iPTMnet Report for P0DP23 (CALM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P0DP23 / CALM1_HUMAN
Protein Name Calmodulin-1
Gene Name Name: CALM1
Synonyms:CALM,CAM,CAM1;
Organism Homo sapiens (Human)

PRO ID PR:P0DP23
DAG View
PRO Name calmodulin-1 (human)
Definition A calmodulin (human) that is a translation product of the CALM1 gene.
Short Label hCALM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P0DP23 (CALM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712, 7093203
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K22 Acetylation PhosphoSitePlus   UniProt 19608861
K22 Ubiquitination PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
R38 Methylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus   RLIMS-P 19752189
S82 Phosphorylation PhosphoSitePlus   UniProt 23186163
R87 Methylation PhosphoSitePlus
R91 Methylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus   UniProt 19608861
K95 Ubiquitination PhosphoSitePlus
Y100 Phosphorylation HPRD   PhosphoSitePlus   Signor   UniProt 17016520, 18578522, 17389395, ...17287340, 18669648, 3415247, 19901323, 18707149, 7925415, 12153558, 19690332, 20068231, 16497976
Y100 Phosphorylation P00533 (EGFR) HPRD   Signor 17016520, 19901323, 18578522, ...17389395, 17287340, 18669648, 3415247, 18707149, 7925415, 12153558, 20068231, 16497976
Y100 Phosphorylation P06213 (INSR) HPRD   Signor 17016520, 19901323, 18578522, ...17389395, 17287340, 18669648, 3415247, 18707149, 12153558, 20068231, 16497976
S102 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 24275569, ...20166139, 20068231
R107 Methylation PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus   UniProt 24275569
K116 Acetylation PhosphoSitePlus
K116 Methylation PhosphoSitePlus   UniProt 24129315
T118 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation HPRD   PhosphoSitePlus   UniProt 8639568, 19690332
Y139 Phosphorylation P06213 (INSR) HPRD 8639568
T147 Phosphorylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00418 (EEF2K) S78 P0DP23 (CALM1) unknown eFIP 14684180
Phosphorylation P14151 (SELL) S364 P0DP23 (CALM1) unknown eFIP 25775539
Phosphorylation Q92686 (NRGN) S36 P0DP23 (CALM1) inhibited_association eFIP 23462742


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K31 E31 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R91 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y100 H100 Biomuta [ cosmic ]
R107 C107 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R107 H107 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]