iPTMnet Report P0DP23 CALM1

Protein Information

UniProt AC / UniProt ID	P0DP23 / CALM1_HUMAN
Protein Name	Calmodulin-1
Gene Name	Name: CALM1 Synonyms:CALM,CAM,CAM1;
Organism	Homo sapiens (Human)

PRO ID	PR:P0DP23 DAG View
PRO Name	calmodulin-1 (human)
Definition	A calmodulin (human) that is a translation product of the CALM1 gene.
Short Label	hCALM1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P0DP23 (CALM1) as Substrate

P0DP23

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position A2 K14 S18 K22 T29 T30 K31 T35 R38 K76 K78 T80 S82 R87 R91 K95 Y100 S102 R107 T111 K116 T118 Y139 T147 K149	PTM Type Select all Acetylation Methylation Phosphorylation Ubiquitination	PTM Enzyme Select all P00533 (EGFR) P06213 (INSR)	Score Select all 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P Signor UniProt	PMID
A2	Acetylation		score3	UniProt	19413330, 22814378, 22223895, ...25944712, 7093203
K14	Acetylation		score1	PhosphoSitePlus
K14	Ubiquitination		score1	PhosphoSitePlus
S18	Phosphorylation		score1	PhosphoSitePlus
K22	Acetylation		score2	PhosphoSitePlus UniProt	19608861
K22	Ubiquitination		score1	PhosphoSitePlus
T29	Phosphorylation		score1	PhosphoSitePlus
T30	Phosphorylation		score1	PhosphoSitePlus
K31	Acetylation		score1	PhosphoSitePlus
K31	Ubiquitination		score1	PhosphoSitePlus
T35	Phosphorylation		score1	PhosphoSitePlus
R38	Methylation		score1	PhosphoSitePlus
K76	Acetylation		score1	PhosphoSitePlus
K76	Ubiquitination		score1	PhosphoSitePlus
K78	Acetylation		score1	PhosphoSitePlus
K78	Ubiquitination		score1	PhosphoSitePlus
T80	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	19752189
S82	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
R87	Methylation		score1	PhosphoSitePlus
R91	Methylation		score1	PhosphoSitePlus
K95	Acetylation		score2	PhosphoSitePlus UniProt	19608861
K95	Ubiquitination		score1	PhosphoSitePlus
Y100	Phosphorylation		score4	HPRD PhosphoSitePlus Signor UniProt	17016520, 18578522, 17389395, ...17287340, 18669648, 3415247, 19901323, 18707149, 7925415, 12153558, 19690332, 20068231, 16497976
Y100	Phosphorylation	P00533 (EGFR)	score3	HPRD Signor	17016520, 19901323, 18578522, ...17389395, 17287340, 18669648, 3415247, 18707149, 7925415, 12153558, 20068231, 16497976
Y100	Phosphorylation	P06213 (INSR)	score3	HPRD Signor	17016520, 19901323, 18578522, ...17389395, 17287340, 18669648, 3415247, 18707149, 12153558, 20068231, 16497976
S102	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	21406692, 23186163, 24275569, ...20166139, 20068231
R107	Methylation		score1	PhosphoSitePlus
T111	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
K116	Acetylation		score1	PhosphoSitePlus
K116	Methylation		score2	PhosphoSitePlus UniProt	24129315
T118	Phosphorylation		score1	PhosphoSitePlus
Y139	Phosphorylation		score4	HPRD PhosphoSitePlus UniProt	8639568, 19690332
Y139	Phosphorylation	P06213 (INSR)	score1	HPRD	8639568
T147	Phosphorylation		score1	PhosphoSitePlus
K149	Acetylation		score1	PhosphoSitePlus
K149	Ubiquitination		score1	PhosphoSitePlus

PTM-dependent PPI

Search:

PTM type Select all Phosphorylation	Substrate Select all O00418 (EEF2K) P14151 (SELL) Q92686 (NRGN)	Site Select all By amino acid All Serine By position S36 S78 S364	Interactant Select all P0DP23 (CALM1)	Association type Select all inhibited_association unknown	Source Select all eFIP	PMID
Phosphorylation	O00418 (EEF2K)	S78	P0DP23 (CALM1)	unknown	eFIP	14684180
Phosphorylation	P14151 (SELL)	S364	P0DP23 (CALM1)	unknown	eFIP	25775539
Phosphorylation	Q92686 (NRGN)	S36	P0DP23 (CALM1)	inhibited_association	eFIP	23462742

PTM sites affected in variants

Search:

Site Select all By amino acid All Tyrosine By position K31 R91 Y100 R107	Variant Select all * C107 E31 H100 H107	Source Select all Biomuta	Disease [Sample source] Select all DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] [ cosmic ]
K31	E31	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R91	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y100	H100	Biomuta	[ cosmic ]
R107	C107	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R107	H107	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P0DP23 (CALM1)

Protein Information

Interactive Sequence View

P0DP23 (CALM1) as Substrate

PTM-dependent PPI

PTM sites affected in variants