Protein Information

Cytoscape View

UniProt AC / UniProt ID P10244 / MYBB_HUMAN
Protein Name Myb-related protein B
Gene Name Name: MYBL2
Organism Homo sapiens (Human)

PRO ID PR:P10244
DAG View
PRO Name Myb-related protein B (human)
Definition A Myb-related protein B that is encoded in the genome of human.
Short Label hMYBL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P10244 (MYBL2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y15 Phosphorylation PhosphoSitePlus
T18 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 11522824
S20 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus   RLIMS-P 30206359
K33 Ubiquitination PhosphoSitePlus
K93 Sumoylation PhosphoSitePlus
K104 Sumoylation PhosphoSitePlus
K134 Sumoylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K197 Sumoylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
K236 Sumoylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332, ...20068231
T266 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10593981, 17081983
S282 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28128338, 10593981, 23186163
T286 Phosphorylation RLIMS-P 28128338
S287 Phosphorylation RLIMS-P 28128338
S362 Phosphorylation PhosphoSitePlus
S393 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 10593981
T396 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus   UniProt 10095772
S443 Phosphorylation PhosphoSitePlus
T444 Phosphorylation P24941 (CDK2) phospho.ELM   Signor   UniProt 9840932, 10095772
K447 Ubiquitination PhosphoSitePlus
S452 Phosphorylation neXtProt   PhosphoSitePlus 10593981
S454 Phosphorylation PhosphoSitePlus
T465 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T476 Phosphorylation PhosphoSitePlus   RLIMS-P 30321399
T486 Phosphorylation PhosphoSitePlus
T487 Phosphorylation P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9840932, 28128338, 30321399, ...10593981, 23449447
T494 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor   UniProt 9840932, 10095772
K499 Ubiquitination PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus   UniProt 23186163
K509 Sumoylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
T515 Phosphorylation neXtProt 10593981
T518 Phosphorylation neXtProt   PhosphoSitePlus 10593981
T520 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor   UniProt 10593981, 10095772
K523 Ubiquitination PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
K533 Acetylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
T538 Phosphorylation PhosphoSitePlus
K546 Sumoylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
S577 Phosphorylation P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9840932, 32979888, 10095772, ...10593981, 23449447
K584 Ubiquitination PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
K596 Sumoylation PhosphoSitePlus
K625 Sumoylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
K639 Sumoylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
T693 Phosphorylation PhosphoSitePlus
R695 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S241 Phosphorylation HPRD 19413330, 20068231, 18452278
T266 Phosphorylation P24941 (CDK2) HPRD 10593981, 20068231
S282 Phosphorylation HPRD 10593981, 18452278
S393 Phosphorylation P24941 (CDK2) HPRD 10593981, 15302935
T405 Phosphorylation P24941 (CDK2) HPRD 10593981
T440 Phosphorylation P24941 (CDK2) HPRD 10095772
T444 Phosphorylation P24941 (CDK2) HPRD 9840932
S452 Phosphorylation P24941 (CDK2) HPRD 10593981
T487 Phosphorylation P24941 (CDK2) HPRD 9840932
T494 Phosphorylation P24941 (CDK2) HPRD 9840932
T515 Phosphorylation P24941 (CDK2) HPRD 10593981
T518 Phosphorylation P24941 (CDK2) HPRD 10593981
T520 Phosphorylation P24941 (CDK2) HPRD 10593981, 10095772
S577 Phosphorylation P24941 (CDK2) HPRD 9840932
S600 Phosphorylation HPRD 20068231

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P10244 (MYBL2) T476 P53350 (PLK1) unknown eFIP 30321399

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K93 Q93 Biomuta DOID:1909 / melanoma [ cosmic ]
K181 T181 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K197 N197 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S282 F282 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S362 F362 Biomuta DOID:1324 / lung cancer [ tcga ]
T405 A405 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T440 M440 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S443 N443 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S452 L452 Biomuta DOID:363 / uterine cancer [ tcga ]
S454 F454 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S472 L472 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T518 M518 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
T520 A520 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T520 N520 Biomuta DOID:263 / kidney cancer [ cosmic ]
S600 F600 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R695 W695 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R695 Q695 Biomuta DOID:1909 / melanoma [ icgc, tcga ]