iPTMnet Report for P10321 (HLA-C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10321 / HLAC_HUMAN
Protein Name HLA class I histocompatibility antigen, C alpha chain precursor
Gene Name Name: HLA-C
Synonyms:HLAC;
Organism Homo sapiens (Human)

PRO ID PR:P10321
DAG View
PRO Name HLA class I histocompatibility antigen, C alpha chain (human)
Definition An MHC class I histocompatibility antigen C alpha chain that is encoded in the genome of human.
Short Label hHLA-C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10321 (HLA-C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation IEDB 27503676
Y31 Phosphorylation PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
R99 Methylation PhosphoSitePlus
N110 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
S112 O-Glycosylation GlyGen 28510447, 30059200
K145 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
R155 Methylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
T214 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S219 Phosphorylation PhosphoSitePlus
T224 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K267 Acetylation PhosphoSitePlus
K267 Methylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
C364 Methylation IEDB 31844290
K365 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R7 Q7 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y83 H83 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K90 M90 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K90 N90 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
R99 Q99 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R99 P99 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R99 L99 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S112 N112 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K145 N145 Biomuta DOID:1612 / breast cancer [ icgc ]
Y147 H147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R155 S155 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T167 S167 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y183 F183 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y195 C195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y195 H195 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
T202 M202 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S275 F275 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]