation HPRD 18702456
S234 Phosphorylation HPRD 18702456, 20187088
T237 Phosphorylation HPRD 20187088
S254 Phosphorylation HPRD 18702456, 20187088
S258 Phosphorylation HPRD 20187088
S263 Phosphorylation HPRD 18702456, 20187088
S267 Phosphorylation HPRD 18702456, 20187088
S270 Phosphorylation HPRD 18702456, 20187088
S275 Phosphorylation HPRD 18702456, 20187088
S280 Phosphorylation HPRD 18702456
S303 Phosphorylation HPRD 19824718, 18702456, 19664994, ...20187088
S308 Phosphorylation HPRD 19824718, 18702456, 20187088, ...19664995
S310 Phosphorylation HPRD 19824718, 20187088, 19415658, ...19664995
S311 Phosphorylation HPRD 18702456, 20187088, 19664995
Site PTM Type PTM Enzyme Score Source PMID
T158 Phosphorylation HPRD 18702456
S164 Phosphorylation HPRD 18702456
S168 Phosphorylation HPRD 18702456
S188 Phosphorylation HPRD 18702456, 19664995
S192 Phosphorylation HPRD 18702456, 19664994, 20187088, ...19664995
S197 Phosphorylation HPRD 18702456, 20187088
Y198 Phosphorylation HPRD 20187088
T200 Phosphorylation HPRD 20187088
S201 Phosphorylation HPRD 18702456
S207 Phosphorylation HPRD 18702456, 20187088
T210 Phosphorylation HPRD 20187088
S227 Phosphorylation HPRD 18702456, 20187088
S231 Phosphorylation HPRD 20187088
S236 Phosphorylation HPRD 18702456, 20187088
S240 Phosphorylation HPRD 18702456, 20187088
S243 Phosphorylation HPRD 18702456, 20187088
S248 Phosphorylation HPRD 18702456, 20187088
S253 Phosphorylation HPRD 18702456
S276 Phosphorylation HPRD 19824718, 18702456, 19664994, ...20187088
S281 Phosphorylation HPRD 19824718, 18702456, 20187088, ...19664995
S283 Phosphorylation HPRD 19824718, 20187088, 19415658, ...19664995
S284 Phosphorylation HPRD 18702456, 20187088, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation HPRD 20068231
T59 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S148 Phosphorylation HPRD 8663267
S148 Phosphorylation P17252 (PRKCA) HPRD 8663267
S148 Phosphorylation P19784 (CSNK2A2) HPRD 8663267
S148 Phosphorylation P68400 (CSNK2A1) HPRD 8663267
S148 Phosphorylation Q13976 (PRKG1) HPRD 8663267
T171 Phosphorylation HPRD 18702456
S177 Phosphorylation HPRD 18702456
S181 Phosphorylation HPRD 18702456
S201 Phosphorylation HPRD 18702456, 19664995
S205 Phosphorylation HPRD 18702456, 19664994, 20187088, ...19664995
S210 Phosphorylation HPRD 18702456, 20187088
Y211 Phosphorylation HPRD 20187088
T213 Phosphorylation HPRD 20187088
S214 Phosphorylation HPRD 18702456
S220 Phosphorylation HPRD 18702456, 20187088
T223 Phosphorylation HPRD 20187088
S240 Phosphorylation HPRD 18702456, 20187088
S244 Phosphorylation HPRD 20187088
S249 Phosphorylation HPRD 18702456, 20187088
S253 Phosphorylation HPRD 18702456, 20187088
S256 Phosphorylation HPRD 18702456, 20187088
S261 Phosphorylation HPRD 18702456, 20187088
S266 Phosphorylation HPRD 18702456
S289 Phosphorylation HPRD 19824718, 18702456, 19664994, ...20187088
S294 Phosphorylation HPRD 19824718, 18702456, 20187088, ...19664995
S296 Phosphorylation HPRD 19824718, 20187088, 19415658, ...19664995
S297 Phosphorylation HPRD 18702456, 20187088, 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 Y24 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T42 S42 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S81 R81 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S108 P108 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S123 A123 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T134 P134 Biomuta DOID:4159 / skin cancer [ cosmic ]
T158 A158 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S168 N168 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S168 I168 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S168 R168 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S168 T168 Biomuta DOID:1324 / lung cancer [ cosmic ]
T171 A171 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S181 T181 Biomuta DOID:1324 / lung cancer [ cosmic ]
S181 I181 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S181 N181 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S181 R181 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T185 A185 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S188 Y188 Biomuta DOID:363 / uterine cancer [ icgc ]
S195 N195 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S195 I195 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S195 T195 Biomuta DOID:1324 / lung cancer [ cosmic ]
S195 R195 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S201 Y201 Biomuta DOID:363 / uterine cancer [ icgc ]
S215 Y215 Biomuta DOID:363 / uterine cancer [ icgc ]
S227 N227 Biomuta DOID:4159 / skin cancer [ cosmic ]
S239 N239 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S239 R239 Biomuta DOID:363 / uterine cancer [ icgc ]
S239 I239 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S240 N240 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
S254 N254 Biomuta DOID:4159 / skin cancer [ cosmic ]
S291 R291 Biomuta DOID:263 / kidney cancer [ cosmic ]