Protein Information

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UniProt AC / UniProt ID P10415 / BCL2_HUMAN
Protein Name Apoptosis regulator Bcl-2
Gene Name Name: BCL2
Organism Homo sapiens (Human)

PRO ID PR:P10415
DAG View
PRO Name apoptosis regulator Bcl-2 (human)
Definition An apoptosis regulator Bcl-2 that is encoded in the genome of human.
Short Label hBCL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10415 (BCL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y9 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S24 Phosphorylation RLIMS-P 16213739
T56 Phosphorylation Q16539 (MAPK14) , P06493 (CDK1) , P53779 (MAPK10) , P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 23638364, 25446991, 19336399, ...12039864, 18201741, 27935869, 18603276, 24166139, 16714293, 25732194, 25354194, 23707954, 15876860, 10359585, 20633548, 24495391, 23272207, 26198300, 21364631, 25922916, 9312139, 25204017, 29050237, 10669763, 10766756
T69 Phosphorylation P45983 (MAPK8) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25090918, 15703383, 25922916, ...28333141, 19029119, 10567572, 21726807, 18570871
S70 Phosphorylation P27361 (MAPK3) , P06493 (CDK1) , P53779 (MAPK10) , Q00534 (CDK6) , P28482 (MAPK1) , P45983 (MAPK8) , P17252 (PRKCA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11323415, 25829774, 10567572, ...25231749, 21993018, 15102520, 25082878, 30273361, 19275204, 11726273, 26430964, 29391599, 26609913, 25300800, 14517609, 29899843, 12086014, 23707954, 17172851, 25791820, 19117992, 16162358, 25922916, 28333141, 22130129, 27483435, 9563469, 18367648, 24594224, 9735392, 25090918, 20005259, 31103719, 26544184, 29435156, 12168105, 29561307, 18845789, 16219908, 24097825, 24166139, 25732194, 24626299, 30840161, 19259124, 16243795, 19545597, 18570871, 27049723, 10675481, 19029119, 11158204, 23638364, 16820582, 18501396, 20633548, 26689988, 27935869, 17342096, 21726807, 10400650, 17610064, 18463240, 27661108, 23277286, 19866475, 23300615, 15291360, 21778226, 11774038, 23566222, 9312139, 16632641, 23558901, 15026553, 20388787, 15210690, 28731137, 18663430, 26252351, 11326318, 10097113, 23193206, 25908963, 25354194, 15800030, 23272207, 23382857, 14572466, 10677502, 11056537, 25181458, 21364631, 18596739, 24677263, 9738012, 10669763
T74 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P53779 (MAPK10) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10359585, 9312139, 23272207, ...12039864, 27935869, 10669763
S87 Phosphorylation Q16539 (MAPK14) , P45983 (MAPK8) , Q00534 (CDK6) , P27361 (MAPK3) , P28482 (MAPK1) , P53779 (MAPK10) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11774038, 19336399, 26689988, ...9735392, 21726807, 15213601, 11326318, 16714293, 15016329, 20157251, 30098987, 23300615, 25354194, 10359585, 19259124, 23272207, 23382857, 18570871, 21747713, 10669763, 15703383, 25922916, 28333141, 9312139, 10675481, 25826088, 27935869, 19029119, 29050237, 11056537, 10567572
C158 S-Nitrosylation dbSNO 22178444, 16980304
C229 S-Nitrosylation dbSNO 22178444, 16980304
Y235 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation P17252 (PRKCA) HPRD 9738012
T56 Phosphorylation HPRD   PRO 10766756, 12039864
T69 Phosphorylation P45983 (MAPK8) HPRD   PRO 15703383, 18570871, 19029119, ...10567572
S70 Phosphorylation P45983 (MAPK8) HPRD   PRO 19029119, 18570871, 15210690, ...10567572, 12039864
T74 Phosphorylation HPRD   PRO 12039864
S87 Phosphorylation P45983 (MAPK8) , P28482 (MAPK1) HPRD   PRO 15225643, 15703383, 12039864, ...19029119, 10567572, 18570871
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation P17252 (PRKCA) HPRD 9738012
T56 Phosphorylation HPRD 12039864
T69 Phosphorylation P45983 (MAPK8) HPRD 10567572
S70 Phosphorylation P45983 (MAPK8) HPRD 10567572, 12039864
T74 Phosphorylation HPRD 12039864
S87 Phosphorylation P45983 (MAPK8) , P28482 (MAPK1) HPRD 15225643, 10567572, 12039864


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027461 (hBCL2/iso:1/Phos:2) pT74 PRO 12039864
PR:000027463 (hBCL2/iso:1/Phos:3) pT69,pS70,pS87 PRO 18570871, 19029119
PR:000027465 (hBCL2/iso:1/Phos:4) pT69,pS87 PRO 15703383
PR:000027467 (hBCL2/iso:1/Phos:5) pT56 PRO 10766756


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S46 P10415 (BCL2) increased_association eFIP 19521340
Phosphorylation P10415 (BCL2) S70 P01106 (MYC) unknown eFIP 15210690
Phosphorylation P10415 (BCL2) T56 P22736 (NR4A1) unknown eFIP 29050237
Phosphorylation P10415 (BCL2) S70 O43521 (BCL2L11) increased_association eFIP 24097825
Phosphorylation P49841 (GSK3B) S9 P10415 (BCL2) decreased_association eFIP 23514933
Phosphorylation Q14457 (BECN1) T119 P10415 (BCL2) decreased_association eFIP 19395874
Phosphorylation Q14457 (BECN1) S295 P10415 (BCL2) unknown eFIP 27245989
Phosphorylation Q99638 (RAD9A) S328 P10415 (BCL2) unknown eFIP 23028682


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027463 (hBCL2/iso:1/Phos:3) NOT Interaction PR:Q14457 (hBECN1) PRO 18570871, 19029119
PR:000027471 (hBECN1/iso:1/Phos:1) decreased Interaction PR:P10415 (hBCL2) PRO 19395874
PR:000036643 (hRAF1/iso:1/Phos:2) Interaction PR:P10415 (hBCL2) PRO 15849194
PR:P10415-1 (hBCL2/iso:Alpha) Interaction PR:P63328 (mPPP3CA) PRO 9109491
PR:P10415-1 (hBCL2/iso:Alpha) Interaction PR:Q07813 (mBAX) PRO 9109491
PR:Q9BXH1-1 (hBBC3/iso:1) Interaction PR:P10415 (hBCL2) PRO 11463392


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y9 * Biomuta DOID:3571 / liver cancer [ icgc ]
K22 R22 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T56 M56 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S87 T87 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S87 R87 Biomuta DOID:2531 / hematologic cancer [ icgc ]