iPTMnet Report for P10071 (GLI3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10071 / GLI3_HUMAN
Protein Name Transcriptional activator GLI3
Gene Name Name: GLI3
Organism Homo sapiens (Human)

PRO ID PR:P10071
DAG View
PRO Name transcriptional activator GLI3 (human)
Definition A transcriptional activator GLI3 that is encoded in the genome of human.
Short Label hGLI3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10071 (GLI3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
M1 Acetylation UniProt 19413330
S19 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S45 Phosphorylation PhosphoSitePlus
S78 O-Glycosylation GlyGen 28411811, 30620550
S101 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
R175 Methylation PhosphoSitePlus
R220 Methylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S343 Phosphorylation RLIMS-P 20865152
K436 Methylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K595 Methylation PhosphoSitePlus
K640 Acetylation PhosphoSitePlus
K641 Acetylation PhosphoSitePlus
S664 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163
T669 Phosphorylation HPRD   PhosphoSitePlus 19651622
K773 Ubiquitination PhosphoSitePlus   UniProt 16705181
K779 Ubiquitination PhosphoSitePlus   UniProt 16705181
K784 Ubiquitination PhosphoSitePlus   UniProt 16705181
K800 Ubiquitination PhosphoSitePlus   UniProt 16705181
S849 Phosphorylation PRO   PhosphoSitePlus   Signor   UniProt 10693759
S849 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10693759
S850 Phosphorylation PhosphoSitePlus
T853 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PRO   PhosphoSitePlus   Signor   UniProt 10693759
S865 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10693759
S872 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PRO   PhosphoSitePlus   Signor   UniProt 10693759
S877 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10693759
S903 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PRO   PhosphoSitePlus   Signor   UniProt 10693759
S907 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10693759
Y933 Phosphorylation PhosphoSitePlus
S980 Phosphorylation PRO   PhosphoSitePlus   Signor   UniProt 10693759
S980 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10693759
S1006 Phosphorylation PRO   PhosphoSitePlus   Signor   UniProt 10693759
S1006 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10693759
Y1254 Phosphorylation PhosphoSitePlus
S1401 Phosphorylation PhosphoSitePlus
T1412 Phosphorylation PhosphoSitePlus
S1413 Phosphorylation PhosphoSitePlus
T1415 Phosphorylation PhosphoSitePlus
T1539 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047548 (hGLI3/Phos:1) pS849,pS865,pS877,pS907,pS980,pS1006 PRO
PR:000047549 (hGLI3/PhosRes+) p PRO
PR:000047550 (hGLI3/PhosUbiq+) ub PRO
PR:000047550 (hGLI3/PhosUbiq+) p PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q9Z0P7-4 (mSUFU/iso:4) Interaction PR:P10071 (hGLI3) PRO 10531011


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 F19 Biomuta DOID:4159 / skin cancer [ cosmic ]
S78 L78 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y168 F168 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R175 K175 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R220 P220 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R220 C220 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R220 H220 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R220 L220 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S223 N223 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S257 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S295 F295 Biomuta DOID:4159 / skin cancer [ cosmic ]
K436 T436 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K436 N436 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S445 R445 Biomuta DOID:1324 / lung cancer [ cosmic ]
S664 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S664 L664 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T669 S669 Biomuta DOID:263 / kidney cancer [ cosmic ]
K800 T800 Biomuta DOID:3119 / gastrointestinal system cancer [ cosmic ]
S850 I850 Biomuta DOID:1324 / lung cancer [ cosmic ]
T853 S853 Biomuta DOID:1324 / lung cancer [ cosmic ]
S855 N855 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S864 F864 Biomuta DOID:4159 / skin cancer [ cosmic ]
S872 P872 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S873 R873 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S903 L903 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S907 C907 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S907 I907 Biomuta DOID:4606 / bile duct cancer [ cosmic ]