Protein Information

Cytoscape View


UniProt AC / UniProt ID P10412 / H14_HUMAN
Protein Name Histone H1.4
Gene Name Name: H1-4
Synonyms:H1F4;
Organism Homo sapiens (Human)

PRO ID PR:P10412
DAG View
PRO Name histone H1.4 (human)
Definition A histone H1.4 that is encoded in the genome of human.
Short Label hH1-4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10412 (H1-4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 25944712, 20068231
S2 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18491316, 15595731, ...19007248, 20068231
T4 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 15595731, 17081983, ...20058876, 20068231
K17 Acetylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
T18 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   UniProt 19413330, 18691976, 21406692, ...17287340, 17081983, 15595731, 20439994, 18847512, 18234856, 19007248, 19664995, 19651622, 18669648, 24275569, 23186163, 17924679, 20068231, 17043054
T18 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
T18 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K21 Ubiquitination PhosphoSitePlus
K26 Acetylation PRO   PhosphoSitePlus   UniProt 15469825
K26 Methylation PhosphoSitePlus   UniProt 3782055
S27 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   Signor 17287340, 20439994, 16127177, ...15595731, 21511733
S27 Phosphorylation Q96GD4 (AURKB) RLIMS-P+   Signor 21511733
K32 Acetylation PhosphoSitePlus
K32 Methylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K34 Methylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S36 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 21852232, 17287340, 17081983, ...31184227, 19007248, 17043054, 20068231, 20068230
S36 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 21852232
S41 Phosphorylation HPRD   PhosphoSitePlus 19007248, 20068231, 17043054
T45 Phosphorylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
R54 Methylation PhosphoSitePlus
S55 Phosphorylation HPRD   PhosphoSitePlus 20068231
S58 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K64 Methylation PhosphoSitePlus
K64 Sumoylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation HPRD   PhosphoSitePlus 20068231
K75 Acetylation PhosphoSitePlus
K75 Methylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
K97 Methylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
K106 Methylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K119 Methylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K121 Methylation PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
K129 Methylation PhosphoSitePlus
K130 Acetylation PhosphoSitePlus
K136 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
T142 Phosphorylation HPRD 19007248
T146 Phosphorylation HPRD   PRO   PhosphoSitePlus   RLIMS-P   UniProt 15595731, 20439994, 24601643, ...19007248, 20068231
K148 Acetylation PhosphoSitePlus
K148 Methylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
T154 Phosphorylation PRO   PhosphoSitePlus 20439994
K159 Methylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
K171 Methylation PhosphoSitePlus
S172 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus 20439994, 15595731, 17081983, ...20068231
K177 Methylation PhosphoSitePlus
S187 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 15595731, 17081983, ...20439994, 19007248, 19651622, 17043054, 20068231, 28539972
K192 Methylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044872 (hHIST1H1E/InitMet-/Phos:1) pT154 PRO 20439994
PR:000044873 (hHIST1H1E/InitMet-/Phos:2) pT18 PRO 20439994
PR:000044874 (hHIST1H1E/InitMet-/Phos:3) pS187 PRO 20439994
PR:000044875 (hHIST1H1E/InitMet-/Ac:1) acK26 PRO 15469825
PR:000044876 (hHIST1H1E/InitMet-/Phos:4) pT146 PRO 20439994
PR:000044877 (hHIST1H1E/InitMet-/Phos:5) pS172 PRO 20439994
PR:000045400 (hHIST1H1E/InitMet-/Me1Phos:1) pS27 PRO 16127177
PR:000045401 (hHIST1H1E/InitMet-/Phos:7) pS172,pS187 PRO 20439994
PR:000045402 (hHIST1H1E/InitMet-/Phos:8) pT18,pS27,pT146,pT154,pS172,pS187 PRO 20439994


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000044878 (hHIST1H1E/InitMet-/Me1:1) Interaction PR:P45973 (hCBX5) PRO 16127177
PR:000045400 (hHIST1H1E/InitMet-/Me1Phos:1) NOT Interaction PR:P45973 (hCBX5) PRO 16127177
PR:P45973 (hCBX5) Interaction PR:000044878 (hHIST1H1E/InitMet-/Me1:1) PRO 16127177
PR:P45973 (hCBX5) NOT Interaction PR:000045400 (hHIST1H1E/InitMet-/Me1Phos:1) PRO 16127177


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S27 F27 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S27 T27 Biomuta DOID:1324 / lung cancer [ tcga ]
T45 S45 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K46 E46 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S51 F51 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R54 C54 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R54 L54 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S58 P58 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S58 F58 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K63 N63 Biomuta DOID:363 / uterine cancer [ tcga ]
K64 E64 Biomuta DOID:1909 / melanoma [ tcga ]
Y71 C71 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K75 N75 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:5041 / esophageal cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S89 R89 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S89 N89 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T99 A99 Biomuta DOID:363 / uterine cancer [ tcga ]
S102 T102 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
S102 L102 Biomuta DOID:4362 / cervical cancer [ tcga ]
S104 Y104 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S104 C104 Biomuta DOID:2531 / hematologic cancer [ icgc, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S104 F104 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K109 N109 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga, tcga ]
K109 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K110 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K119 Q119 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K121 N121 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K159 E159 Biomuta DOID:1612 / breast cancer [ cosmic ]
K159 N159 Biomuta DOID:10534 / stomach cancer [ tcga ]
K177 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S187 R187 Biomuta DOID:2531 / hematologic cancer [ icgc ]