Protein Information

Cytoscape View


UniProt AC / UniProt ID P10253 / LYAG_HUMAN
Protein Name Lysosomal alpha-glucosidase precursor
Gene Name Name: GAA
Organism Homo sapiens (Human)

PRO ID PR:P10253
DAG View
PRO Name lysosomal alpha-glucosidase (human)
Definition A lysosomal alpha-glucosidase that is encoded in the genome of human.
Short Label hGAA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10253 (GAA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 O-Glycosylation PhosphoSitePlus
T52 O-Glycosylation PhosphoSitePlus
S61 O-Glycosylation PhosphoSitePlus
N140 N-Glycosylation UniProt 8435067, 19159218, 29061980
K162 Ubiquitination PhosphoSitePlus
N233 N-Glycosylation UniProt 8435067, 29061980
T235 Phosphorylation PhosphoSitePlus
N390 N-Glycosylation UniProt 16335952, 8435067, 29061980
Y407 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
N470 N-Glycosylation UniProt 12754519, 8435067, 19159218, ...29061980
N652 N-Glycosylation UniProt 8435067, 29061980
S676 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
Y822 Phosphorylation PhosphoSitePlus
N882 N-Glycosylation UniProt 8435067, 19159218, 29061980
T884 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
N925 N-Glycosylation UniProt 8435067, 19159218


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S894 I894 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]