iPTMnet Report for P10253 (GAA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10253 / LYAG_HUMAN
Protein Name Lysosomal alpha-glucosidase precursor
Gene Name Name: GAA
Organism Homo sapiens (Human)

PRO ID PR:P10253
DAG View
PRO Name lysosomal alpha-glucosidase (human)
Definition A lysosomal alpha-glucosidase that is encoded in the genome of human.
Short Label hGAA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10253 (GAA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T52 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S61 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
N140 N-Glycosylation GlyGen   UniProt 34089345, 8435067, 19159218, ...24190977, 23090970, 29061980, 29741879, 17293352
S142 O-Glycosylation GlyGen 28411811, 32574038, 34725712, ...30620550, 22661428, 35289036, 28657654
S144 O-Glycosylation GlyGen 28411811, 32574038, 34725712, ...30620550, 22661428, 35289036, 28657654
T149 O-Glycosylation GlyGen 28411811, 32574038, 34725712, ...30620550, 22661428, 35289036, 28657654
T153 O-Glycosylation GlyGen 22661428
K162 Ubiquitination PhosphoSitePlus
N233 N-Glycosylation GlyGen   UniProt 29741879, 8435067, 17293352, ...29061980
T235 Phosphorylation PhosphoSitePlus
N390 N-Glycosylation GlyGen   UniProt 16335952, 34089345, 8435067, ...24190977, 23090970, 29061980, 23345538, 29741879, 17293352
Y407 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
N470 N-Glycosylation GlyGen   UniProt 34089345, 8435067, 19159218, ...29061980, 23090970, 24190977, 29741879, 12754519, 17293352
N652 N-Glycosylation GlyGen   UniProt 29741879, 8435067, 17293352, ...29061980
S676 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
Y822 Phosphorylation PhosphoSitePlus
N882 N-Glycosylation GlyGen   UniProt 8435067, 19159218, 29061980, ...23090970, 24190977, 23345538, 29741879, 17293352
N883 N-Glycosylation GlyGen 24190977
T884 O-Glycosylation GlyGen 28411811, 32574038, 34725712, ...30620550, 22661428, 35289036, 28657654
T884 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
N925 N-Glycosylation GlyGen   UniProt 29741879, 8435067, 17293352, ...19159218
Site PTM Type PTM Enzyme Score Source PMID
N140 N-Glycosylation PRO 17293352
N233 N-Glycosylation PRO 17293352
N390 N-Glycosylation PRO 17293352, 23345538
N470 N-Glycosylation PRO 17293352
N652 N-Glycosylation PRO 17293352
N882 N-Glycosylation PRO 23345538


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S142 R142 Biomuta DOID:263 / kidney cancer [ cosmic ]
T149 M149 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T235 M235 Biomuta DOID:263 / kidney cancer [ cosmic ]
S894 I894 Biomuta DOID:3571 / liver cancer [ cosmic ]