iPTMnet Report for P10276 (RARA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10276 / RARA_HUMAN
Protein Name Retinoic acid receptor alpha
Gene Name Name: RARA
Synonyms:NR1B1;
Organism Homo sapiens (Human)

PRO ID PR:P10276
DAG View
PRO Name retinoic acid receptor alpha (human)
Definition A retinoic acid receptor alpha that is encoded in the genome of human.
Short Label hRARA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10276 (RARA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S74 Phosphorylation PhosphoSitePlus
S77 Phosphorylation P50613 (CDK7) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 19078967, 15670742, 21297158, ...9230306, 22135230, 33902658, 12054865, 16769902, 16275922, 11955452
S96 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor   UniProt 16417524
K118 Ubiquitination PhosphoSitePlus
S157 Phosphorylation RLIMS-P 10608897
K166 Sumoylation PhosphoSitePlus
K171 Sumoylation PhosphoSitePlus
T181 Phosphorylation P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 15657432
K190 Ubiquitination PhosphoSitePlus
T210 Phosphorylation Q13555 (CAMK2G) neXtProt 17431504
S219 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   UniProt 20215566
S369 Phosphorylation O75582 (RPS6KA5) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 19078967, 16769902, 20215566
K399 Sumoylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S445 Phosphorylation P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 15657432
S461 Phosphorylation P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 15657432
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation PRO 16275922
Site PTM Type PTM Enzyme Score Source PMID
S72 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026078 (hRARA/iso:1/Phos:1) pS77 PRO 16275922


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S96 L96 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S157 P157 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S157 Y157 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K166 T166 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T181 M181 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T210 M210 Biomuta DOID:363 / uterine cancer [ icgc ]
T210 A210 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S219 Y219 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S369 I369 Biomuta DOID:363 / uterine cancer [ icgc ]
S405 F405 Biomuta DOID:4159 / skin cancer [ cosmic ]
S461 C461 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]