iPTMnet Report for P10275 (AR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10275 / ANDR_HUMAN
Protein Name Androgen receptor
Gene Name Name: AR
Synonyms:DHTR,NR3C4;
Organism Homo sapiens (Human)

PRO ID PR:P10275
DAG View
PRO Name androgen receptor (human)
Definition An androgen receptor that is encoded in the genome of human.
Short Label hAR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10275 (AR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation phospho.ELM   PhosphoSitePlus 12015328
R20 Methylation PhosphoSitePlus
S83 Phosphorylation Q00535 (CDK5) , P06493 (CDK1) PhosphoSitePlus   Signor   UniProt 21799006, 20980437, 17043241
S96 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S215 Phosphorylation P31749 (AKT1) , P11309 (PIM1) PhosphoSitePlus   Signor 11156376, 22584579, 17470458, ...14555644, 11404460
T219 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation P16591 (FER) PhosphoSitePlus   Signor   UniProt 23906537, 17045208
S233 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y269 Phosphorylation Q07912 (TNK2) PhosphoSitePlus   UniProt 17494760, 20623637, 17045208, ...20383201
T282 Phosphorylation O14965 (AURKA) PhosphoSitePlus   RLIMS-P 20713353
S293 Phosphorylation O14965 (AURKA) PhosphoSitePlus   RLIMS-P 20713353
S298 Phosphorylation PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus   UniProt 17045208
S310 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) PhosphoSitePlus 25851605, 25691442
Y348 Phosphorylation PhosphoSitePlus   UniProt 17045208
Y359 Phosphorylation PhosphoSitePlus   UniProt 17045208
Y364 Phosphorylation PhosphoSitePlus   UniProt 17045208
Y365 Phosphorylation Q07912 (TNK2) PhosphoSitePlus   UniProt 17494760, 17045208
K388 Sumoylation PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus   UniProt 17045208
R407 Phosphorylation PhosphoSitePlus
S424 Phosphorylation phospho.ELM 12015328
S426 Phosphorylation PhosphoSitePlus
S516 Phosphorylation P50613 (CDK7) , P28482 (MAPK1) , P06493 (CDK1) , P27361 (MAPK3) PhosphoSitePlus   Signor 21157430, 18511414, 23321516
C519 Methylation IEDB 31844290
K521 Sumoylation PhosphoSitePlus
Y535 Phosphorylation P12931 (SRC) PhosphoSitePlus   UniProt 17045208, 20383201
Y552 Phosphorylation PhosphoSitePlus   UniProt 17045208
S579 Phosphorylation Q9NQU5 (PAK6) , P17252 (PRKCA) PhosphoSitePlus 23132866, 18511414
K606 Acetylation PhosphoSitePlus
K610 Acetylation PhosphoSitePlus
K619 Acetylation PhosphoSitePlus
K631 Acetylation PhosphoSitePlus
K631 Methylation PhosphoSitePlus
K633 Acetylation PhosphoSitePlus
K634 Acetylation PhosphoSitePlus
S651 Phosphorylation P45983 (MAPK8) , Q16539 (MAPK14) , P27361 (MAPK3) PhosphoSitePlus   UniProt 21512132, 16282370
R761 Methylation PhosphoSitePlus
S792 Phosphorylation P31749 (AKT1) PhosphoSitePlus 14555644, 11156376, 17470458, ...11404460
S815 Phosphorylation RLIMS-P 36470072
K826 Ubiquitination PhosphoSitePlus
K837 Acetylation PhosphoSitePlus
K846 Ubiquitination PhosphoSitePlus   UniProt 19345326
K848 Ubiquitination PhosphoSitePlus   UniProt 19345326
T851 Phosphorylation P11309 (PIM1) PhosphoSitePlus 22584579
Y858 Phosphorylation PhosphoSitePlus
Y916 Phosphorylation PhosphoSitePlus   UniProt 17045208
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 12015328
S83 Phosphorylation HPRD 12015328
S96 Phosphorylation HPRD 12015328
S208 Phosphorylation P31749 (AKT1) HPRD 11404460
S215 Phosphorylation P31749 (AKT1) HPRD 11156376, 11404460
S258 Phosphorylation HPRD 12015328
S302 Phosphorylation HPRD 12015328
S310 Phosphorylation HPRD 11396978
S424 Phosphorylation HPRD 12015328
S516 Phosphorylation P28482 (MAPK1) HPRD 10318905
K631 Acetylation PR:000007102 (EP300) , PR:000012332 (KAT2B) PRO 11971970
K633 Acetylation PR:000007102 (EP300) , PR:000012332 (KAT2B) PRO 11971970
K634 Acetylation PR:000012332 (KAT2B) , PR:000007102 (EP300) PRO 11971970
S651 Phosphorylation HPRD 12015328
S792 Phosphorylation P31749 (AKT1) HPRD 11404460
Site PTM Type PTM Enzyme Score Source PMID
S119 Phosphorylation HPRD 12015328
S260 Phosphorylation P31749 (AKT1) HPRD 11404460


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028792 (hAR/iso:1/Ac:1) acK631,acK633,acK634 PR:000012332 (KAT2B) PRO 11971970
PR:000028792 (hAR/iso:1/Ac:1) acK631,acK633,acK634 PR:000007102 (EP300) PRO 11971970


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P40763 (STAT3) S727 P10275 (AR) unknown eFIP 30470788
Phosphorylation P40763 (STAT3) S727 P10275 (AR) unknown eFIP 23941877


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S83 R83 Biomuta DOID:4159 / skin cancer [ cosmic ]
S96 Y96 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S96 F96 Biomuta DOID:4159 / skin cancer [ cosmic ]
S215 L215 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S220 F220 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
Y225 D225 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S233 F233 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S244 A244 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S244 L244 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
T282 P282 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T282 S282 Biomuta DOID:184 / bone cancer [ cosmic ]
S293 P293 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S293 A293 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S298 R298 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S310 F310 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y359 D359 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y364 N364 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K388 R388 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y395 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R407 H407 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R407 C407 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y552 H552 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K606 E606 Biomuta DOID:4159 / skin cancer [ cosmic ]
K610 N610 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K631 N631 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K633 N633 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K633 T633 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S792 P792 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S792 F792 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S815 N815 Biomuta DOID:3571 / liver cancer [ cosmic ]
K837 N837 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K848 N848 Biomuta DOID:1324 / lung cancer [ cosmic ]